Results 31 to 40 of about 7,481 (163)

A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model

Frontiers in Cellular Neuroscience, 2018
Previous studies suggested that the thrombospondin-1/transforming growth factor-β1 (TSP-1/TGF-β1) pathway might be critical in synaptogenesis during development and that the purinergic P2 receptor family could regulate synaptogenesis by modulating TSP-1 ...
Hongliu Sun, Luyu Ma, Yurong Zhang, Xiaohong Pan, Chaoyun Wang, Jinjin Zhang, Xiuli Zhang, Hongwei Sun, Qiaoyun Wang, Wei Zhu   +9 more
doaj   +1 more source

Drug-like antagonists of P2Y receptors — from lead identification to drug development [PDF]

, 2016
P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation.
Conroy, Sean, Kellam, Barrie, Kindon, Nicholas, Stocks, Michael   +3 more
core   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E., Peppiatt-Wildman, Claire M., Schwiebert, E. M., Wildman, Scott S.P.   +3 more
core   +2 more sources

Purinergic modulation of major depressive disorder: Experimental findings, pathogenesis and therapeutic opportunities

Pharmacological Research
Major depressive disorder (MDD) is a mental illness characterized primarily by persistent low mood and anhedonia. Traditional monoamine antidepressants have not achieved entirely satisfactory clinical efficacy.
Xing-Ying Ren, Patrizia Rubini, Tobias Engel, Yong Tang, Peter Illes   +4 more
doaj   +1 more source

P2X4 receptor function in the nervous system and current breakthroughs in pharmacology [PDF]

, 2017
ATP is a well-known extracellular signalling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the crystal structure of ...
Abdelrahman, Acuna-Castillo, Agresti, Allsopp, Amadio, Antonio, Asatryan, Asatryan, Asatryan, Ase, Balazs, Banke, Bardoni, Basbaum, Baxter, Bernier, Bhattacharya, Biber, Bintig, Bo, Bobanovic, Boumechache, Bowler, Browne, Buell, Burnstock, Burnstock, Cao, Cardoso, Cham, Chung, Clarke, Coddou, Coddou, Coddou, Cohen, Coull, Davies, de Rivero Vaccari, Di Virgilio, DiSabato, Dixon, Egan, Farber, Ferrini, Fischer, Franke, Franklin, Franklin, Fumagalli, Gao, Garcia-Guzman, Gofman, Gofman, Guo, Hattori, He, Hernandez-Olmos, Horvath, Horvath, Huang, Huynh, Idzko, Igawa, Inoue, Ito, Jabs, Jarvis, Jelinkova, Jo, Joers, Jones, Kawate, Kerr, Kettenmann, Khakh, Khakh, Khakh, Khakh, Khakh, Khoja, Kimpel, Kobayashi, Krause, Krůšek, Kukley, Laing, Lalo, Lalo, Le, Li, Li, Li, Luo, Lê, Mapplebeck, Masuda, Matsumura, Miklavc, Miller, Nagata, Nasu-Tada, Neher, Nicke, North, Nörenberg, Oesterle, Ostrovskaya, Ousingsawat, Ozaki, Pelegrin, Popova, Popova, Potula, Priel, Qureshi, Ransohoff, Raouf, Robinson, Rokic, Royle, Rubio, Saijo, Samways, Samways, Sathanoori, Saul, Schwab, Shinozaki, Shrivastava, Silberberg, Sim, Sim, Sorge, Soto, Soto, Stojilkovic, Stojilkovic, Stokes, Stokes, Surprenant, Tan, Tian, Toulme, Toulme, Toulme, Toyomitsu, Trang, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Ulmann, Ulmann, Ulmann, Vavra, Vazquez-Villoldo, Virginio, Wes, Wheeler-Schilling, Wildman, Wixey, Wyatt, Wyatt, Xiong, Xu, Yamamoto, Yamamoto, Yamashita, Yang, Yardley, Zarei, Zemkova   +174 more
core   +2 more sources

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Purinergic Receptors in Ocular Inflammation

Mediators of Inflammation, 2014
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease.
Ana Guzman-Aranguez, Xavier Gasull, Yolanda Diebold, Jesús Pintor   +3 more
doaj   +1 more source

Merkel Cells Release Glutamate Following Mechanical Stimulation: Implication of Glutamate in the Merkel Cell-Neurite Complex

Frontiers in Cellular Neuroscience, 2019
Merkel cells (MCs) have been proposed to form a part of the MC-neurite complex with sensory neurons through synaptic contact. However, the detailed mechanisms for intercellular communication between MCs and neurons have yet to be clarified.
Asuka Higashikawa, Maki Kimura, Miyuki Shimada, Sadao Ohyama, Wataru Ofusa, Masakazu Tazaki, Yoshiyuki Shibukawa   +6 more
doaj   +1 more source

Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]

, 2008
Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Dale, Nicholas, Wall, Mark J.
core   +2 more sources

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source