Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Wall, Mark J. +2 more
core +2 more sources
Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]
, 1987 Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
core +2 more sources
Electronic Spectroscopy of Isolated DNA Polyanions [PDF]
, 2018 In solution, UV-vis spectroscopy is often used to investigate structural changes in biomolecules (i.e., nucleic acids), owing to changes in the environment of their chromophores (i.e., the nucleobases).
Daly, Steven +3 more
core +3 more sources
The exercise sex gap and the impact of the estrous cycle on exercise performance in mice
Scientific Reports, 2018 Exercise physiology is different in males and females. Females are poorly studied due to the complexity of the estrous cycle and this bias has created an exercise sex gap.
Aderbal S. Aguiar +4 more
doaj +1 more source
A New Class of Nucleosides. Synthesis, Reactivity and Biological Activity of Keto-Hexose Nucleosides
CHIMIA, 1975 Direct oxydation of sterically hindered hexosyl purines led to keto-hexosylpurines, important synthetic intermediates. The first unsaturated keto-nucleosides have also been obtained by acetylation of the corresponding keto-hexosyl purines.
K. Antonakis
doaj +1 more source
Purinergic Signalling in Inflammatory Renal Disease
Frontiers in Physiology, 2013 Extracellular purines have a role in renal physiology and adaption to inflammation. However, inflammatory renal disease may be mediated by extracellular purines, resulting in renal injury.
Nishkantha eArulkumaran +6 more
doaj +1 more source
P2X7 Receptor Upregulation in Huntington’s Disease Brains
Frontiers in Molecular Neuroscience, 2020 Huntington’s disease (HD) is a fatal degenerative disorder affecting the nervous system. It is characterized by motor, cognitive, and psychiatric dysfunctions, with a late onset and an autosomal dominant pattern of inheritance.
Ivana Ollà +7 more
doaj +1 more source
Surface-enhanced Raman spectroscopy of DNA bases [PDF]
, 1986 A Raman microprobe has been used to measure the surface-enhanced Raman spectra of adenine, guanine, cytosine and thymine. Comparison of the SERS spectrum with solution spectra shows that some line positions are not influenced by the adsorption process ...
Greve, J. +3 more
core +3 more sources
Elevated Level of DNA Damage and Impaired Repair of Oxidative DNA Damage in Patients with Recurrent Depressive Disorder [PDF]
, 2015 Background: Depressive disorder (DD), including recurrent DD (rDD), is a severe psychological disease, which affects a large percentage of the world population.
Bielecka-Kowalska, Anna +9 more
core +1 more source
PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis
Cell Reports, 2017 Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Boxi Zhang +7 more
doaj +1 more source