Results 21 to 30 of about 50,189 (192)

Metabolomic and transcriptomic response to imatinib treatment of gastrointestinal stromal tumour in xenograft-bearing mice

Translational Oncology, 2023
Background: Although imatinib is a well-established first-line drug for treating a vast majority of gastrointestinal stromal tumours (GIST), GISTs acquire secondary resistance during therapy.
Szymon Macioszek, Danuta Dudzik, Rafał Bartoszewski, Tomasz Stokowy, Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Patrick Schöffski, Michał J. Markuszewski   +8 more
doaj   +1 more source

The changes in purine metabolism in gastric cancer

Gastroenterologìa, 2019
Background. Gastric cancer (GC) is considered an urgent problem of oncology, due to its high incidence and morta­lity, diagnosis at a later stage of the disease progression, anatomical and topographical features of the organ affected by the tumor and the
O.V. Syniachenko, R.F. Aliiev, M.V. Iermolaieva, V.G. Bondar   +3 more
doaj   +1 more source

Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis

Cells
Inflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the ...
Corey S. Worledge, Rachael E. Kostelecky, Liheng Zhou, Geetha Bhagavatula, Sean P. Colgan, J. Scott Lee   +5 more
doaj   +1 more source

Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides

Frontiers in Molecular Neuroscience, 2021
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted
Edward Beamer, Edward Beamer, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Aisling A. Garvey, Aisling A. Garvey, Jonathon Smith, Jonathon Smith, Aida Menéndez-Méndez, Lynne Kelly, Lynne Kelly, Andreea Pavel, Andreea Pavel, Sean Quinlan, Mariana Alves, Eva M. Jimenez-Mateos, Faming Tian, Eugene Dempsey, Eugene Dempsey, Nicholas Dale, Deirdre M. Murray, Deirdre M. Murray, Geraldine B. Boylan, Geraldine B. Boylan, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Tobias Engel, Tobias Engel   +31 more
doaj   +1 more source

Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group

, 1997
Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding 'DABCO-purines' I (X = NH2, H, Cl, Y = H; X = NH2, Y = β-D-ribofuranosyl), which undergo facile displacement reactions with alkoxides in DMSO to afford 6-oxy ...
Clegg, William, Heath, Sarah L; id_orcid, Grant, Sharon, Golding, Bernard T, Lembicz, Nicola K, Griffin, Roger J, Sarah L. Heath, Roger J. Griffin, Bernard T. Golding, Nicola K. Lembicz, Sharon Grant, William Clegg   +11 more
core   +7 more sources

Chemistry of fluorinated purines

, 2014
Fluorinated purines and related nucleosides exhibit a diverse range of biological activities. The presence of a single fluoro or trifluoromethyl group at the 2-, 6-, or 8-position of a purine or purine nucleoside, or combinations of multiple ...
Winship, Paul C. M., Ian Collins, Collins, Ian, Alan M. Jones, Jones, Alan M.; id_orcid, John J. Caldwell, Paul C. M. Winship, Caldwell, John J.   +7 more
core   +1 more source

Benzoxazine–Purine Hybrids as Antiproliferative Agents: Rational Design and Divergent Mechanisms of Action

Pharmaceutics
Background/Objectives: Targeted cancer therapies increasingly rely on modulating specific cell death pathways and kinase signaling. Due to their structural versatility and potential to induce mechanistically distinct cytotoxic responses, benzoxazine ...
Houria Boulaiz, Yaiza Jiménez-Martínez, Francisco Franco-Montalbán, Jesús Peña-Martín, Ana Conejo-García, M. Dora Carrión   +5 more
doaj   +1 more source

Pyrimidines- and purines-rich sequences of miRNAs.

, 2016
The table shows the content of the pyrimidines or purines nucleotides according to the sequence of miRNAs. The total contents of purines or pyrimidines of the miRNAs presented in the table is above 90%.
Jan Barciszewski (55070), Dariusz Wawrzyniak (2587537), Agnieszka Belter (665923), Monika Piwecka (665925), Miroslawa Z. Barciszewska (2587531), Katarzyna Rolle (95323), Jaroslaw Jeleniewicz (2587534)   +6 more
core   +1 more source

Direct C−H Arylation of Purines:  Development of Methodology and Its Use in Regioselective Synthesis of 2,6,8-Trisubstituted Purines

, 2016
Direct C−H arylation of purines to position 8 by diverse aryl iodides was achieved with Pd catalysis in the presence of CuI and Cs2CO3. The methodology is general and efficient and was applied in the consecutive regioselective synthesis of 2,6,8 ...
Michal Hocek (1365984), Igor Čerňa (2520637), Radek Pohl (1365981), Blanka Klepetářová (2478466)   +3 more
core   +4 more sources

Cardiovascular Pharmacology of Purines [PDF]

Clinical Science, 1997
1. This review focuses on the extracellular actions of ATP and adenosine, and in particular their role in cardiovascular regulation. 2. ATP serves as a co-transmitter within the sympathetic nervous system, and is also released from endothelium and aggregating thrombocytes.
Rongen, G.A.P.J.M., Floras, J.S., Lenders, J.W.M., Thien, Th., Smits, P.   +4 more
openaire   +4 more sources