Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E. +3 more
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Experimental inhibition of proliferative retinopathy [PDF]
, 2012 Retinal ischemic diseases like retinopathy of prematurity (ROP), diabetic retinopathy (DRP) and retinal vein occlusion, with preretinal neovascularization (angiogenesis) that may lead to vitreous hemorrhages and retinal detachment with subsequent vision ...
Almlöf Sarman, Sylvia
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Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries [PDF]
, 2014 Background and Purpose: The P2Y14 receptor is the newest member of the P2Y receptor family; it is Gi/o protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5′-diphosphoglucose) (7–10-fold more potent than UDP ...
Alsaqati, M. +3 more
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L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade. [PDF]
, 2016 Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in ...
Allaman, I. +5 more
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IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF GPCR23/LPA4 AS A CANDIDATE G PROTEIN-COUPLED RECEPTOR FOR GUANOSINE [PDF]
, 2014 La guanosina esercita diverse funzioni a livello del Sistema Nervoso Centrale, coinvolgendo recettori di membrana accoppiati a proteine G (GPCR) non ancora identificati.
GRILLO, Maria
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Release of ATP from avian Müller glia cells in culture [PDF]
, 2011 ATP can be released from neurons and act as a neuromodulator in the nervous system. Besides neurons, cortical astrocytes also are capable of releasing ATP from acidic vesicles in a Ca2+-dependent way.
Loiola, Erick Correia +1 more
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Antiplatelet Activity, P2Y1 and P2Y12 Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P1,P4-dithio-P2,P3-chloromethylenetetraphosphate [PDF]
, 2014 Background: Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation.
Barnard, Marc R. +8 more
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P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. [PDF]
, 2012 The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively expressed in neurons and glia in the brain. Activation of the P2X7 receptor has been found to modulate neuronal excitability in the hippocampus and it has ...
Diaz-Hernandez, Miguel +4 more
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UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery [PDF]
, 2018 Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides.
Abbas, Zainab S.B. +6 more
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P2X7R modulation of visually evoked synaptic responses in the retina. [PDF]
, 2016 P2X7Rs are distributed throughout all layers of the retina, and thus, their localisation on various cell types puts into question their specific site(s) of action.
Chavda, S, Luthert, PJ, Salt, TE
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