Results 51 to 60 of about 25,607 (238)

Collaborative Control of UAV Swarms for Target Capture Based on Intelligent Control Theory

Mathematics
Real-time dynamic capture of a single moving target is one of the most crucial and representative tasks in UAV capture problems. This paper proposes a multi-UAV real-time dynamic capture strategy based on a differential game model to address this ...
Yuan Chi, Yijie Dong, Lei Zhang, Zhenyue Qiu, Xiaoyuan Zheng, Zequn Li   +5 more
doaj   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Active Target Defense Differential Game with a Fast Defender

, 2015
This paper addresses the active target defense differential game where an Attacker missile pursues a Target aircraft. A Defender missile is fired by the Target's wingman in order to intercept the Attacker before it reaches the aircraft.
Casbeer, David W., Garcia, Eloy, Pachter, Meir   +2 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

A Deep Reinforcement Learning-Based Intelligent Maneuvering Strategy for the High-Speed UAV Pursuit-Evasion Game

Drones
Given the rapid advancements in kinetic pursuit technology, this paper introduces an innovative maneuvering strategy, denoted as LSRC-TD3, which integrates line-of-sight (LOS) angle rate correction with deep reinforcement learning (DRL) for high-speed ...
Tian Yan, Can Liu, Mengjing Gao, Zijian Jiang, Tong Li   +4 more
doaj   +1 more source

Pursuit Evasion: The Herding Noncooperative Dynamic Game-The Stochastic Model

, 2001
This article proposes a solution to the herding problem, a class of pursuit evasion problem in a stochastic framework. The problem involves a pursuer agent trying to herd a stochastically moving evader agent into a pen. The problem is stated in terms
Kachroo, Pushkin, Shedied, Samy A., Vanlandingham, H.   +2 more
core   +2 more sources

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Orbital Pursuit–Evasion–Defense Linear-Quadratic Differential Game

Aerospace
To find superior guidance strategies for preventing possible interception threats from space debris, out-of-control satellites, etc., this paper investigates an orbital pursuit–evasion–defense game problem with three players called the pursuer, the ...
Zhen-Yu Li
doaj   +1 more source

Decomposition of Differential Games [PDF]

, 2014
This paper provides a decomposition technique for the purpose of simplifying the solution of certain zero-sum differential games. The games considered terminate when the state reaches a target, which can be expressed as the union of a collection of ...
Festa, Adriano, Vinter, Richard
core