Results 201 to 210 of about 53,976 (309)
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
British Journal of Pharmacology, EarlyView.Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley +1 more source
The Purines and Purine Metabolism of the Human Fetus and Placenta
Journal of Biological Chemistry, 1909 Harry J. Corper, H. Gideon Wells
openaire +2 more sources
Clinical Genetics, EarlyView.Our mouse model with a c.259G>A transition in PRPS1 showed a significant decrease in the number of hair cells and SGN counts at 48 weeks of age and a reduction in Prps1 enzymatic activity in the KI mouse. This model will serve as a valuable tool for developing therapeutic strategies.
Denise Yan +6 more
wiley +1 more source
The Avoidance of Purine Stretches by Cancer Mutations. [PDF]
Int J Mol SciVikhorev AV +6 more
europepmc +1 more source
Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging
Cell Proliferation, EarlyView.Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi +6 more
wiley +1 more source
Understanding the genetic complexity of Leishmania infantum in the Americas: a focus on 3'NT/NU gene deletion. [PDF]
Mem Inst Oswaldo CruzFlorêncio M, Cupolillo E, Boité MC.
europepmc +1 more source
THE RELATIONSHIP OF FOLIC ACID TO FORMATE METABOLISM IN THE RAT: FORMATE INCORPORATION INTO PURINES
, 1951 George R. Drysdale +2 more
openalex +1 more source
The FEBS Journal, EarlyView.A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley +1 more source
Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions. [PDF]
Sci RepBirder LA +6 more
europepmc +1 more source