Results 81 to 90 of about 4,105 (107)

Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats.

The Journal of Pharmacology and Experimental Therapeutics, 1996
ATP produces significant cardiovascular effects by activation of P2 purinoceptors. In the present study, we examined the regional hemodynamic profiles produced by intravenous administration of a P2X and a P2Y purinergic receptor agonist. Sprague-Dawley rats were anesthetized with Inactin, catheters were placed in the femoral artery and vein and the ...
B F, Cox, G J, Smits
openaire   +3 more sources

Sensitization of Adenylyl Cyclase by P2 Purinergic and M5 Muscarinic Receptor Agonists in L Cells

Molecular Pharmacology, 1991
Many hormones have been shown to activate phospholipase C, which results in the hydrolysis of membrane polyphosphoinositides, such as phosphatidylinositol 4,5-bisphosphate (PIP2). Two second messengers are known to be produced by PIP2 hydrolysis, 1,2-diacylglycerol, an endogenous activator of a family of enzymes called protein kinase C (PKCs), and ...
J A, Johnson, J, Friedman, R D, Halligan, M, Birnbaumer, R B, Clark   +4 more
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The Synthesis of Cyclonucleotides with Fixed Glycosidic Bond Linkages as Putative Agonists for P2-Purinergic Receptors

Nucleosides, Nucleotides and Nucleic Acids, 2000
Cyclonucleotides with fixed glycosidic bond linkages were investigated as possible ligands for purinoceptors in PC12 cells. P2Y2-purinoceptors were not activated by the ATP analogue, 8,2'-thioanhydroadenosine-5'-triphosphate (4) and only weakly by the UTP analogue, 2,2' -anhydrouridine-5'-triphosphate (6). However, both analogues were agonists for P2X2-
G, Tusa, J K, Reed
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ChemInform Abstract: The Synthesis of Cyclonucleotides with Fixed Glycosidic Bond Linkages as Putative Agonists for P2‐Purinergic Receptors.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Girolamo Tusa, Juta K. Reed
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Chronic Treatment With P2-Purinergic Receptor Agonists Induces Phenotypic Modulation of the HL-60 and U937 Human Myelogenous Leukemia Cell Lines

Journal of Leukocyte Biology, 1991
Abstract In previous studies we have demonstrated that extracellular ATP (and UTP), acting through P2-purinergic receptors, can stimulate the inositol phospholipid signaling system in neutrophils and monocytes, as well as in neutrophil monocyte progenitor cells.
D S, Cowen, M, Berger, L, Nuttle, G R, Dubyak   +3 more
openaire   +3 more sources

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Unveiling the agonistic properties of Preyssler-type Polyoxotungstates on purinergic P2 receptors

Journal of Inorganic Biochemistry
The Preyssler-type polyoxotungstate ({P5W30}) belongs to the family of polyanionic metal-oxides formed by group V and VI metal ions, such as V, Mo and W, commonly known as polyoxometalates (POMs). POMs have demonstrated inhibitory effect on a significant number of ATP-binding proteins in vitro.
Poejo, Joana, Gumerova, Nadiia I., Rompel, Annette, Mata, Ana M., Aureliano, Manuel, Gutierrez-Merino, Carlos   +5 more
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Victoria Metaxa   +2 more
exaly