Results 71 to 80 of about 78,453 (209)

Wiskott–Aldrich syndrome that was initially diagnosed as immune thrombocytopenic purpura secondary to a cytomegalovirus infection

SAGE Open Medical Case Reports, 2018
Wiskott–Aldrich syndrome is a rare X-linked recessive disease resulting from variations in the WAS gene. Wiskott–Aldrich syndrome is sometimes difficult to differentiate from immune thrombocytopenic purpura. A 2-month-old boy was admitted to our hospital
Ryota Kaneko, Shohei Yamamoto, Naoko Okamoto, Kosuke Akiyama, Ryosuke Matsuno, Daisuke Toyama, Akihiro Hoshino, Kohsuke Imai, Keiichi Isoyama   +8 more
doaj   +1 more source

Utility and Safety of Romiplostim as an Alternative to Platelet Transfusion for Neonates

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Thrombocytopenia is a common challenge in the neonatal intensive care unit, traditionally managed with platelet transfusions. However, transfusions are associated with significant risks, including increased mortality and neurodevelopmental impairment.
Rachel N. Zeno, Sara Awad, Harry Lesmana
wiley   +1 more source

Long-term Kidney Outcomes in Patients With Acquired Thrombotic Thrombocytopenic Purpura

Kidney International Reports, 2017
Severe acute kidney injury (AKI) and chronic kidney disease (CKD) are considered to be uncommon in patients with acquired thrombotic thrombocytopenic purpura.
Dustin J. Little, Lauren M. Mathias, Evaren E. Page, Johanna A. Kremer Hovinga, Sara K. Vesely, James N. George   +5 more
doaj   +1 more source

Target‐Mediated Drug Disposition (TMDD) Revisited: High Versus Low‐Affinity Approximations of the TMDD Model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 7, Page 1262-1272, July 2025.
ABSTRACT Target‐mediated drug disposition (TMDD) is often associated with high‐affinity binding to a target resulting in nonlinear pharmacokinetics. For large molecules, such as monoclonal antibodies, this can lead to increased clearance at sub‐saturating concentrations.
Ronny Straube
wiley   +1 more source

Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2017
Essentials Acquired thrombotic thrombocytopenic purpura (aTTP) is linked with significant morbidity/mortality. Caplacizumab's effect on major thromboembolic (TE) events, exacerbations and death was studied. Fewer caplacizumab‐treated patients had a major
F. Peyvandi, M. Scully, J. A. Hovinga, P. Knöbl, S. Cataland, K. D. Beuf, F. Callewaert, H. Winter, R. Zeldin   +8 more
semanticscholar   +1 more source

Ventilation/perfusion SPECT in children: Feasibility, impact on clinical decision‐making and interrater agreement

Clinical Physiology and Functional Imaging, Volume 45, Issue 4, July 2025.
Abstract Introduction It remains to be established whether it provides any clinical or diagnostic benefits to perform ventilation/perfusion (V/Q) scintigraphy as a single photon emission computed tomography in children. Here, we report our experience with this modality, evaluate its impact on clinical decision‐making and assess its interrater agreement.
Lise Borgwardt, Mette Louise Mørk, Henrik Gutte, Anne Kiil Berthelsen, Robin de Nijs, Ronan M. G. Berg, Jann Mortensen   +6 more
wiley   +1 more source

NEONATAL THROMBOCYTOPENIC PURPURA: REPORT OF TWO CASES AND REVIEW OF LITERATURE [PDF]

Kanem Journal of Medical Sciences, 2018
Introduction: Severe neonatal thrombocytopenia is a hematological emergency that can be due to increased platelet destruction (such as immune-mediated and peripheral platelet consumption) or congenital failure of platelet production.
Abiodun MT, Badejoko B, Oluwafemi RO
doaj  

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

Haematologica, 2008
Background From 20 to 50% of patients who survive an acute episode of the acquired form of thrombotic thrombocytopenic purpura relapse but clinical and laboratory markers of recurrence are not well established.Design and Methods In 109 patients enrolled ...
Flora Peyvandi, Silvia Lavoretano, Roberta Palla, Hendrik B. Feys, Karen Vanhoorelbeke, Tullia Battaglioli, Carla Valsecchi, Maria Teresa Canciani, Fabrizio Fabris, Samo Zver, Marienn Réti, Danijela Mikovic, Mehran Karimi, Gaetano Giuffrida, Luca Laurenti, Pier Mannuccio Mannucci   +15 more
doaj   +1 more source

Rituximab reduces risk for relapse in patients with thrombotic thrombocytopenic purpura.

Blood, 2016
Publisher's Note: There is an [Inside Blood Commentary][1] on this article in this issue. To the editor: Recent systematic reviews assessing the role of rituximab in the management of patients with acquired thrombotic thrombocytopenic purpura (TTP)[1 ...
E. E. Page, J. K. Kremer Hovinga, Deirdra R. Terrell, S. Vesely, J. George   +4 more
semanticscholar   +1 more source

Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

Haematologica, 2011
Background The majority of patients diagnosed with thrombotic thrombocytopenic purpura have autoantibodies directed towards the spacer domain of ADAMTS13.Design and Methods In this study we explored the epitope specificity and immunoglobulin class and ...
Wouter Pos, Nicoletta Sorvillo, Rob Fijnheer, Hendrik B. Feys, Paul H.P Kaijen, Gestur Vidarsson, Jan Voorberg   +6 more
doaj   +1 more source