Results 61 to 70 of about 2,445 (155)

Analytical Performance of the RIDASCREEN^® Hantavirus Puumala IgG/IgM ELISA Assay

Viruses, 2020
The National Reference Center for Hantavirus in Belgium is currently using the Hantavirus IgM/IgG ELISA Progen kit (Heidelberg, Germany) for the detection of the most prevalent Hantavirus in Western Europe, Puumala virus (PUUV).
Melissa Depypere, Katrien Lagrou, Marjan Van Esbroeck, Els Houben, Marc Van Ranst   +4 more
doaj   +1 more source

Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Shuang Lu, Shuliang Chen, Yuqing Zhang, Xiaoli Mou, Mingyang Li, Shaowei Zhu, Xingyuan Chen, Tomas M. Strandin, Yale Jiang, Zhoufu Xiang, Yuanyuan Liu, Hairong Xiong, Deyin Guo, Liangjun Chen, Yirong Li, Wei Hou, Fan Luo   +16 more
wiley   +1 more source

Reduction in mucosal‐associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN‐γ concentration

European Journal of Immunology, Volume 54, Issue 12, December 2024.
We found a reduced frequency of circulating mucosal‐associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL‐18, and IFN‐γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease.
Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I. Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen   +9 more
wiley   +1 more source

Antibody feedback regulation

Immunological Reviews, Volume 328, Issue 1, Page 126-142, November 2024.
Summary Antibodies are able to up‐ or downregulate antibody responses to the antigen they bind. Two major mechanisms can be distinguished. Suppression is most likely caused by epitope masking and can be induced by all isotypes tested (IgG1, IgG2a, IgG2b, IgG3, IgM, and IgE).
Birgitta Heyman
wiley   +1 more source

In silico design and evaluation of a multiepitope vaccine targeting the nucleoprotein of Puumala orthohantavirus

Proteins: Structure, Function, and Bioinformatics, Volume 92, Issue 10, Page 1161-1176, October 2024.
Abstract The Puumala orthohantavirus is present in the body of the bank vole (Myodes glareolus). Humans infected with this virus may develop hemorrhagic fever accompanying renal syndrome. In addition, the infection may further lead to the failure of an immune system completely.
Kunal Bhattacharya, Nongmaithem Randhoni Chanu, Saurav Kumar Jha, Pukar Khanal, Keshav Raj Paudel   +4 more
wiley   +1 more source

Determination of Procalcitonin Levels in Patients with Nephropathia Epidemica - A Useful Tool or an Unnecessary Diagnostic Procedure?

Kidney & Blood Pressure Research, 2015
Background/Aims: Puumala virus causes nephropathia epidemica (NE), a milder form of hemorrhagic fever with renal syndrome that occurs in Central and Northern Europe. Several studies have sought to identify risk factors for severe NE.
Joerg Latus, Daniel Kitterer, Stephan Segerer, Ferruh Artunc, M. Dominik Alscher, Niko Braun   +5 more
doaj   +1 more source

Disease burden of Puumala virus infections, 1995–2008

Epidemiology and Infection, 2010
SUMMARYPuumala virus (PUUV) causes mild haemorrhagic fever with renal syndrome, a rodent-borne zoonosis. To evaluate the disease burden of PUUV infections in Finland, we analysed data reported by laboratories to the National Infectious Disease Registry during 1995–2008 and compared these with data from other national registries (death, 1998–2007 ...
P, Makary, M, Kanerva, J, Ollgren, M J, Virtanen, O, Vapalahti, O, Lyytikäinen   +5 more
openaire   +2 more sources

Unveiling the impacts of land use on the phylogeography of zoonotic New World Hantaviruses

Ecography, Volume 2024, Issue 10, October 2024.
Billions of genomic sequences and records of species occurrence are available in public repositories (e.g. National Center for Biotechnology Information, NCBI and the Global Biodiversity Information Facility, GBIF). By implementing analytical tools from different scientific disciplines, data mining these databases can aid in the global surveillance of ...
Gabriel E. García‐Peña, André V. Rubio   +1 more
wiley   +1 more source

Clinical and etiological characteristics of severe hemorrhagic fever caused by coinfection of hantaan orthohantavirus and severe fever with thrombocytopenia syndrome virus

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) usually have different infection routes, and coinfection is relatively rare. This study examines the clinical and etiological characteristics of coinfection by these two pathogens to provide important references for clinical diagnosis and ...
Feng Jiang, Yongxiang Zhao, Ruihao Peng, Ya Wen, Yudan Bi, Yichen Zhou, Yao Chen, Hua Deng, Xiaohu Han, Zeliang Chen   +9 more
wiley   +1 more source

Citizens envisioning life in 2040: A qualitative corporate foresight study in London

FUTURES &FORESIGHT SCIENCE, Volume 6, Issue 2, June 2024.
Abstract Urban living is changing. Citizens explore new lifestyles in practice and envision alternative urban futures. Companies, as significant stakeholders in cities, are building urban infrastructure and serving citizens' needs. To succeed in the future, companies must be able to navigate the complexity and diversity of evolving cities.
Pauli Komonen, Susanne Jacobson
wiley   +1 more source