Results 221 to 230 of about 122,814 (265)

Synthesis of L,L‐Puromycin.

ChemInform, 2005
Abstract l , l -Puromycin, a diastereomer of the natural peptidyl nucleoside antibiotic puromycin, has been synthesized from l -xylose in 13 steps.
Carrie L.K. Gilbert, Christopher R. Lisek, Roger L. White, Giuseppe Gumina   +3 more
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Effects of Puromycin on Learning in the Toad

Psychological Reports, 1972
Toads were tested to determine whether puromycin could produce memory blockage of a learned aversion for stinging honeybees. Although the drug disrupted the learned aversion, there was evidence that the noxious consequences of puromycin itself produced a generalized aversion in the feeding situation which interacted with the effects on memory.
H E, Titus, D J, Costanzo
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Stereochemistry of the puromycin reaction

Biochemical and Biophysical Research Communications, 1971
Summary Space-filling models have shown that peptidyl-puromycin cannot be formed if puromycin is displacing the end of aminoacyl-tRNA. Instead, the models show that puromycin “hugs” the terminus of peptidyl-tRNA in such a way that the free amino group of the antibiotic is in a perfect position for a nucleophylic attack on the carbonyl carbon of the ...
openaire   +2 more sources

Inhibition of Interferon Action by Puromycin

The Journal of Immunology, 1965
Summary Puromycin, an inhibitor of protein synthesis, also inhibits the anti-viral action of interferon; this does not appear to be due to a block in the adsorption of interferon. The inhibition of interferon action is reversed by prolonged incubation of cells in buffer after removal of interferon and puromycin. When protein synthesis is
R M, Friedman, J A, Sonnabend
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Puromycin: Action on Neuronal Mitochondria

Science, 1968
Puromycin, in dosages that inhibit cerebral protein synthesis and expression of memory in mice, produces swelling of neuronal mitochondria. Acetoxycycloheximide, which inhibits cerebral protein synthesis to the same extent as puromycin, fails to produce swelling of neuronal mitochondria.
P, Gambetti, N K, Gonatas, L B, Flexner
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Puromycin analogs. Effect of aryl-substituted puromycin analogs on the ribosomal peptidyltransferase reaction

Journal of Medicinal Chemistry, 1981
A series of ortho- and para-substituted L-phenylalanylpuromycin analogues were synthesized and evaluated as substrates for the peptidyltransferase reaction of Escherichia coli ribosomes. Kinetic results reveal that substitution of the p-methoxy group of the puromycin molecule alters the peptidyltransferase activity of the molecule with the following ...
H, Lee, K L, Fong, R, Vince
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Metabolism of puromycin by yeast cells

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract Yeast cells, supplied with high concentrations of puromycin, formed acyl aminoacyl puromycins and aminoacyl puromycins. These compounds were identified by their behaviour in chromatography and electrophoresis, by the incorporation of radioactive amino acids, acetate, and formate, and by reaction with 1-dimethylamino naphthalene-5-sulfonyl ...
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The Puromycin-Sensitive Aminopeptidase

2004
The puromycin-sensitive aminopeptidase (ApPS) was identified as the major enkephalin-degrading activity in brain, but has subsequently been implicated in a variety of cellular functions. In addition to regulating the concentration of neuropeptides, ApPS has been suggested to be involved in reproductive function, cell cycle regulation, regulation of ...
Michael W. Thompson, Louis B. Hersh
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Synthesis of a Puromycin Analog

Angewandte Chemie International Edition in English, 1968
F W, Lichtenhaler, H P, Albrecht
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Puromycin and puromycin-tetracycline in amebiasis.

Antibiotic medicine & clinical therapy (New York, NY), 2003
E, ECHEVERRIA ALVAREZ, A, LEON MORENO
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