Results 21 to 30 of about 53,051 (335)

Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1H)-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90

open access: yesMolecules, 2022
In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90 inhibitors, we designed and synthesized a novel series of 3-(heteroaryl)quinolin-2(1H), of types 3, 4, and 5, as a novel class of analogues.
Enrique L. Larghi   +5 more
doaj   +1 more source

Magnetic circular dichroism within the Algebraic Diagrammatic Construction scheme of the polarisation propagator up to third order [PDF]

open access: yes, 2022
We present an implementation of the B term of Magnetic Circular Dichroism within the Algebraic Diagrammatic Construction (ADC) scheme of the polarization propagator and its Intermediate State Representation. As illustrative results, the MCD spectra of the ADC variants ADC(2), ADC(2)-x and ADC(3) of the molecular systems uracil, 2-thiouracil, 4 ...
arxiv   +1 more source

Meat quality of rabbits reared with two different feeding strategies: with or without fresh alfalfa ad libitum

open access: yesWorld Rabbit Science, 2013
The aim of this study was to evaluate production performance, carcass characteristics and nutritive value of meat of rabbits reared under the 2 prevailing feeding strategies in Uruguay.
Gustavo Capra   +6 more
doaj   +1 more source

Último recuento: una estrategia efectiva para la evaluación de indicadores de germinación en especies forrajeras en situaciones de estrés

open access: yesCiencia y Tecnología Agropecuaria, 2023
Existen pruebas estandarizadas para evaluar la calidad de las semillas y para ensayos de biomonitoreo ambiental, las cuales utilizan indicadores que permiten establecer la sensibilidad de diversas especies a condiciones ambientales, aunque los momentos ...
Lorna Ileana Carbó   +4 more
doaj   +1 more source

A Generalization of the Auslander-Reiten Conjecture for the Bounded Derived Category [PDF]

open access: yesArchiv der Mathematik: Volume 98, Issue 6 (2012), Page 507-511, 2011
We study the bounded derived category $\D^b(\Rmod)$ of a left Noetherian ring $R$. We give a version of the Generalized Auslander-Reiten Conjecture for $\D^b(\Rmod)$ that is equivalent to the classical statement for the module category and is preserved under derived equivalence.
arxiv   +1 more source

Genetic Screen Reveals the Role of Purine Metabolism in Staphylococcus aureus Persistence to Rifampicin

open access: yesAntibiotics, 2015
Chronic infections with Staphylococcus aureus such as septicemia, osteomyelitis, endocarditis, and biofilm infections are difficult to treat because of persisters.
Rebecca Yee   +4 more
doaj   +1 more source

2,6-Bis[4-(4-butylphenyl)-1H-1,2,3-triazol-1-yl]-9-dodecyl-9H-purine

open access: yesMolbank, 2019
Target 2,6-bis[4-(4-butylphenyl)-1H-1,2,3-triazol-1-yl]-9-dodecyl-9H-purine has been prepared via a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction between 2,6-diazido-9-dodecyl-9H-purine and 4-n-butyl(phenylacetylene) in a 29% yield. The
Andrejs Šišuļins   +3 more
doaj   +1 more source

Scientific investigations of the Nobel prize winner Emil Fischer as a launching pad for the development of biochemistry: a brief overview [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2018
Modern biochemistry and molecular biology would be impossible without discoveries in related fields of science. This paper aims to outline briefly the main stages of scientific activity of a Nobel Prize winner 1902 – German chemist Hermann Emil Fischer ...
T. V. Danylova, S. V. Komisarenko
doaj   +1 more source

Metabolomic and transcriptomic response to imatinib treatment of gastrointestinal stromal tumour in xenograft-bearing mice

open access: yesTranslational Oncology, 2023
Background: Although imatinib is a well-established first-line drug for treating a vast majority of gastrointestinal stromal tumours (GIST), GISTs acquire secondary resistance during therapy.
Szymon Macioszek   +8 more
doaj  

Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease

open access: yesFrontiers in Endocrinology, 2018
The maintenance of a healthy deoxyribonucleotide triphosphate (dNTP) pool is critical for the proper replication and repair of both nuclear and mitochondrial DNA.
Raquel Buj, Katherine M. Aird
doaj   +1 more source

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