Results 31 to 40 of about 7,019 (140)

Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell

Advanced Biology, Volume 9, Issue 4, April 2025.
By systematizing a large body of evidence and propose a cascade relationship between protein homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction, and pro‐fibrotic factor, providing a theoretical basis for ATII cells dysfunction as a possible pathophysiological initiating event for idiopathic pulmonary fibrosis.
Zhaoxiong Dong, Xiaolong Wang, Peiwen Wang, Mingjian Bai, Tianyu Wang, Yanhui Chu, Yan Qin   +6 more
wiley   +1 more source

Metabolic Dialogue Shapes Immune Response in the Tumor Microenvironment

European Journal of Immunology, Volume 55, Issue 4, April 2025.
Metabolic antagonism in the TME suppresses CD8+ T cell function by depleting essential nutrients and generating toxic byproducts. Metabolic symbiosis between tumor cells and TAMs fosters an immunosuppressive microenvironment. Disrupting metabolic interactions can overcome immune suppression, boost antitumor immunity, and enhance immunotherapy efficacy.
Fengxia Gao, Rushil Shah, Gang Xin, Ruoning Wang   +3 more
wiley   +1 more source

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
Burnstock, G, King, B F, Spyer, K M, Thomas, T, Townsend-Nicholson, A, Wildman, Scott S.P.   +5 more
core   +1 more source

Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This review systematically presents an updated and comprehensive overview of transfusion‐related acute lung injury (TRALI), a serious complication of blood transfusions. It explores TRALI's clinical features, potential causes, and immune mechanisms. Key insights include the roles of signaling pathways and possible therapies, with a focus on prevention ...
Xiaobin Fang, Chunheng Mo, Ling Zheng, Fei Gao, Fu‐Shan Xue, Xiaochun Zheng   +5 more
wiley   +1 more source

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core  

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

British Journal of Pharmacology, Volume 182, Issue 6, Page 1324-1340, March 2025.
Background and Purpose Abdominal pain is a leading cause of morbidity for people living with gastrointestinal disease. Whereas the transient receptor potential vanilloid 4 (TRPV4) ion channel has been implicated in the pathogenesis of abdominal pain, the relative paucity of TRPV4 expression in colon‐projecting sensory neurons suggests that non‐neuronal
Michelle Y. Meng, Luke W. Paine, David Sagnat, Ivana Bello, Sophie Oldroyd, Farideh Javid, Matthew T. Harper, James R. F. Hockley, Ewan St. John Smith, Róisín M. Owens, Laurent Alric, Etienne Buscail, Fraser Welsh, Nathalie Vergnolle, David C. Bulmer   +14 more
wiley   +1 more source

Mechanisms of comorbidity between Alzheimer's disease and pain

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
ABSTRACT Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive and speech impairments, AD patients, especially those in moderate to severe stages, are often overlooked in pain management.
Kaifang Yao, Shenjun Wang, Zhifang Xu, Zezhi Fan, Zhihan Chen, Peng Jia, Shiwei Tu, Yangyang Liu, Xiaowei Lin, Yuan Xu, Yuxing Fang, Baomin Dou, Yi Guo   +12 more
wiley   +1 more source

P2X4 receptor function in the nervous system and current breakthroughs in pharmacology [PDF]

, 2017
ATP is a well-known extracellular signalling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the crystal structure of ...
Abdelrahman, Acuna-Castillo, Agresti, Allsopp, Amadio, Antonio, Asatryan, Asatryan, Asatryan, Ase, Balazs, Banke, Bardoni, Basbaum, Baxter, Bernier, Bhattacharya, Biber, Bintig, Bo, Bobanovic, Boumechache, Bowler, Browne, Buell, Burnstock, Burnstock, Cao, Cardoso, Cham, Chung, Clarke, Coddou, Coddou, Coddou, Cohen, Coull, Davies, de Rivero Vaccari, Di Virgilio, DiSabato, Dixon, Egan, Farber, Ferrini, Fischer, Franke, Franklin, Franklin, Fumagalli, Gao, Garcia-Guzman, Gofman, Gofman, Guo, Hattori, He, Hernandez-Olmos, Horvath, Horvath, Huang, Huynh, Idzko, Igawa, Inoue, Ito, Jabs, Jarvis, Jelinkova, Jo, Joers, Jones, Kawate, Kerr, Kettenmann, Khakh, Khakh, Khakh, Khakh, Khakh, Khoja, Kimpel, Kobayashi, Krause, Krůšek, Kukley, Laing, Lalo, Lalo, Le, Li, Li, Li, Luo, Lê, Mapplebeck, Masuda, Matsumura, Miklavc, Miller, Nagata, Nasu-Tada, Neher, Nicke, North, Nörenberg, Oesterle, Ostrovskaya, Ousingsawat, Ozaki, Pelegrin, Popova, Popova, Potula, Priel, Qureshi, Ransohoff, Raouf, Robinson, Rokic, Royle, Rubio, Saijo, Samways, Samways, Sathanoori, Saul, Schwab, Shinozaki, Shrivastava, Silberberg, Sim, Sim, Sorge, Soto, Soto, Stojilkovic, Stojilkovic, Stokes, Stokes, Surprenant, Tan, Tian, Toulme, Toulme, Toulme, Toyomitsu, Trang, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Ulmann, Ulmann, Ulmann, Vavra, Vazquez-Villoldo, Virginio, Wes, Wheeler-Schilling, Wildman, Wixey, Wyatt, Wyatt, Xiong, Xu, Yamamoto, Yamamoto, Yamashita, Yang, Yardley, Zarei, Zemkova   +174 more
core   +2 more sources

Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine

Advanced Science, Volume 12, Issue 3, January 20, 2025.
Harnessing the robust electromechanical coupling of piezoelectric materials, this review explores their applications in orthopedic medicine, inspired by collagen's natural piezoelectricity in bones. It covers how these materials accelerate osteogenesis, regulate cellular microenvironments through ion channels and signaling pathways, and enhance bone ...
Jingkai Zhang, Chang Liu, Jun Li, Tao Yu, Jing Ruan, Fan Yang   +5 more
wiley   +1 more source

P2X receptors as targets for the treatment of status epilepticus. [PDF]

, 2013
Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a state of continuous seizures that is life-threatening and prompt termination of status epilepticus is critical to protect the brain from permanent damage ...
Diaz-Hernandez, Miguel, Engel, Tobias, Henshall, David C, Miras-Portugal, M Teresa   +3 more
core   +1 more source