Results 231 to 240 of about 126,114 (304)

Rapid imaging of pulmonary metastasis from colorectal cancer with a red fluorescence probe targeting puromycin-sensitive aminopeptidase and dipeptidyl peptidase IV. [PDF]

Sci Rep
Kobayashi K, Fujita K, Kojima R, Hino R, Urano Y, Sato M.   +5 more
europepmc   +1 more source

Puromycin-Sensitive Aminopeptidase [PDF]

, 2020
openaire   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Establishment of a transgenic protocol in <i>Trichoplax adhaerens</i>. [PDF]

Zool Res
Jin MJ, Ji ZY, Zhao ZY, Guo QY, Di GT, Li WQ, Zhao CT.   +6 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Selective Enrichment and Identification of Cerebrospinal Fluid-Contacting Neurons In Vitro via PKD2L1 Promoter-Driven Lentiviral System. [PDF]

Bio Protoc
Tan W, Shangguan Z, Jing S, Shi X, Li Q, Li H, Zhang H, Luo Z, Wang C, Dou X, Li Q.   +10 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling. [PDF]

Int J Mol Sci
Cipriano GL, Floramo A, Argento V, Oddo S, Artimagnella O.   +4 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

The effects of <i>Salmonella enterica</i> cell extract on the gene expression of bleomycin hydrolase, puromycin-sensitive aminopeptidase, and thimet oligopeptidase in human colorectal adenocarcinoma cells. [PDF]

Iran J Microbiol
Mardani R, Borhaniasl M, Ghatee MA, Khosravani SA, Sharifi K, Jahanbin K, Sharifi A.   +6 more
europepmc   +1 more source