Results 141 to 150 of about 53,051 (335)

A Robust Strategy for Introducing Amino‐Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA

open access: yesChemistry – A European Journal, EarlyView.
We report a simple, efficient, and cost‐effective methodology for introducing amino‐modifiers into DNA and RNA using a commercially available solid support. By incorporating a base‐labile sulfonyl linker within the strand, we developed an amino‐containing tandem oligonucleotide synthesis (aTOS) methodology, which enables the introduction of multiple ...
Jagandeep S. Saraya   +3 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

open access: yes, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

The Photophysics of Nucleic Acids: Consequences for the Emergence of Life

open access: yesChemSystemsChem, Volume 5, Issue 1, January 2023., 2023
Photochemical reactions in nucleic acids induced by ultraviolet (UV) radiation could have played an important role in the prebiotic selection of the building blocks of life. This Review summarizes the quantum efficiencies of the photorelaxation pathways of nucleic acids and discusses its implications for the emergence of an initial sequence pool on ...
Corinna L. Kufner   +2 more
wiley   +1 more source

Researches on Purines

open access: hybrid, 1911
Carl O. Johns
openalex   +1 more source

Light‐responsive mononucleotide coacervates

open access: yesChemistry – A European Journal, Accepted Article.
Liquid‐liquid phase separation (LLPS) is central to the formation of biomolecular condensates in modern cells and is also explored as a mechanism for assembling protocells. Phase‐separated droplets provide dynamic micro‐environments that concentrate reactants, enhance reactions, and allow molecular exchange, essential for both cellular regulation and ...
Edison Rafael Jimenez Granda   +4 more
wiley   +1 more source

RNA Oligomerisation without Added Catalyst from 2′,3′‐Cyclic Nucleotides by Drying at Air‐Water Interfaces**

open access: yesChemSystemsChem, Volume 5, Issue 1, January 2023., 2023
Without catalyst! A non‐enzymatic, spontaneous route to the formation of short, mixed‐sequence RNA strands from 2′,3′‐cyclic ribonucleotides is shown. The reaction occurs by drying at the air–water interfaces. Abstract For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step.
Avinash Vicholous Dass   +16 more
wiley   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

open access: yesChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber   +3 more
wiley   +1 more source

Water‐Soluble Pd‐Imidate Complexes as Versatile Catalysts for the Modification of Unprotected Halonucleosides

open access: yesThe Chemical Record, Volume 22, Issue 12, December 2022., 2022
Three generations of neutral and anionic water‐soluble palladium complexes act as versatile catalysts for the modification of unprotected halonucleosides. Abstract Modification of unprotected nucleosides has been attracting continuous interest, since these building blocks themselves and their phosphate‐upgraded corresponding nucleotides have shown a ...
José Luis Serrano
wiley   +1 more source

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