Results 71 to 80 of about 3,246 (184)

Puumala and Tula Virus Differ in Replication Kinetics and Innate Immune Stimulation in Human Endothelial Cells and Macrophages

Viruses, 2019
Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS.
Daniel Bourquain, Clemens Bodenstein, Stefanie Schürer, Lars Schaade   +3 more
doaj   +1 more source

Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. [PDF]

PLoS ONE, 2018
BACKGROUND:Information on the sequential appearance, duration, and magnitude of clinical and laboratory parameters in hemorrhagic fever with renal syndrome (HFRS) is limited.
Emil Pal, Miša Korva, Katarina Resman Rus, Nataša Kejžar, Petra Bogovič, Anica Kurent, Tatjana Avšič-Županc, Franc Strle   +7 more
doaj   +1 more source

Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis

Frontiers in Medicine, 2022
Hemophagocytic lymphohistiocytosis may occur in patients with genetic predisposition and in sporadic cases due to malignancy or infection. We describe a 49-year old man with hemorrhagic fever, type 1 respiratory insufficiency and acute kidney injury ...
Maarten A. J. De Smet, Simon Bogaert, Alexander Schauwvlieghe, Amélie Dendooven, Pieter Depuydt, Patrick Druwé   +5 more
doaj   +1 more source

Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Shuang Lu, Shuliang Chen, Yuqing Zhang, Xiaoli Mou, Mingyang Li, Shaowei Zhu, Xingyuan Chen, Tomas M. Strandin, Yale Jiang, Zhoufu Xiang, Yuanyuan Liu, Hairong Xiong, Deyin Guo, Liangjun Chen, Yirong Li, Wei Hou, Fan Luo   +16 more
wiley   +1 more source

The B cell response towards Puumala virus infection : can B cells be infected?

, 2017
Hantavirus infections are rodent-borne viruses causing potential lethal infections in humans. Different hantaviruses exist worldwide, reporting a fatality rate of up to 40%. The Puumala hantavirus (PUUV) is endemic in northern Sweden.
Ahlm, Clas,, Forsell, Mattias,, Wigren, Julia,, Tuiskunen-Bäck, Anne,, Kerkman, Priscilla,, Dernstedt, Andy,   +5 more
core   +1 more source

Hantavirus infection-induced B cell activation elevates free light chains levels in circulation.

PLoS Pathogens, 2021
In humans, orthohantaviruses can cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). An earlier study reported that acute Andes virus HPS caused a massive and transient elevation in the number of circulating ...
Jussi Hepojoki, Luz E Cabrera, Satu Hepojoki, Carla Bellomo, Lauri Kareinen, Leif C Andersson, Antti Vaheri, Satu Mäkelä, Jukka Mustonen, Olli Vapalahti, Valeria Martinez, Tomas Strandin   +11 more
doaj   +1 more source

Reduction in mucosal‐associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN‐γ concentration

European Journal of Immunology, Volume 54, Issue 12, December 2024.
We found a reduced frequency of circulating mucosal‐associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL‐18, and IFN‐γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease.
Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I. Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen   +9 more
wiley   +1 more source

Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein [PDF]

, 2011
Puumala virus (PUUV) is the predominant hantavirus species in Germany causing large numbers of mild to moderate cases of haemorrhagic fever with renal syndrome (HFRS).
Mertens, Marc, Groschup, Martin H., Ulrich, Rainer G., Dobler, G., Wagner-Wiening, C., Kindler, E., Esser, J., Heckel, G., Pfeffer, M., Wolfel, R., Emmerich, P., Petraityte-Burneikiene, R., Schmidt-Chanasit, J., Zvirbliene, A., Groschup, M.H., Essbauer, S.S., Mertens, M., Ulrich, R.G.   +17 more
core   +1 more source

Analytical Performance of the RIDASCREEN^® Hantavirus Puumala IgG/IgM ELISA Assay

Viruses, 2020
The National Reference Center for Hantavirus in Belgium is currently using the Hantavirus IgM/IgG ELISA Progen kit (Heidelberg, Germany) for the detection of the most prevalent Hantavirus in Western Europe, Puumala virus (PUUV).
Melissa Depypere, Katrien Lagrou, Marjan Van Esbroeck, Els Houben, Marc Van Ranst   +4 more
doaj   +1 more source

Antibody feedback regulation

Immunological Reviews, Volume 328, Issue 1, Page 126-142, November 2024.
Summary Antibodies are able to up‐ or downregulate antibody responses to the antigen they bind. Two major mechanisms can be distinguished. Suppression is most likely caused by epitope masking and can be induced by all isotypes tested (IgG1, IgG2a, IgG2b, IgG3, IgM, and IgE).
Birgitta Heyman
wiley   +1 more source