Results 61 to 70 of about 5,277 (210)

Susceptibility of human cells to Puumala virus infection

Journal of General Virology, 1993
Nephropathia epidemica involves several organs including kidney, lung, liver and brain. To investigate the susceptibility of putative target cells to the agent responsible, Puumala virus, we screened established human cell lines of lung (WI-38, A-427, CCD-11Lu), kidney (A-704), liver (Hep G2), pharynx (Detroit 562), submaxillary gland (A-253) and ...
M, Temonen, O, Vapalahti, H, Holthöfer, M, Brummer-Korvenkontio, A, Vaheri, H, Lankinen   +5 more
openaire   +2 more sources

Hantavirus in rodents in the United States: Temporal and spatial trends and report of new hosts

Ecosphere, Volume 16, Issue 3, March 2025.
Abstract In North America, the rodent‐borne hantavirus pulmonary syndrome is predominantly caused by the Sin Nombre virus, typically associated with the deer mouse Peromyscus maniculatus. Utilizing data from the National Ecological Observatory Network (NEON) hantavirus program, we assessed factors that may influence the spatial and temporal ...
Francisca Astorga, Abdelghafar Alkishe, Paanwaris Paansri, Gabriel Mantilla, Luis E. Escobar   +4 more
wiley   +1 more source

Phylogenetic analysis of variants of the Puumala virus (Hantaviridae: Orthohantavirus) circulating in the Saratov region

Вопросы вирусологии
The objective is to determine the complete nucleotide sequence and conduct a phylogenetic analysis of genome variants of the Puumala virus isolated in the Saratov region. Materials and methods.
Yaroslav M. Krasnov, Ekaterina V. Naidenova, Natalia P. Guseva, Tatyana A. Polunina, Natalya A. Sharapova, Ekaterina A. Sosedova, Nina V. Kotova, Kirill S. Zakharov, Andrey V. Kazantsev, Irina V. Domanina, Vladimir N. Chekashov, Mikhail M. Shilov, Evgeniy N. Kondratiev, Natalya A. Osina, Vladimir V. Kutyrev   +14 more
doaj   +1 more source

Global dynamics of a stage-structured hantavirus infection model with seasonality

Nonlinear Analysis, 2021
In this paper, we study a time-periodic model, which incorporates seasonality and host stage-structure. This model describes the propagation of Puumala hantavirus within the bank vole population of Clethrionomys glareolus.
Junli Liu, Tailei Zhang
doaj   +1 more source

Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome [PDF]

, 2018
We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS).
Avsic-Zupanc, Tatjana, Bellomo, Carla, Korva, Misa, Martinez, Valeria P., Mustonen, Jukka, Mäkelä, Satu, Papa, Anna, Strandin, Tomas, Vaheri, Antti   +8 more
core   +2 more sources

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Gastrointestinal Tract As Entry Route for Hantavirus Infection [PDF]

, 2017
Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe.
Brocato, Rebecca L., Bücker, Roland, Hooper, Jay W., Jürgensen, Christian, Krüger, Detlev H., Perley, Casey C., Schulzke, Joerg-Dieter, Witkowski, Peter T.   +7 more
core   +2 more sources

Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Shuang Lu, Shuliang Chen, Yuqing Zhang, Xiaoli Mou, Mingyang Li, Shaowei Zhu, Xingyuan Chen, Tomas M. Strandin, Yale Jiang, Zhoufu Xiang, Yuanyuan Liu, Hairong Xiong, Deyin Guo, Liangjun Chen, Yirong Li, Wei Hou, Fan Luo   +16 more
wiley   +1 more source

Natural Focal Viral Fevers in the South of the European Part of Russia. Hemorrhagic Fever with Renal syndrome

Проблемы особо опасных инфекций, 2020
Objective of the study was to determine the modem epizootic and epidemic peculiarities of hemorrhagic fever with renal syndrome in the south of the European part of Russia. Materials and methods.
O. V. Maletskaya, T. V. Taran, D. A. Prislegina, A. E. Platonov, V. M. Dubyansky, A. S. Volynkina, N. F. Vasilenko, Yu. N. Tokhov, N. V. Tsapko   +8 more
doaj   +1 more source

Reduction in mucosal‐associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN‐γ concentration

European Journal of Immunology, Volume 54, Issue 12, December 2024.
We found a reduced frequency of circulating mucosal‐associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL‐18, and IFN‐γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease.
Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I. Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen   +9 more
wiley   +1 more source