Results 131 to 140 of about 53,051 (335)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

A reliable quantitative method for determining CBD content and release from transdermal patches in Franz cells

Phytochemical Analysis, Volume 33, Issue 8, Page 1257-1265, December 2022., 2022
Abstract Introduction There are several cannabidiol (CBD) transdermal patches available on the market. However, none are FDA‐approved. Furthermore, not much evidence has been published about CBD release and skin permeation from such patches, so the effectiveness and reliability remain unclear. Objectives We aimed to develop a method to determine the in
Liyun Yu, Frederikke Bahrt Madsen, Sofie Helvig Eriksen, Aaron J. C. Andersen, Anne Ladegaard Skov   +4 more
wiley   +1 more source

Bilayer Graphene Lateral Contacts for DNA Sequencing [PDF]

arXiv, 2012
Translocation of DNA through a nanopore with embedded electrodes is at the centre of new rapid inexpensive sequencing methods which allow distinguishing the four nucleobases by their different electronic structure. However, the subnanometer separation between nucleotides in DNA requires ultra-sharp probes.
arxiv  

FLOT1 Is a Novel Serum Biomarker of Ovarian Cancer Targeted by N6‐methyladenosine Modification Inhibition

Cell Biology International, EarlyView.
ABSTRACT Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin‐1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the serum level of FLOT1 in OC patients and found that the serum concentration of FLOT1 as well as CA125 was
Bin Guan, Qi Lu, Junyu Chen, Jingyi Fang, Zhenyu Liu, Wei Li, Lingyun Zhang, Guoxiong Xu   +7 more
wiley   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

BIOSYNTHESIS OF THE PURINES

, 1957
Leonard Warren, John M. Buchanan
openalex   +2 more sources

A proteome‐scale analysis of vertebrate protein amino acid occurrence: Thermoadaptation shows a correlation with protein solvation but less so with dynamics

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 1, Page 3-15, January 2023., 2023
Abstract Despite differences in behaviors and living conditions, vertebrate organisms share the great majority of proteins, often with subtle differences in amino acid sequence. Here, we present a simple way to analyze the difference in amino acid occurrence by comparing highly homologous proteins on a subproteome level between several vertebrate model
Zhen‐Lu Li, Matthias Buck
wiley   +1 more source

A Cytotoxic Indazole‐based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation

Chemistry – A European Journal, EarlyView.
Toward new gold(III) anticancer agents. Herein, we report on an indazole‐based gold(III) carboxamide pincer complex exhibiting significant cytotoxicity, likely mediated through dual interactions with DNA. Mechanistic investigations suggest that the complex binds to the DNA and forms specific interactions with nucleotide bases.
Rufaro Razuwika, Sheldon Sookai, Ruth Aronson, Mandeep Kaur, Orde Q. Munro   +4 more
wiley   +1 more source

Design and Evaluation of Bivalent K‐Ras Inhibitors that Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

Chemistry – A European Journal, Accepted Article.
Mutant K‐Ras drives cancer through its membrane localization, which requires post‐translational modification by farnesyltransferase (FTase). FTase attaches farnesyl to the K‐Ras C‐terminal CVIM tetrapeptide, enabling membrane binding. However, K‐Ras can also undergo compensatory geranylgeranylation by geranylgeranyltransferase I (GGTase I), making ...
Junko Ohkanda, Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Naomi Ogino, Yoshihisa Inoue, Kazi Aslamuzzaman, Takeyuki Suzuki, Said Sebti   +8 more
wiley   +1 more source

Editorial: The role of astrocyte signalling pathways in ageing-induced neurodegenerative pathologies

Frontiers in Physiology, 2022
Nady Braidy, Bilal Cig, Bilal Cig, Lin-Hua Jiang, Lin-Hua Jiang, Lin-Hua Jiang, Xinhua Shu, Xinhua Shu   +7 more
doaj   +1 more source