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Hippocampal P2X7 and A2A purinoceptors mediate cognitive impairment caused by long-lasting epileptic seizures. [PDF]

open access: yesTheranostics
Sun MJ   +11 more
europepmc   +1 more source
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P2 purinergic receptor antagonists disrupt maternal behavior in lactating rats

Pharmacology Biochemistry and Behavior, 2017
The involvement of purinergic signaling in several brain functions has been recognized, but the modulation on maternal behavior by the purinergic system is not established, even though there are functional interactions between the purinergic and oxytocinergic systems.
Luciana C. Teodoro   +3 more
openaire   +3 more sources

P2-purinergic receptor antagonists reduce the minimum alveolar concentration of inhaled volatile anesthetics

Brain Research, 2000
In the central nervous system (CNS), adenosine triphosphate (ATP) is reported to serve as a fast excitatory neurotransmitter via P2X receptor. To examine possible involvement of inhibition of ATP signal-transmission in anesthetic mechanism, the effect of intracerebroventricular (ICV) administration of P2 receptor antagonists on the minimum alveolar ...
Ichiro Kondo   +5 more
openaire   +3 more sources

Comparison of the effects of apamin, a Ca2+-dependent K+ channel blocker, and arylazido aminopropionyl ATP (ANAPP3), a P2-purinergic receptor antagonist, in the guinea-pig vas deferens

European Journal of Pharmacology, 1984
Apamin, which blocks Ca2+-dependent increases in K+ permeability, antagonizes ATP-induced relaxation of several smooth muscles. The ATP photoaffinity label arylazido aminopropionyl ATP (ANAPP3), following its photolysis in the presence of the guinea-pig vas deferens, antagonizes contractile responses to ATP.
John P. O'Donnell   +2 more
openaire   +3 more sources

The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2'4’-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural sensitization caused by repeated amphetamine injections in rats

Neuroscience, 2001
Repeated administration of amphetamine-like psychostimulants produce a progressive and long-lasting hypersensitivity to their behavioural effects known as behavioural sensitization. Previous studies have shown that administration of the purinergic P2 receptor agonist 2-methylthio ATP into the nucleus accumbens of rats raises the extracellular level of ...
Ute Krügel, Holger Kittner, Peter Illes
openaire   +3 more sources

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