Results 181 to 190 of about 444 (217)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

The molecular prognostic score, a classifier for risk stratification of high-grade serous ovarian cancer. [PDF]

J Ovarian Res
Sarkar S, Saha SA, Swarnakar A, Chakrabarty A, Dey A, Sarkar P, Banerjee S, Mitra P.   +7 more
europepmc   +1 more source

The Voice Disrupted: Articulation, Hesitation, and Moral Seriousness in F. R. Leavis's Pedagogy

Critical Quarterly, EarlyView.
Steven Cranfield
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Targeting autophagy can synergize the efficacy of immune checkpoint inhibitors against therapeutic resistance: New promising strategy to reinvigorate cancer therapy. [PDF]

Heliyon
Hashemi M, Mohandesi Khosroshahi E, Tanha M, Khoushab S, Bizhanpour A, Azizi F, Mohammadzadeh M, Matinahmadi A, Khazaei Koohpar Z, Asadi S, Taheri H, Khorrami R, Ramezani Farani M, Rashidi M, Rezaei M, Fattah E, Taheriazam A, Entezari M.   +17 more
europepmc   +1 more source

Literary Journalism on Trial: Janet Malcolm, Criminal Character and the Legacy of New Journalism

Critical Quarterly, EarlyView.
Jess Cotton
wiley   +1 more source

Enchanting the Otherwise: Magical Realism and the Gendered Ontologies of Organizational Becoming

Gender, Work &Organization, EarlyView.
ABSTRACT This paper enacts a feminist‐posthumanist reimagining of gender as ontological disturbance, using magical realism not as metaphor but as epistemological method. Rejecting representational logics and the managerial rationalities of organizational realism, we advance gender not as identity or role but as spectral interference—a transversal ...
Max Ganzin, Diana Ivanycheva
wiley   +1 more source

UNWARRANTED CONFIDENCE: A CRITICAL REVIEW OF THE POVERTY OF ANTI‐REALISM

History and Theory, EarlyView.
ABSTRACT The Poverty of Anti‐Realism: Critical Perspectives on Postmodernist Philosophy of History, edited by Tor Egil Førland and Branko Mitrović, celebrates the new dawn of historical realism, which it claims supersedes the erroneous and harmful anti‐realism.
Jouni‐Matti Kuukkanen
wiley   +1 more source

Architect of the Image: Argumentation, Economy and Translation in Gregory of Nyssa’s On the Human Image

International Journal of Systematic Theology, EarlyView.
Abstract In this contribution to a book symposium on Gregory of Nyssa’s On the Human Image, Morwenna Ludlow reflects on John Behr’s attention to the literary structure and argumentative flow of the book, its interplay with the similarly structured Timaeus of Plato and the difficulties of translating a work of such rhetorical and pastoral sophistication
Morwenna Ludlow
wiley   +1 more source