Results 11 to 20 of about 36,176 (202)

Can COVID-19 Lead to Refractory Thrombotic Thrombocytopenic Purpura (TTP) During Pregnancy and Postpartum? A Case Report and a Review of the Literature. [PDF]

Clin Case Rep
ABSTRACT Thrombotic thrombocytopenic purpura (TTP) is a rare but fatal blood disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multi‐organ dysfunction. This condition often worsens during pregnancy and the postpartum period due to physiological changes.
Shabani A, Razi-Khosroshahi M, Rahmani Seraji H, Faghih N, Hooshyar M.   +4 more
europepmc   +2 more sources

A British Society for Haematology Guideline: Diagnosis and management of thrombotic thrombocytopenic purpura and thrombotic microangiopathies

British Journal of Haematology, 2023
The objective of this guideline is to provide healthcare professionals with clear, up‐to‐date and practical guidance on the management of thrombotic thrombocytopenic purpura (TTP) and related thrombotic microangiopathies (TMAs), including complement ...
M. Scully, R. Rayment, A. Clark, J. Westwood, T. Cranfield, R. Gooding, C. Bagot, A. Taylor, V. Sankar, D. Gale, T. Dutt, J. McIntyre, W. Lester   +12 more
semanticscholar   +1 more source

Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management

Journal of Clinical Medicine, 2021
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi.
S. Sukumar, B. Lämmle, S. Cataland
semanticscholar   +1 more source

Thrombotic Thrombocytopenic Purpura After Ad6.COV2.S Vaccination

Cureus, 2022
Thrombotic thrombocytopenic purpura (TTP) is caused by the deficiency of ADAMTS13, a von Willebrand factor cleaving protease, which results in thrombotic microangiopathy.
S. Ramanan, H. Singh, P. Menon, Parth M Patel, VR Parmar, Devin Malik   +5 more
semanticscholar   +1 more source

Recombinant ADAMTS13 for Hereditary Thrombotic Thrombocytopenic Purpura.

New England Journal of Medicine, 2022
A 27-year-old patient with a history of severe obstetrical complications and arterial thrombosis received a diagnosis of hereditary thrombotic thrombocytopenic purpura (TTP) due to severe ADAMTS13 deficiency when she presented with an acute episode in ...
L. Asmis, A. Serra, A. Krafft, A. Licht, E. Leisinger, J. Henschkowski-Serra, M. Ganter, S. Hauptmann, M. Tinguely, J. K. Kremer Hovinga   +9 more
semanticscholar   +1 more source

Caplacizumab prevents refractoriness and mortality in acquired thrombotic thrombocytopenic purpura: integrated analysis.

Blood Advances, 2021
The efficacy and safety of caplacizumab in individuals with acquired thrombotic thrombocytopenic purpura (aTTP) have been established in the phase 2 TITAN and phase 3 HERCULES trials. Integrated analysis of data from both trials was conducted to increase
F. Peyvandi, S. Cataland, M. Scully, P. Coppo, P. Knoebl, J. K. Kremer Hovinga, A. Metjian, J. de la Rubia, K. Pavenski, Jessica Minkue Mi Edou, H. de Winter, F. Callewaert   +11 more
semanticscholar   +1 more source

Annual Incidence and Severity of Acute Episodes in Hereditary Thrombotic Thrombocytopenic Purpura.

Blood, 2021
Hereditary thrombotic thrombocytopenic purpura (hTTP) is a rare thrombotic microangiopathy characterized by severe congenital ADAMTS13 deficiency and recurring acute episodes causing morbidity and premature death.
E. Tarasco, Lukas Bütikofer, K. Friedman, J. George, I. Hrachovinova, P. Knöbl, M. Matsumoto, A. von Krogh, I. Aebi-Huber, Z. Cermakova, Magdalena Górska-Kosicka, K. Jalowiec, C. Largiadèr, Z. Prohászka, G. Sinkovits, J. Windyga, B. Lämmle, J. K. Kremer Hovinga   +17 more
semanticscholar   +1 more source

Thrombotic thrombocytopenic purpura: a new menace after COVID bnt162b2 vaccine

International journal of hematology, 2021
Thrombotic thrombocytopenic purpura (TTP) is a known menace in hematology and is quite rare in practice with known triggers. Lately, in the COVID-19 pandemic, hematology has seen a new pathology amongst which TTP associated with COVID-19 messenger RNA ...
S. H. Waqar, A. Khan, S. Memon
semanticscholar   +1 more source

ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2020
Despite an increase in our understandings of pathogenesis of thrombotic thrombocytopenic purpura (TTP), the approaches for initial diagnosis and management of TTP vary significantly.
X. L. Zheng, S. Vesely, S. Cataland, P. Coppo, B. Geldziler, A. Iorio, M. Matsumoto, R. Mustafa, M. Pai, G. Rock, L. Russell, R. Tarawneh, J. Valdes, F. Peyvandi   +13 more
semanticscholar   +1 more source

ISTH guidelines for treatment of thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2020
Despite advances in treatment options for thrombotic thrombocytopenic purpura (TTP), there are still limited high quality data to inform clinicians regarding its appropriate treatment.
X. L. Zheng, S. Vesely, S. Cataland, P. Coppo, B. Geldziler, A. Iorio, M. Matsumoto, R. Mustafa, M. Pai, G. Rock, L. Russell, R. Tarawneh, J. Valdes, F. Peyvandi   +13 more
semanticscholar   +1 more source