Results 91 to 100 of about 5,652 (231)

The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts

Frontiers in Microbiology, 2023
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease.
Lineke Begeman, Debby van Riel, Marion P. G. Koopmans, Marion P. G. Koopmans, Thijs Kuiken   +4 more
doaj   +1 more source

Dendritic Cells (DCs) as "Fire Accelerants" of Hantaviral Pathogenesis [PDF]

, 2019
Hantaviruses are widespread zoonotic pathogens found around the globe. Depending on their geographical location, hantaviruses can cause two human syndromes, haemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS).
Raftery, Martin J., Schönrich, Günther
core   +1 more source

Antibody feedback regulation

Immunological Reviews, Volume 328, Issue 1, Page 126-142, November 2024.
Summary Antibodies are able to up‐ or downregulate antibody responses to the antigen they bind. Two major mechanisms can be distinguished. Suppression is most likely caused by epitope masking and can be induced by all isotypes tested (IgG1, IgG2a, IgG2b, IgG3, IgM, and IgE).
Birgitta Heyman
wiley   +1 more source

Analytical Performance of the RIDASCREEN^® Hantavirus Puumala IgG/IgM ELISA Assay

Viruses, 2020
The National Reference Center for Hantavirus in Belgium is currently using the Hantavirus IgM/IgG ELISA Progen kit (Heidelberg, Germany) for the detection of the most prevalent Hantavirus in Western Europe, Puumala virus (PUUV).
Melissa Depypere, Katrien Lagrou, Marjan Van Esbroeck, Els Houben, Marc Van Ranst   +4 more
doaj   +1 more source

In silico design and evaluation of a multiepitope vaccine targeting the nucleoprotein of Puumala orthohantavirus

Proteins: Structure, Function, and Bioinformatics, Volume 92, Issue 10, Page 1161-1176, October 2024.
Abstract The Puumala orthohantavirus is present in the body of the bank vole (Myodes glareolus). Humans infected with this virus may develop hemorrhagic fever accompanying renal syndrome. In addition, the infection may further lead to the failure of an immune system completely.
Kunal Bhattacharya, Nongmaithem Randhoni Chanu, Saurav Kumar Jha, Pukar Khanal, Keshav Raj Paudel   +4 more
wiley   +1 more source

Accumulation of point mutations and reassortment of genomic RNA segments are involved in the microevolution of Puumala hantavirus in a bank vole (Myodes glareolus) population [PDF]

, 2008
Razzauti M, Plyusnina A, Henttonen H, Plyusnin A. Accumulation of point mutations and reassortment of genomic RNA segments are involved in the microevolution of Puumala hantavirus in a bank vole (Myodes glareolus) population. J Gen Virol.
Alexander Plyusnin, Angelina Plyusnina, Asikainen, Bernshtein, Brummer-Korvenkontio, Brummer-Korvenkontio, Chare, Crawley, Deyde, Felsenstein, Gavrilovskaya, Hall, Hamano, Heikki Henttonen, Henderson, Huelsenbeck, Hörling, Kallio, Kallio, Kallio, Kimura, Li, Maria Razzauti, Meyer, Mitchell-Jones, Nichol, Niklasson, Novella, Olsson, Plyusnin, Plyusnin, Plyusnin, Plyusnin, Plyusnin, Plyusnin, Plyusnin, Plyusnina, Sall, Sauvage, Schmaljohn, Schmaljohn, Sibold, Sironen, Sironen, Urquidi, Vapalahti, Wilson   +46 more
core   +1 more source

Distribution and genetic heterogeneity of Puumala virus in Sweden

Journal of General Virology, 1996
Small mammals trapped in Sweden were analysed for specific antibody responses against three hantavirus serotypes and for the presence of viral antigen. To determine the genetic identity of viral RNA in lungs of seropositive bank voles (Clethrionomys glareolus), polymerase chain reactions and subsequent partial sequencing of both the M and S segments ...
J, Hörling, A, Lundkvist, M, Jaarola, A, Plyusnin, H, Tegelström, K, Persson, H, Lehväslaiho, B, Hörnfeldt, A, Vaheri, B, Niklasson   +9 more
openaire   +2 more sources

Unveiling the impacts of land use on the phylogeography of zoonotic New World Hantaviruses

Ecography, Volume 2024, Issue 10, October 2024.
Billions of genomic sequences and records of species occurrence are available in public repositories (e.g. National Center for Biotechnology Information, NCBI and the Global Biodiversity Information Facility, GBIF). By implementing analytical tools from different scientific disciplines, data mining these databases can aid in the global surveillance of ...
Gabriel E. García‐Peña, André V. Rubio   +1 more
wiley   +1 more source

Human and rodent humoral immune responses to Andes virus structural proteins [PDF]

, 2005
In the present work we identified B-cell epitopes recognized by sera of humans and rodents naturally infected with Andes virus, a hantavirus present in Chile and Argentina.
Tischler, Nicole D., Galeno, Héctor, Rosemblatt, Mario, Valenzuela, Pablo D.T.   +3 more
core   +1 more source

Puumala Virus Infections in Finland: Increased Occupational Risk for Farmers [PDF]

American Journal of Epidemiology, 1999
Puumala hantavirus, transmitted by bank voles (Clethrionomys glareolus), causes a mild-type hemorrhagic fever with renal syndrome. The disease is common in Finland and is considered an occupational hazard for farmers, but the actual risk has not been assessed by analytical studies.
K, Vapalahti, M, Paunio, M, Brummer-Korvenkontio, A, Vaheri, O, Vapalahti   +4 more
openaire   +2 more sources