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Bidirectional Interplay Between Microglia and Mast Cells. [PDF]

Int J Mol Sci
Lakatos S, Rosta J.
europepmc   +1 more source

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P2 purinergic receptor antagonists disrupt maternal behavior in lactating rats

Pharmacology Biochemistry and Behavior, 2017
The involvement of purinergic signaling in several brain functions has been recognized, but the modulation on maternal behavior by the purinergic system is not established, even though there are functional interactions between the purinergic and oxytocinergic systems.
Alexandre Giusti-Paiva, Fabiana C Vilela   +1 more
exaly   +3 more sources

P2-purinergic receptor antagonists reduce the minimum alveolar concentration of inhaled volatile anesthetics

Brain Research, 2000
In the central nervous system (CNS), adenosine triphosphate (ATP) is reported to serve as a fast excitatory neurotransmitter via P2X receptor. To examine possible involvement of inhibition of ATP signal-transmission in anesthetic mechanism, the effect of intracerebroventricular (ICV) administration of P2 receptor antagonists on the minimum alveolar ...
E, Masaki, T, Ebisawa, I, Kondo, K, Hayashida, Y, Matsumoto, M, Kawamura   +5 more
openaire   +2 more sources

Comparison of the effects of apamin, a Ca2+-dependent K+ channel blocker, and arylazido aminopropionyl ATP (ANAPP3), a P2-purinergic receptor antagonist, in the guinea-pig vas deferens

European Journal of Pharmacology, 1984
Apamin, which blocks Ca2+-dependent increases in K+ permeability, antagonizes ATP-induced relaxation of several smooth muscles. The ATP photoaffinity label arylazido aminopropionyl ATP (ANAPP3), following its photolysis in the presence of the guinea-pig vas deferens, antagonizes contractile responses to ATP.
J S, Fedan, G K, Hogaboom, J P, O'Donnell   +2 more
openaire   +2 more sources

The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2'4’-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural sensitization caused by repeated amphetamine injections in rats

Neuroscience, 2001
Repeated administration of amphetamine-like psychostimulants produce a progressive and long-lasting hypersensitivity to their behavioural effects known as behavioural sensitization. Previous studies have shown that administration of the purinergic P2 receptor agonist 2-methylthio ATP into the nucleus accumbens of rats raises the extracellular level of ...
H, Kittner, U, Krügel, P, Illes
openaire   +2 more sources

Purinergic P2X7 Receptor: A Therapeutic Target in Amyotrophic Lateral Sclerosis

ACS Chemical Neuroscience, 2022
Michael Kassiou, André D J Mckenzie
exaly  

P2X receptor antagonists and their potential as therapeutics: a patent review (2010–2021)

Expert Opinion on Therapeutic Patents, 2022
William Jörgensen, Leanne Stokes
exaly  

Recent Advances in the Development of Antidepressants Targeting the Purinergic P2X7 Receptor

Current Medicinal Chemistry, 2023
Youngjoo Byun, Jaebong Jang
exaly  

Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

Expert Opinion on Therapeutic Patents, 2019
Aleix Marti Navia, Andrea Spinaci, Volpini Rosaria   +2 more
exaly