Results 101 to 110 of about 53,051 (335)

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani   +6 more
wiley   +1 more source

Using single molecule Molecular Inversion Probes as a cost‐effective, high‐throughput sequencing approach to target all genes and loci associated with macular diseases

open access: yesHuman Mutation, Volume 43, Issue 12, Page 2234-2250, December 2022., 2022
Abstract Macular degenerations (MDs) are a subgroup of retinal disorders characterized by central vision loss. Knowledge is still lacking on the extent of genetic and nongenetic factors influencing inherited MD (iMD) and age‐related MD (AMD) expression.
Rebekkah J. Hitti‐Malin   +15 more
wiley   +1 more source

Solvable models of neighbor-dependent nucleotide substitution processes [PDF]

open access: yesarXiv, 2005
We prove that a wide class of models of Markov neighbor-dependent substitution processes on the integer line is solvable. This class contains some models of nucleotide substitutions recently introduced and studied empirically by molecular biologists. We show that the polynucleotide frequencies at equilibrium solve explicit finite-size linear systems ...
arxiv  

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

open access: yesAnnals of Neurology, EarlyView.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino   +4 more
wiley   +1 more source

Symmetry Analysis Of Genetic Code And Determinative Degree (in Russian) [PDF]

open access: yesarXiv, 2000
A three-dimensional model of the genetic vocabulary is proposed in terms of determinative degree, an introduced characteristic of nucleotide, which reflects absolute difference between purin and pyrimidin bases in one DNA strand. In the fremework of this model manifest symmetry and group properties are described. It is proposed to use the determinative
arxiv  

Purines in Pain as a Gliopathy [PDF]

open access: yesFrontiers in Pharmacology, 2021
Magni, Giulia, Ceruti, Stefania
openaire   +5 more sources

Chemische Proteomik enthüllt menschliche Off‐Targets der durch Fluorchinolone induzierten mitochondrialen Toxizität

open access: yesAngewandte Chemie, EarlyView.
Ein schematischer Überblick über die schädlichen Wirkungen von Ciprofloxacin im Zusammenhang mit mitochondrialer Toxizität. AIFM1 spielt eine Rolle beim MIA40‐vermittelten Import in das IMS und bei der oxidativen Faltung von kernkodierten Proteinen, einschließlich der Untereinheiten der ETC‐Komplexe I und IV.
Till Reinhardt   +14 more
wiley   +1 more source

Editorial: “Purinergic Signaling 2020: The State-of-The-Art Commented by the Members of the Italian Purine Club”

open access: yesFrontiers in Pharmacology, 2021
Francisco Ciruela   +7 more
doaj   +1 more source

Nonlinear Dynamics in the Binary DNA/RNA Coding Problem [PDF]

open access: yesarXiv, 2001
The presence of low dimensional chaos in the protein secondary structures, using the binary coded $\alpha$-helices and $\beta$-sheet motifs, has been investigated. In order to analyse symbolic DNA/RNA sequences the assignment, based on the purine/pyrimidine and strong/wea k H - bond classification sheme, of binary numbers to the nucleotides was made ...
arxiv  

Gut microbiota composition in the sympatric and diet‐sharing Drosophila simulans and Dicranocephalus wallichii bowringi shaped largely by community assembly processes rather than regional species pool

open access: yesiMeta, Volume 1, Issue 4, December 2022., 2022
The diversity, composition, and network of gut microbiota differed between the sympatric and diet‐sharing Drosophila simulans and Dicranocephalus wallichii bowringi. Host species shape the bacterial and fungal community in two insect hosts by altering the relative contribution of community assembly processes.
Yu‐Xi Zhu   +8 more
wiley   +1 more source

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