Results 21 to 30 of about 53,976 (309)
Purine Acquisition and Synthesis by Human Fungal Pathogens
Microorganisms, 2017 While members of the Kingdom Fungi are found across many of the world’s most hostile environments, only a limited number of species can thrive within the human host. The causative agents of the most common invasive fungal infections are Candida albicans,
Jessica L. Chitty, James A. Fraser
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Ciencia y Tecnología Agropecuaria, 2023 Existen pruebas estandarizadas para evaluar la calidad de las semillas y para ensayos de biomonitoreo ambiental, las cuales utilizan indicadores que permiten establecer la sensibilidad de diversas especies a condiciones ambientales, aunque los momentos ...
Lorna Ileana Carbó +4 more
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Revista Brasileira de Zootecnia, 2010 Objetivou-se analisar a variação do pH, da amônia ruminal e do balanço de compostos nitrogenados e a síntese de proteína microbiana de 12 vacas da raça Holandesa distribuídas em três quadrados latinos 4 × 4, alimentadas com dietas contendo soja em ...
Angela Maria de Vasconcelos +5 more
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Basis for the control of purine biosynthesis by purine ribonucleotides. [PDF]
Journal of Clinical Investigation, 1981 An animal model was used to determine the basis for the increase in purine biosynthesis that results from hepatic depletion of purine nucleotides, such as seen in patients with type I glycogen storage disease or following fructose administration. Mice were injected intravenously with glucose or fructose, 2.5 mg/g of body weight, and the animals were ...
Edward W. Holmes +3 more
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Scientific investigations of the Nobel prize winner Emil Fischer as a launching pad for the development of biochemistry: a brief overview [PDF]
The Ukrainian Biochemical Journal, 2018 Modern biochemistry and molecular biology would be impossible without discoveries in related fields of science. This paper aims to outline briefly the main stages of scientific activity of a Nobel Prize winner 1902 – German chemist Hermann Emil Fischer ...
T. V. Danylova, S. V. Komisarenko
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Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis
CellsInflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the ...
Corey S. Worledge +5 more
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P2X7 Receptor Upregulation in Huntington’s Disease Brains
Frontiers in Molecular Neuroscience, 2020 Huntington’s disease (HD) is a fatal degenerative disorder affecting the nervous system. It is characterized by motor, cognitive, and psychiatric dysfunctions, with a late onset and an autosomal dominant pattern of inheritance.
Ivana Ollà +7 more
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Modifiable nutritional factors in hyperuricemia and gout
Alʹmanah Kliničeskoj Mediciny, 2022 Uric acid is an independent risk factor for socially important diseases, such as chronic heart failure and chronic kidney disease. The review summarizes current data on the impact of nutrition as a presumably modifiable factor into the development of ...
Olga A. Georginova +2 more
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Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
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Synthesis of Pyridinium Moiety Containing Triazolyl Purines
MolbankPyridinium salts of 2-piperidinyl-6-triazolylpurine derivatives were obtained by the introduction of pyridinium moieties into the propane-1,3-diol fragment at the N(9) position of purine to enhance the solubility of 2-amino-6-triazolylpurine derivatives ...
Aleksejs Burcevs +2 more
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