Results 181 to 190 of about 53,051 (335)

Moderate hyperuricaemia ameliorated kidney damage in a low‐renin model of experimental renal insufficiency

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 21-32, January 2023., 2023
Abstract Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated oxidative stress. We studied the influence of experimental hyperuricaemia in surgically 5/6 nephrectomized rats. Three weeks after subtotal nephrectomy or sham operation, the rats were allocated
Venla Kurra, Arttu Eräranta, Timo Paavonen, Teemu Honkanen, Juhani Myllymäki, Asko Riutta, Ilkka Tikkanen, Päivi Lakkisto, Jukka Mustonen, Ilkka Pörsti   +9 more
wiley   +1 more source

Refuse in order to resist: metabolic bottlenecks reduce antibiotic susceptibility. [PDF]

Mol Syst Biol
Kanaris O, Schreiber F.
europepmc   +1 more source

THE ENZYMATIC SYNTHESIS OF PURINE RIBOSIDES

, 1947
Herman Μ. Kalckar
openalex   +1 more source

Novel machine‐learning bioinformatics reveal distinct metabolic alterations for enhanced colorectal cancer diagnosis and monitoring

iMetaOmics, EarlyView.
The PANDA pipeline for colorectal cancer (CRC) analysis integrates metabolomic data from LC‐MS with machine learning techniques to classify CRC stages and predict biomarkers. Initially, the raw metabolomic data is processed using partial least squares discriminant analysis (PLS‐DA) to reduce dimensionality and highlight key features.
Rui Xu, Hyein Jung, Fouad Choueiry, Shiqi Zhang, Rachel Pearlman, Heather Hampel, Ning Jin, Jieli Li, Jiangjiang Zhu   +8 more
wiley   +1 more source

Hypothesis review: Alzheimer's overture guidelines

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Brain aging with ADNC and sporadic Alzheimer's disease (sAD) form a prevalent continuum unique to humans. Molecular changes affecting cell membranes, cytoskeleton, synapses, lipid and protein metabolism, energy metabolism, neuroinflammation, cell cycle, astrocytes, microglia, and blood vessels precede and occur in parallel with early ADNC; and they are
Isidro Ferrer
wiley   +1 more source

The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development. [PDF]

Molecules
Mileti LN, Baleja JD.
europepmc   +1 more source

Sex‐specific associations of Roseburia with uric acid metabolism and hyperuricemia risk in females

iMetaOmics, EarlyView.
Researchers recruited 623 participants, including 270 females, and used 16S rDNA sequencing to investigate gender differences in hyperuricemia. In healthy females, Roseburia was enriched, positively correlating with estrogen and negatively with uric acid, suggesting it is a potential biomarker affecting uric acid levels in females.
Zhihan Yang, Zeng Zhang, Mohan Chen, Jin Hu, Yingqi Qiu, Shijia Lin, Xiaolu Zhou, Jiachao Zhang, Shuaiming Jiang   +8 more
wiley   +1 more source

Untargeted Metabolomics and Liquid Biopsy Investigation of Circulating Biomarkers in Soft Tissue Sarcoma. [PDF]

Cancers (Basel)
Grasso D, Marzocchi B, Scoccianti G, Palchetti I, Campanacci DA, Antonuzzo L, Scolari F, Pillozzi S, Bernini A.   +8 more
europepmc   +1 more source

Understanding the genetic complexity of Leishmania infantum in the Americas: a focus on 3'NT/NU gene deletion. [PDF]

Mem Inst Oswaldo Cruz
Florêncio M, Cupolillo E, Boité MC.
europepmc   +1 more source

PURINE FERMENTATION BY CLOSTRIDIUM CYLINDROSPORUM

, 1956
Jesse C. Rabinowitz, H.A. Barker
openalex   +1 more source