Results 41 to 50 of about 1,501 (112)

Cells of the human respiratory tract support the replication of pathogenic Old World orthohantavirus Puumala

Virology Journal, 2021
Background Transmission of all known pathogenic orthohantaviruses (family Hantaviridae) usually occurs via inhalation of aerosols contaminated with viral particles derived from infected rodents and organ manifestation of infections is characterized by ...
Stefan Hägele, Christian Nusshag, Alexander Müller, Alexandra Baumann, Martin Zeier, Ellen Krautkrämer   +5 more
doaj   +1 more source

Use of a diagnostic Puumala virus real-time RT-PCR in an orthohantavirus endemic region in the Netherlands

Microbiology Spectrum
Laboratory diagnosis of orthohantavirus infection is primarily based on serology. However, for a confirmed serological diagnosis, evaluation of a follow-up serum sample is essential, which is time consuming and causes delay.
Felix Geeraedts, Mariska Wevers, Froukje Bosma, Maria de Boer, J. N. Brinkman, Corine Delsing, Corine GeurtsvanKessel, Barry Rockx, Adri van der Zanden, Gozewijn D. Laverman   +9 more
doaj   +1 more source

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source

Analysis of the relationship between replication of the Hokkaido genotype of Puumala orthohantavirus and autophagy

Virus Research, 2022
Hantaviruses are potentially fatal zoonotic pathogens of the family Hantaviridae. No human infection by the Hokkaido genotype of Puumala orthohantavirus (PUUV-Hok) has been reported.
Kazuma Tamiya, Shintaro Kobayashi, Kentaro Yoshii, Hiroaki Kariwa   +3 more
doaj   +1 more source

Temporal Dynamics of Viremia in Hemorrhagic Fever With Renal Syndrome Patients

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The pathogenesis of hemorrhagic fever with renal syndrome (HFRS) remains incompletely understood. Currently, the clinical diagnosis of HFRS primarily relies on epidemiological history and clinical presentation, while the confirmation of HFRS depends mainly on the detection of hemorrhagic fever antibodies.
ShuWei Ma, JiaYi Zhan, Chao Fan, XuYang Zheng, Hong Du, LiMei Wang, Hong Jiang   +6 more
wiley   +1 more source

Puumala and Tula Virus Differ in Replication Kinetics and Innate Immune Stimulation in Human Endothelial Cells and Macrophages

Viruses, 2019
Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS.
Daniel Bourquain, Clemens Bodenstein, Stefanie Schürer, Lars Schaade   +3 more
doaj   +1 more source

The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts

Frontiers in Microbiology, 2023
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease.
Lineke Begeman, Debby van Riel, Marion P. G. Koopmans, Marion P. G. Koopmans, Thijs Kuiken   +4 more
doaj   +1 more source

Community Assembly Reveals How Environmental Controls Over Rodent Competition Drive Deer Mouse Density and Hantavirus Infection

Ecology Letters, Volume 29, Issue 4, April 2026.
We examined how community assembly processes shape Sin Nombre hantavirus (SNV) dynamics in rodent communities across the southwestern United States. Environmental factors structured community composition, which regulated deer mouse abundance and SNV infection, rather than diversity alone.
Angela D. Luis, Dean E. Pearson
wiley   +1 more source

Surveillance of Zoonotic Pathogens in Small Mammals Across Forests With Different Levels of Anthropization in Eastern France

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The emergence of infectious diseases associated with land‐use changes is well‐documented. However, the presence and dynamics of zoonotic pathogens in small mammals within European forests, whether from rural development or urban greening, remain underexplored.
Marie Bouilloud, Maxime Galan, Anaïs Bordes, Caroline Tatard, Philippe Gauthier, Julien Pradel, Guillaume Castel, Hussein Alburkat, Lara Dutra, Tarja Sironen, Clémence Galon, Sara Moutailler, Zorée Djelouadji, Benjamin Roche, Nathalie Charbonnel, Javier Millán   +15 more
wiley   +1 more source

Molecular Evolution and Zoonotic Potential of Muju Virus (Orthohantavirus puumalaense) in Craseomys regulus, Republic of Korea

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT Orthohantavirus puumalaense causes hemorrhagic fever with renal syndrome in Europe, with Puumala virus (PUUV) as its primary representative. Muju virus (MUJV), harbored by Craseomys regulus, an Arvicolinae rodent species endemic to the Republic of Korea (ROK), is also a genotype of O. puumalaense.
Kyungmin Park, Seong‐Gyu Kim, Jeong‐Ah Kim, Sara P. Prayitno, Jongwoo Kim, Seung‐Ho Lee, Jaeyeon Lee, Ye‐rin Seo, Augustine Natasha, Hee Il Lee, Kisoon Kim, Won‐Keun Kim, Jin‐Won Song   +12 more
wiley   +1 more source