Results 281 to 290 of about 2,313,736 (322)
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Purinergic receptors, prostacyclin and atherosclerosis
Pharmacological Research, 1992Over the last decade, evidence has been provided that endothelial cells have a metabolic function in order to maintain blood vessel homeostasis. The endothelium releases relaxing and contracting factors in response to endogenous or exogenous substances such as acetylcholine, calcimycine, adenosine 5'triphosphate (ATP), bradykinin, arachidonic acid and ...
RAGAZZI, EUGENIO, CHINELLATO A.
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Current Pharmaceutical Design, 2009
There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and
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There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and
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An Introduction to Purinergic Receptors [PDF]
, 1981 Adenosine 5′-triphosphate (ATP) was primarily considered as an intracellular energy source for many years. However, during the past fifty years purine nucleotides and nucleosides have been shown to have potent extracellular actions on excitable membranes which may be involved in physiological regulatory processes (Berne, 1963; Burnstock, 1972, 1975 ...
Geoffrey Burnstock, Christine M. Brown
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Cephalalgia, 2019
Background The current understanding of mechanisms behind migraine pain has been greatly enhanced with the recent therapies targeting calcitonin gene-related peptide and its receptor.
K. Haanes +7 more
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Background The current understanding of mechanisms behind migraine pain has been greatly enhanced with the recent therapies targeting calcitonin gene-related peptide and its receptor.
K. Haanes +7 more
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Purinergic and Glutamatergic Receptors on Astroglia
2014Astroglial cells express many neurotransmitter receptors; the receptors to glutamate and ATP being the most abundant. Here, we provide a concise overview on the expression and main properties of astroglial glutamate receptors (ionotropic receptors represented by AMPA and NMDA subtypes) and metabotropic (mainly mGluR5 and mGluR3 subtypes) and ...
Verkhratsky, A, Burnstock, G
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Purinergic receptors in embryonic and adult neurogenesis
Neuropharmacology, 2016ATP (adenosine 5'-triphosphate), one of the most ancient neurotransmitters, exerts essential functions in the brain, including neurotransmission and modulation of synaptic activity. Moreover, this nucleotide has been attributed with trophic properties and experimental evidence points to the participation of ATP-activated P2X and P2Y purinergic ...
A. Oliveira, P. Illés, H. Ulrich
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Purinergic (P2) Receptors in the Kidney
2003Publisher Summary This chapter focuses on renal P2 receptors and their relationship to the renal effects of adenosine triphosphate (ATP). It also focuses on the nonvascular P2 receptors of renal epithelia. The effects of adenosine on renal function, the distribution of its P1 (A 1–3 subtypes) receptors in kidney tissue, and the potential of this ...
Leipziger, J., Bailey, M.A., Unwin, R.J.
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Purinergic receptors in auditory neurotransmission
Hearing Research, 2003The effects of ATP (adenosine 5' triphosphate) analogs on gross cochlear potentials and single primary afferent discharge properties were studied by intracochlear perfusion in anesthetized guinea pigs. ATP-gamma-S was most potent, with betagammamethylene-ATP and Bz-ATP being significantly less effective.
Bardia Paki +3 more
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Purinergic receptors in gastrointestinal inflammation
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008Purinergic receptors comprise a family of transmembrane receptors that are activated by extracellular nucleosides and nucleotides. The two major classes of purinergic receptors, P1 and P2, are expressed widely in the gastrointestinal tract as well as immune cells.
Rahul Bajaj +3 more
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PET Imaging of Purinergic Receptors
2020Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes is not always fully understood.
Janssen, Bieneke +2 more
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