Results 131 to 140 of about 36,659 (205)
Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors
British Journal of Pharmacology, EarlyView.Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen +3 more
wiley +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li +9 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin +13 more
wiley +1 more source
New Anti‐Fibrotic Strategies for Keloids: Insights From Single‐Cell Multi‐Omics
Cell Proliferation, EarlyView.Our research not only revealed the ubiquity and activity of POSTN‐positive mesenchymal fibroblasts in keloids but also discovered the predominant role of IGFBP2‐positive fibroblasts in normal skin and their potential significance in the process of anti‐fibrotic therapy.
Songyun Zhao +16 more
wiley +1 more source
Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging
Cell Proliferation, EarlyView.Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi +6 more
wiley +1 more source
The Purines and Purine Metabolism of the Human Fetus and Placenta
Journal of Biological Chemistry, 1909 Harry J. Corper, H. Gideon Wells
openaire +2 more sources
The transformation of purines into pteridines [PDF]
Biochemical Journal, 1957 openaire +4 more sources
IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target
Cell Proliferation, EarlyView.IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li +8 more
wiley +1 more source