Results 41 to 50 of about 15,633,684 (298)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Nanomaterial-Enhanced Sizings: Design and Optimisation of a Pilot-Scale Fibre Sizing Line
FibersThis study focuses on the development of a pilot-scale sizing line, including its initial design and installation, operational phases, and optimization of key process parameters.
Dionisis Semitekolos +6 more
doaj +1 more source
, 2021 This is a sample submission generated by Vireo to test the repository deposit features.Test ...
Submitter, Test
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Behaviour and Strength of Headed Shear Stud Connectors
Communications, 2013 Headed stud shear connectors are commonly used to transfer longitudinal shear forces across the steel-concrete interface in composite structures. This paper is focused on the experimental and numerical study on the behaviour of this type of connectors ...
Patricia Duratna +3 more
doaj +1 more source
Shear Behavior of Superposed Perfobond Connectors Considering Lateral Constraints
Applied Sciences, 2022 Superposed perfobond connectors are a type of connector used in composite structures. When the construction conditions are limited to increase the diameter of the opening, the shear capacity of the connector can be improved by enhancing the confining ...
Jiangran Guo +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Comparison of different fiber post systems using push-out bond strength test
Erbil Dental Journal, 2019 Background and Objective: Nowadays, the use of fiber post in weak teeth that had root canal treatment has gained acceptance worldwide. New materials and shapes of fiber posts were introduced.
Hani M. Mouafaq, Shakhawan K. Kadir
doaj