Results 21 to 30 of about 1,542,864 (150)

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ, Eilidh eCraigie, Scott S Wildman, Wildman, Scott S.P., Eilidh Craigie, Rebecca E. Birch, Robert John Unwin, Craigie, Eilidh, Craigie, E, Rebecca E Birch, Unwin, Robert J., Unwin, Robert J, Birch, Rebecca E., Birch, RE, Robert J. Unwin, Wildman, SS, Scott S. Wildman, Birch, Rebecca E, Wildman, Scott   +18 more
core   +1 more source

Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y₁₂ Receptor Antagonists

Molecules, 2019
Large inter-individual variation in platelet response to endogenous agonists and pharmacological agents, including resistance to antiplatelet therapy, prompts a search for novel platelet inhibitors and development new antithrombotic strategies.
Nina Wolska, Magdalena Boncler, Dawid Polak, Joanna Wzorek, Tomasz Przygodzki, Magdalena Gapinska, Cezary Watala, Marcin Rozalski   +7 more
doaj   +1 more source

Purinergic signaling in the gastrointestinal tract [PDF]

, 2011
Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Geoffrey Burnstock, Burnstock, G
core   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

The role of purinergic receptors in stem cell differentiation

Computational and Structural Biotechnology Journal, 2015
A major challenge modern society has to face is the increasing need for tissue regeneration due to degenerative diseases or tumors, but also accidents or warlike conflicts.
Constanze Kaebisch, Dorothee Schipper, Patrick Babczyk, Edda Tobiasch   +3 more
doaj   +1 more source

Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]

, 2015
The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte, Miles, Gareth Brian, Nascimento, Filipe, Miles, Gareth Brian; id_orcid   +3 more
core   +1 more source

A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model

Frontiers in Cellular Neuroscience, 2018
Previous studies suggested that the thrombospondin-1/transforming growth factor-β1 (TSP-1/TGF-β1) pathway might be critical in synaptogenesis during development and that the purinergic P2 receptor family could regulate synaptogenesis by modulating TSP-1 ...
Hongliu Sun, Luyu Ma, Yurong Zhang, Xiaohong Pan, Chaoyun Wang, Jinjin Zhang, Xiuli Zhang, Hongwei Sun, Qiaoyun Wang, Wei Zhu   +9 more
doaj   +1 more source

Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone [PDF]

, 2002
Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials.
Catsicas, M., Peter Mobbs, Pearson, R., Pearson, Rachel; id_orcid, Becker, D., Pearson, R, Rachel Pearson, Becker, D, Mobbs, P, Becker, David, Marina Catsicas, Catsicas, Marina, Catsicas, M, Mobbs, Peter, David Becker, Mobbs, P.   +15 more
core   +1 more source

Viability of SH-SY5Y cells is associated with purinergic P2 receptor expression alterations [PDF]

, 2017
To investigate the role of metabotrophic purinergic P2Y receptors in neuroblastoma cell survival, expression of P2 receptors by normal mouse (C57BL/6) brain and human neuroblastoma SH-SY5Y cells was investigated by Western blot and real time PCR studies.
Tüzün, Erdem, Uğur Akcan, Erten, Gaye, Erdem Tüzün, Yilmaz, Vuslat, Giriş, Murat, Arda Örçen, Örçen, Arda, Vuslat Yilmaz, Gaye Erten, Akcan, Uğur, Murat Giriş   +11 more
core   +1 more source

Purinergic modulation of major depressive disorder: Experimental findings, pathogenesis and therapeutic opportunities

Pharmacological Research
Major depressive disorder (MDD) is a mental illness characterized primarily by persistent low mood and anhedonia. Traditional monoamine antidepressants have not achieved entirely satisfactory clinical efficacy.
Xing-Ying Ren, Patrizia Rubini, Tobias Engel, Yong Tang, Peter Illes   +4 more
doaj   +1 more source