The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary
Autism Research, Volume 19, Issue 5, May 2026.ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley +1 more source
P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents [PDF]
, 1998 The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Webb, TE +3 more
core
The Molecular Mechanism of P2Y 1 Receptor Activation [PDF]
, 2016 Human purinergic Gprotein-coupled receptor P2Y(1) (P2Y(1)R) is activated by adenosine 5'-diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Crystal structures of P2Y(1)R revealed that one ligand
Chan, H +13 more
core +1 more source
Drug-like Antagonists of P2Y Receptor Subtypes: An Update [PDF]
The hunt for drug-like P2YR antagonists continues, stimulated by ever-increasing pharmacological evidence for their clinical benefit and the astonishing array of biological functions which they orchestrate, including platelet aggregation, cancer ...
Puthanveedu, Mahesh +2 more
core +1 more source
ADP receptor P2Y(13) induce apoptosis in pancreatic beta-cells.
, 2010 Pancreatic beta-cell loss represents a key factor in the pathogenesis of diabetes. Since the influence of purinergic signaling in beta-cell apoptosis has not been much investigated, we examined the role of the ADP receptor P2Y(13) using the pancreatic ...
Erlinge, David, +9 more
core +1 more source
Newer agents in antiplatelet therapy: a review
Journal of Blood Medicine, 2012 Jennifer Yeung, Michael HolinstatCardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USAAbstract: Antiplatelet therapy remains the mainstay in preventing aberrant platelet activation in ...
Yeung J, Holinstat M
doaj
Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]
, 2015 The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte +2 more
core +1 more source
Agonist-induced desensitization of a P2Y-purinergic receptor-regulated phospholipase C. [PDF]
, 1989 A guanine nucleotide-dependent P2Y-purinergic receptor-regulated phospholipase C activity of turkey erythrocyte membranes has been characterized in detail previously (Boyer, J. L., Downes, C. P., and Harden, T. K. (1989) J. Biol. Chem. 264, 884-890). The
Harden, TK, Martin, Michael
core +1 more source
P2X7 Receptor Modulation of Visual Responses in the Retina [PDF]
, 2015 Adenosine 5’ triphosphate (ATP)-gated P2X7 receptors (P2X7Rs) are known to act as conduits for photoreceptor and retinal ganglion cell (RGC) damage, consequences of various neurodegenerative conditions within the visual pathway. Growing evidence supports
Chavda, S
core
Comparative analysis of virtual screening approaches in the search for novel EphA2 receptor antagonists [PDF]
, 2015 The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth.
PALA, Daniele +16 more
core +1 more source