Results 61 to 70 of about 1,542,864 (150)

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Approaches for designing and discovering purinergic drugs for gastrointestinal diseases [PDF]

, 2020
Introduction: Purines finely modulate physiological motor, secretory, and sensory functions in the gastrointestinal tract. Their activity is mediated by the purinergic signaling machinery, including receptors and enzymes regulating their synthesis ...
Blandizzi C., Pellegrini, Carolina, Lambertucci, Catia, D’Antongiovanni, Vanessa, D'Antongiovanni V., Antonioli, Luca, Dal Ben D., Volpini R., Pellegrini C., Lambertucci C., Fornai M., Spinaci, Andrea, Antonioli L., Fornai, Matteo, Blandizzi, Corrado, Volpini, Rosaria, Spinaci A., Dal Ben, Diego   +17 more
core   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle‐invasive bladder cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Bladder cancer is one of the leading causes of cancer‐related mortality worldwide. Long‐term survival is particularly poor in patients with muscle‐invasive bladder cancer (MIBC). Modulation of purinergic signaling through the ectonucleotidases CD39 and CD73 has emerged as a promising therapeutic strategy in cancer medicine.
Stephan Ledderose, Julia Schwenke, Lennert Eismann, Severin Rodler, Martina Rudelius, Carola Ledderose   +5 more
wiley   +1 more source

Purinergic Signalling: Therapeutic Developments [PDF]

, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock
core   +2 more sources

Purinergic signaling in kidney disease [PDF]

, 2016
Nucleotides are key subunits for nucleic acids and provide energy for intracellular metabolism. They can also be released from cells to act physiologically as extracellular messengers or pathologically as danger signals.
Unwin, RJ, Tam, Frederick W K, Unwin, Robert J, Tam, FW, Menzies, RI, Menzies, Robert, Tam, FWK, Bailey, Matthew; id_orcid, Bailey, MA   +8 more
core   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M., Peppiatt-Wildman, C. M., Wildman, S. S., R. E. Birch, C. M. Peppiatt-Wildman, Scott S Wildman, Schwiebert, E. M., Wildman, Scott S.P., E. M. Schwiebert, S. S. Wildman, Birch, R. E.   +10 more
core   +1 more source

Nicotinic Receptor Activation Occludes Purinergic Control of Central Cardiorespiratory Network Responses to Hypoxia/Hypercapnia

, 2007
Prenatal nicotine exposure alters the cardiorespiratory network responses to hypoxia/hypercapnia; however the mechanism(s) responsible for these cardiorespiratory network responses and their alteration by prenatal nicotine exposure are unknown.
Z. G. Huang, X. Wang, D. Mendelowitz, Kamendi, H., O. Dergacheva, H. Kamendi, Gorini, C., C. Gorini, Dergacheva, O., Huang, Z. G., K. J. S. Griffioen, Wang, X., Mendelowitz, D., Griffioen, K. J.S.   +13 more
core   +1 more source

Comparative analysis of virtual screening approaches in the search for novel EphA2 receptor antagonists [PDF]

, 2015
The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth.
PALA, Daniele, Callegari, Donatella, Scalvini, Laura, Mor, Marco, Lodola, Alessio, Donatella Callegari, Pala, Daniela, Incerti, Matteo, Rivara, Silvia, Daniele Pala, Tognolini, Massimiliano, Marco Mor, Massimiliano Tognolini, Laura Scalvini, Matteo Incerti, Silvia Rivara, Alessio Lodola   +16 more
core   +1 more source