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Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi.
S. Sukumar, B. Lämmle, S. Cataland
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ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function
Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome (ANDS), a rare genetic disease characterized by autism spectrum disorder (ASD), attention deficit/hyperactivity disorder, and speech and motor deficits.
Chang Hoon Cho+14 more
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How cortical areas interact via feedforward and feedback signaling remains unclear. Here, the authors recorded from V1 and V2/V4 in macaque visual cortex and found that feedforward and feedback interactions vary with stimulus drive and involve different ...
João D. Semedo+7 more
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Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death [PDF]
Purpose Transient global ischemia arising in human due to cardiac arrest causes selective, delayed neuronal death in hippocampal CA1 and cognitive impairment.
Chang Hoon Cho+7 more
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Immune Thrombocytopenic Purpura in a Patient with Covid-19
Immune Thrombocytopenic Purpura and Covid-19 Immune thrombocytopenia with lower-extremity purpura, mucosal bleeding, and cerebral microhemorrhage developed during the clinical course in a 65-year-o...
A. Zulfiqar+3 more
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ISTH guidelines for treatment of thrombotic thrombocytopenic purpura
Despite advances in treatment options for thrombotic thrombocytopenic purpura (TTP), there are still limited high quality data to inform clinicians regarding its appropriate treatment.
X. L. Zheng+13 more
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ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura
Despite an increase in our understandings of pathogenesis of thrombotic thrombocytopenic purpura (TTP), the approaches for initial diagnosis and management of TTP vary significantly.
X. L. Zheng+13 more
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Sensory systems preferentially strengthen responses to stimuli based on their reliability at conveying accurate information. While previous reports demonstrate that the brain reweighs cues based on dynamic changes in reliability, how the brain may learn ...
Keanu Shadron, José Luis Peña
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Neurotransmitter release is a highly controlled process by which synapses can critically regulate information transfer within neural circuits. While presynaptic receptors – typically activated by neurotransmitters and modulated by neuromodulators ...
Pablo J Lituma+4 more
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IgA vasculitis associated with renal and joint findings in children and correlation between patient’s compliance in treatment: A case series [PDF]
Objectives. Evaluation and therapeutic management of pediatric patients having Henoch-Schönlein purpura with renal and joint involvement and the importance of their follow-up in preventing complications.
Ana-Maria Roxana Koller, Alexandra Man
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