Results 101 to 110 of about 98,235 (335)
Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, EarlyView.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source
Synthesis of N-7-Substituted Purines from Imidazole Precursors
Molecules, 1999 Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj +1 more source
Untersuchungen zum Ursprung der Substratspezifität von Enzymen der Amidohydrolase‐Superfamilie
Angewandte Chemie, EarlyView.Umfassende Analysen zweier Enzymklassen aus der Amidohydrolase‐Superfamilie (AHS) ergaben, dass die Katalyse über eine 1,4‐ bzw. 1,6‐nukleophile konjugierte Addition abläuft und diese Eigenschaft die Substratspezifität bestimmt. Obwohl alle Substrate und Produkte vollständig achiral sind, führt dieser mechanistische Unterschied zu einer invertierten ...
Lukas Drexler +3 more
wiley +1 more source
Synthesis and fluorescent properties of N(9)-alkylated 2-amino-6-triazolylpurines and 7-deazapurines
Beilstein Journal of Organic Chemistry, 2019 The synthesis of novel fluorescent N(9)-alkylated 2-amino-6-triazolylpurine and 7-deazapurine derivatives is described. A new C(2)-regioselectivity in the nucleophilic aromatic substitution reactions of 9-alkylated-2,6-diazidopurines and 7-deazapurines ...
Andrejs Šišuļins +8 more
doaj +1 more source
Purine Phosphoribosyltransferases [PDF]
Journal of Biological Chemistry, 2000 S P, Craig, A E, Eakin
openaire +2 more sources
On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily
Angewandte Chemie International Edition, EarlyView.Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Lukas Drexler +3 more
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
ReactionsIn this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-b]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%).
Artyom O. Neymash +5 more
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Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation
Molecules, 2015 Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
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Are i‐Motif Structures in DNA Compatible with Cytosine–Ag(I)–Cytosine Base Pairs?
Angewandte Chemie International Edition, EarlyView.An i‐motif/duplex junction was evaluated with respect to its ability to replace the protons from the hemi‐protonated C:CH+ pairs by AgI ions to form C–AgI–C base pairs. Interestingly, only one such metal‐mediated base pair can be formed before the oligonucleotide rearranges into a duplex structure.
Victoria Seiffert +8 more
wiley +1 more source