Results 131 to 140 of about 1,391,718 (154)

Targeting P2X Receptors-Current Progress in Sepsis. [PDF]

Int J Inflam
Luo L, Zhao Q, Tian Y, Sun M, Zhang M, Wang B.   +5 more
europepmc   +1 more source

Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening

Bioorganic and Medicinal Chemistry, 2009
The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
Mark J Coster, Michael Kassiou, Hendra Gunosewoyo   +2 more
exaly   +6 more sources

P2X Receptor Antagonists and Their Potential as Therapeutics: A Patent Review (2010–2021)

Expert Opinion on Therapeutic Patents, 2022
Introduction: Purinergic receptors play a critical role in neurotransmission, and modulation of complex physiological functions and thus have implications in numerous disease states.
William Jörgensen, Leanne Stokes
exaly   +2 more sources

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From Tyrosine to Glycine:  Synthesis and Biological Activity of Potent Antagonists of the Purinergic P2X₇Receptor

Journal of Medicinal Chemistry, 2007
The characterization of the native and recombinant P2X7 receptor continues to be hindered by the lack of specific and subtype-selective antagonists with a "druglike" profile. However, a tyrosine derivative named KN-62 exhibits selective P2X7 receptor-blocking properties. As a molecular simplification of KN-62, the present study was designed to evaluate
ROMAGNOLI, Romeo, BARALDI, Pier Giovanni, CARRION MD, CARA CL, PRETI, Delia, CRUZ LOPEZ O, AGHAZADEH TABRIZI, Mojgan, MOORMAN AR, GESSI, Stefania, FOGLI, Eleonora, SACCHETTO, Valeria, BOREA, Pier Andrea   +11 more
openaire   +2 more sources

Synthesis and Biological Activity of N-Arylpiperazine-Modified Analogues of KN-62, a Potent Antagonist of the Purinergic P2X₇ Receptor

Journal of Medicinal Chemistry, 2003
The P2X(7) receptor is involved in several processes relevant to inflammation (cytokine release, NO generation, killing of intracellular pathogens, cytotoxicity); thus, it may be an appealing target for pharmacological intervention. The characterization of native and recombinant P2X(7) receptor continues to be hindered by the lack of specific and ...
BARALDI, Pier Giovanni, M. DEL CARMEN NUNEZ, A. MORELLI, FALZONI, Simonetta, DI VIRGILIO, Francesco, ROMAGNOLI, Romeo   +5 more
openaire   +2 more sources

Contribution of P2X Purinergic Receptor in Cerebral Ischemia Injury

Brain Research Bulletin, 2022
Dong-Xia Hu
exaly  

Dioxotriazine Derivatives as a New Class of P2X3 Receptor Antagonists: Identification of a Lead and Initial SAR Studies

Bioorganic and Medicinal Chemistry Letters, 2021
Tetsuji Itoh, Hiroyuki Kai, Maki Tomari
exaly  

Purinergic Receptor P2X7: A Novel Target for Anti-Inflammatory Therapy

Bioorganic and Medicinal Chemistry, 2014
Om Silakari, Bhawna Vyas, Malkeet Singh Bahia   +2 more
exaly