Results 101 to 110 of about 53,976 (309)
Biotechnology and Bioengineering, EarlyView.The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer +2 more
wiley +1 more source
Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration
ChemBioChem, EarlyView.In tRNA aminoacylated nucleosides represent the central transfer unit of amino acids. An occurring 2′‐3′‐transaminoacylation is biomimetically exploited to successfully synthesize nucleosidic acid esters. This approach can be further expanded on sulfonic acid esters, which has the potential of a broad range of stereo‐ and regio‐controlled modifications
Nathalie J. Kurrle +8 more
wiley +1 more source
STUDIES ON PURINE METABOLISM IN BACTERIA I [PDF]
, 1952 Joseph S. Gots, Eileen Chu
openalex +1 more source
Tailored Watson–Crick Pairing Partners for Xanthosine in RNA
Chemistry – A European Journal, EarlyView.RNAs with kappa‐xanthosine (K–X) or 2‐iminocytidine‐xanthosine (2imC–X) base pairs form stable double helices that have higher melting temperatures than those of the A–U or G–U references. Access to these novel 2imC‐modified RNAs is possible through the mild, selective chemical conversion of 2‐thiocytidine RNA precursors.
Stefan Mair +5 more
wiley +1 more source
Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent
ChemMedChem, Accepted Article.A triplex‐forming oligonucleotide (TFO) can form a sequence‐specific triple helix via Hoogsteen hydrogen bonding to polypurine tracts within a major groove side of a DNA duplex. Triplex formation can induce a double‐strand break, and this phenomenon at the amplified gene loci can selectively induce the cell death of cancer cells with specific gene ...
Haruki Toyama +5 more
wiley +1 more source
Nitrogen-Centered Radicals Derived from Azidonucleosides
MoleculesAzido-modified nucleosides have been extensively explored as substrates for click chemistry and the metabolic labeling of DNA and RNA. These compounds are also of interest as precursors for further synthetic elaboration and as therapeutic agents.
Yahaira Reyes +2 more
doaj +1 more source
Electron Transport Bilayer Design for Perovskite‐Based Tandem Solar Cells Using Thermal Evaporation
Chemistry–Methods, EarlyView.We provide a comprehensive explanation of designing a bi‐layer electron transport layer with a fullerene layer using the evaporation method in inverted perovskite solar cells (PSCs) and perovskite‐based tandem solar cells (PTSCs). Furthermore, we provide candidate materials for a bi‐layer and suggest a fullerene/SnO2 bi‐layer configuration for high ...
Siwon Yun +6 more
wiley +1 more source
ON THE UTILIZATION OF PURINES AND THEIR RIBOSE DERIVATIVES BY YEAST
, 1951 Stanley E. Kerr +2 more
openalex +1 more source
Drug Testing and Analysis, EarlyView.The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt +5 more
wiley +1 more source