Results 21 to 30 of about 98,235 (335)

PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

Cell Reports, 2017
Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Boxi Zhang, Adi Zheng, Per Hydbring, Gorbatchev Ambroise, Amanda Tomie Ouchida, Michel Goiny, Helin Vakifahmetoglu-Norberg, Erik Norberg   +7 more
doaj   +1 more source

P2X7 Receptor Upregulation in Huntington’s Disease Brains

Frontiers in Molecular Neuroscience, 2020
Huntington’s disease (HD) is a fatal degenerative disorder affecting the nervous system. It is characterized by motor, cognitive, and psychiatric dysfunctions, with a late onset and an autosomal dominant pattern of inheritance.
Ivana Ollà, Ivana Ollà, María Santos-Galindo, María Santos-Galindo, Ainara Elorza, Ainara Elorza, José J. Lucas, José J. Lucas   +7 more
doaj   +1 more source

Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides

Frontiers in Molecular Neuroscience, 2021
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted
Edward Beamer, Edward Beamer, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Aisling A. Garvey, Aisling A. Garvey, Jonathon Smith, Jonathon Smith, Aida Menéndez-Méndez, Lynne Kelly, Lynne Kelly, Andreea Pavel, Andreea Pavel, Sean Quinlan, Mariana Alves, Eva M. Jimenez-Mateos, Faming Tian, Eugene Dempsey, Eugene Dempsey, Nicholas Dale, Deirdre M. Murray, Deirdre M. Murray, Geraldine B. Boylan, Geraldine B. Boylan, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Tobias Engel, Tobias Engel   +31 more
doaj   +1 more source

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

Cardiovascular Pharmacology of Purines [PDF]

Clinical Science, 1997
1. This review focuses on the extracellular actions of ATP and adenosine, and in particular their role in cardiovascular regulation. 2. ATP serves as a co-transmitter within the sympathetic nervous system, and is also released from endothelium and aggregating thrombocytes.
Rongen, G.A.P.J.M., Floras, J.S., Lenders, J.W.M., Thien, Th., Smits, P.   +4 more
openaire   +4 more sources

Teores de proteína bruta para bovinos alimentados com feno de capim-tifton 85: parâmetros ruminais, eficiência de síntese microbiana e degradabilidade in situ Effects of crude protein levels on microbial efficiency and in situ degradability in steers fed Tifton 85 bermudagrass hay supplemented with different protein sources

Revista Brasileira de Zootecnia, 2007
Avaliou-se o efeito da deficiência de PB na dieta sobre a eficiência de síntese microbiana e a degradabilidade in situ da MS e FDN em novilhos mestiços.
Edilane Aparecida da Silva, Telma Teresinha Berchielli, Ricardo Andrade Reis, Alexandre Vaz Pires, Kátia Junko Sato, José Mauro Valente Paes, André Dias Lopes   +6 more
doaj   +1 more source

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum, Blackburn, Gavin, Daskalaki, Evangelia, Kalna, Gabriela, Watson, David, Zhang, Tong   +5 more
core   +2 more sources

Partial (13)C isotopic enrichment of nucleoside monophosphates: useful reporters for NMR structural studies [PDF]

, 2005
Analysis of the (13)C isotopic labeling patterns of nucleoside monophosphates (NMPs) extracted from Escherichia coli grown in a mixture of C-1 and C-2 glucose is presented. By comparing our results to previous observations on amino acids grown in similar
Kishore, Anita I., Mayer, Michael R., Prestegard, James H.   +2 more
core   +2 more sources

The changes in purine metabolism in gastric cancer

Gastroenterologìa, 2019
Background. Gastric cancer (GC) is considered an urgent problem of oncology, due to its high incidence and morta­lity, diagnosis at a later stage of the disease progression, anatomical and topographical features of the organ affected by the tumor and the
O.V. Syniachenko, R.F. Aliiev, M.V. Iermolaieva, V.G. Bondar   +3 more
doaj   +1 more source

Linear model for fast background subtraction in oligonucleotide microarrays [PDF]

, 2009
One important preprocessing step in the analysis of microarray data is background subtraction. In high-density oligonucleotide arrays this is recognized as a crucial step for the global performance of the data analysis from raw intensities to expression ...
Barkema, Gerard T., Carlon, Enrico, Kroll, K. Myriam   +2 more
core   +4 more sources