Pest Management Science, EarlyView.This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King +6 more
wiley +1 more source
Kinetic mechanisms for the sequence dependence of transcriptional errors. [PDF]
Proc Natl Acad Sci U S AMidha T, Kolomeisky AB, Igoshin OA.
europepmc +1 more source
Long‐term remission in gout: Challenges and future opportunities
Rheumatology &Autoimmunity, EarlyView.Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley +1 more source
Rheumatology &Autoimmunity, EarlyView.Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen +6 more
wiley +1 more source
Prostaglandins Regulate Urinary Purines by Modulating Soluble Nucleotidase Release in the Bladder Lumen. [PDF]
Int J Mol SciBorhani Peikani M +3 more
europepmc +1 more source
Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2
Rheumatology &Autoimmunity, EarlyView.Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li +5 more
wiley +1 more source
Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
VIEW, EarlyView.This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li +5 more
wiley +1 more source
DNA base pairs: the effect of the aromatic ring on the strength of the Watson-Crick hydrogen bonding. [PDF]
Org Biomol ChemNieuwland C +7 more
europepmc +1 more source
Below‐ground drivers of rhizosphere functional gene assembly during Moso bamboo expansion
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Moso bamboo (Phyllostachys edulis) expansion threatens subtropical forest biodiversity, yet how intraspecific root trait variation shapes rhizosphere microbial functional potential remains unclear.
Yaoxing Wu +8 more
wiley +1 more source
Purine content of different soybean products and dynamic transfer in food processing techniques. [PDF]
Food Chem XZheng Y +6 more
europepmc +1 more source