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Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management

open access: yesJournal of Clinical Medicine, 2021
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi.
S. Sukumar, B. Lämmle, S. Cataland
semanticscholar   +1 more source

ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function

open access: yesNature Communications, 2023
Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome (ANDS), a rare genetic disease characterized by autism spectrum disorder (ASD), attention deficit/hyperactivity disorder, and speech and motor deficits.
Chang Hoon Cho   +14 more
doaj   +1 more source

Feedforward and feedback interactions between visual cortical areas use different population activity patterns

open access: yesNature Communications, 2022
How cortical areas interact via feedforward and feedback signaling remains unclear. Here, the authors recorded from V1 and V2/V4 in macaque visual cortex and found that feedforward and feedback interactions vary with stimulus drive and involve different ...
João D. Semedo   +7 more
doaj   +1 more source

Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death [PDF]

open access: yesInternational Neurourology Journal, 2019
Purpose Transient global ischemia arising in human due to cardiac arrest causes selective, delayed neuronal death in hippocampal CA1 and cognitive impairment.
Chang Hoon Cho   +7 more
doaj   +1 more source

Immune Thrombocytopenic Purpura in a Patient with Covid-19

open access: yesNew England Journal of Medicine, 2020
Immune Thrombocytopenic Purpura and Covid-19 Immune thrombocytopenia with lower-extremity purpura, mucosal bleeding, and cerebral microhemorrhage developed during the clinical course in a 65-year-o...
A. Zulfiqar   +3 more
semanticscholar   +1 more source

ISTH guidelines for treatment of thrombotic thrombocytopenic purpura

open access: yesJournal of Thrombosis and Haemostasis, 2020
Despite advances in treatment options for thrombotic thrombocytopenic purpura (TTP), there are still limited high quality data to inform clinicians regarding its appropriate treatment.
X. L. Zheng   +13 more
semanticscholar   +1 more source

ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura

open access: yesJournal of Thrombosis and Haemostasis, 2020
Despite an increase in our understandings of pathogenesis of thrombotic thrombocytopenic purpura (TTP), the approaches for initial diagnosis and management of TTP vary significantly.
X. L. Zheng   +13 more
semanticscholar   +1 more source

Development of frequency tuning shaped by spatial cue reliability in the barn owl’s auditory midbrain

open access: yeseLife, 2023
Sensory systems preferentially strengthen responses to stimuli based on their reliability at conveying accurate information. While previous reports demonstrate that the brain reweighs cues based on dynamic changes in reliability, how the brain may learn ...
Keanu Shadron, José Luis Peña
doaj   +1 more source

Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

open access: yeseLife, 2021
Neurotransmitter release is a highly controlled process by which synapses can critically regulate information transfer within neural circuits. While presynaptic receptors – typically activated by neurotransmitters and modulated by neuromodulators ...
Pablo J Lituma   +4 more
doaj   +1 more source

IgA vasculitis associated with renal and joint findings in children and correlation between patient’s compliance in treatment: A case series [PDF]

open access: yesRomanian Journal of Pediatrics, 2023
Objectives. Evaluation and therapeutic management of pediatric patients having Henoch-Schönlein purpura with renal and joint involvement and the importance of their follow-up in preventing complications.
Ana-Maria Roxana Koller, Alexandra Man
doaj   +1 more source

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