Results 81 to 90 of about 13,838 (206)
P2X7 expression patterns in the developing Fmr1‐knockout mouse hippocampus
Hippocampus, Volume 34, Issue 11, Page 633-644, November 2024.Abstract Fragile‐X Syndrome (FXS) is the leading monogenetic cause of intellectual disability among children but remains without a cure. Using the Fmr1 KO mouse model of FXS, much work has been done to understand FXS hippocampus dysfunction. Purinergic signaling, where ATP and its metabolites are used as signaling molecules, participates in hippocampus
Matthew Napier +4 more
wiley +1 more source
ATP Hysteresis in Tripartite Synapses [PDF]
arXiv, 2009 Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial adenosine with the neuron suggest the existence
arxiv
Molecular regulation of calcium‐sensing receptor (CaSR)‐mediated signaling
Chronic Diseases and Translational Medicine, Volume 10, Issue 3, Page 167-194, September 2024.The CaSR interactome characterizes the life cycle of CaSR and its signaling capacity. (1) Extracellular calcium activates CaSR and (2) mediates intracellular G‐protein‐coupled signaling, leading to ER calcium release by generating IP3 through phospholipase C (PLC) hydrolysis of PIP2.
Li Tian +3 more
wiley +1 more source
Modeling Suggests Combined-Drug Treatments for Disorders Impairing Synaptic Plasticity via Shared Signaling Pathways [PDF]
arXiv, 2020 Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharmacological therapies be suggested to improve learning and memory in these disorders?
arxiv
Journal of Neurochemistry, Volume 168, Issue 9, Page 3050-3062, September 2024.Lysophosphatidic acid (LPA) is a phospholipid with critical roles in the developing and adult brain. Besides typical LPA receptors, proteins such as the phospholipid phosphatase‐related PLPPRs may serve as atypical regulators of LPA functions. Here, we have investigated PLPPR expression and localization in several brain regions as well as their neuron ...
Alexandra Polyzou +8 more
wiley +1 more source
Functional characterization of P2Y1 and P2X4 receptors in human neuroblastoma SK-N-MC cells [PDF]
, 2015 Nucleotides are important signalling molecules in both the peripheral and central nervous system. However, the in vitro study of their receptors can be hampered by the heterogeneity of primary neuronal cultures. The use of clonal neuroblastoma cell lines
Bullido, María Jesús +5 more
core +1 more source
P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]
, 2008 ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank +6 more
core +1 more source
Human IPSC‐Derived PreBötC‐Like Neurons and Development of an Opiate Overdose and Recovery Model
Advanced Biology, Volume 8, Issue 8, August 2024.Development of an opioid overdose neuronal model. A) A protocol is developed to differentiate Pre‐BötC‐like neurons from human iPSCs. Neuronal response to opioids and rescue by Naloxone is investigated by electrophysiology. B) The spontaneous neural activity is inhibited by opioids and C) dose‐dependent curves are generated for fentanyl and other ...
Xiufang Guo +8 more
wiley +1 more source
Molecular dynamics simulations reveal the role of ceramicine B as novel PPARγ partial agonist against type 2 diabetes [PDF]
arXiv, 2018 Peroxisome proliferator-activated receptors gamma (PPAR{\gamma}) are ligand-activated controllers of various metabolic actions and insulin sensitivity. PPAR{\gamma} is thus considered as an important target to treat type 2 diabetes. Available PPAR{\gamma} drugs (full agonists) have robust insulin-sensitizing properties but are accompanied by severe ...
arxiv
Purinergic Signalling Purinergic Signalling, 2006 This special issue of Purinergic Signalling brings together 12 peer-reviewed reviews and original research papers presented at the first joint Italian-German Purine Club meeting “Progress in Purinergic Receptor Pharmacology and Function” held in Chieti ...
F. Caciagli, F. Di Virgilio
semanticscholar +1 more source