Results 61 to 70 of about 2,318 (177)

Reduction in mucosal‐associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN‐γ concentration

open access: yesEuropean Journal of Immunology, Volume 54, Issue 12, December 2024.
We found a reduced frequency of circulating mucosal‐associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL‐18, and IFN‐γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease.
Iivo Hetemäki   +9 more
wiley   +1 more source

Global dynamics of a stage-structured hantavirus infection model with seasonality

open access: yesNonlinear Analysis, 2021
In this paper, we study a time-periodic model, which incorporates seasonality and host stage-structure. This model describes the propagation of Puumala hantavirus within the bank vole population of Clethrionomys glareolus.
Junli Liu, Tailei Zhang
doaj   +1 more source

Antibody feedback regulation

open access: yesImmunological Reviews, Volume 328, Issue 1, Page 126-142, November 2024.
Summary Antibodies are able to up‐ or downregulate antibody responses to the antigen they bind. Two major mechanisms can be distinguished. Suppression is most likely caused by epitope masking and can be induced by all isotypes tested (IgG1, IgG2a, IgG2b, IgG3, IgM, and IgE).
Birgitta Heyman
wiley   +1 more source

Puumala and Tula Virus Differ in Replication Kinetics and Innate Immune Stimulation in Human Endothelial Cells and Macrophages

open access: yesViruses, 2019
Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS.
Daniel Bourquain   +3 more
doaj   +1 more source

In silico design and evaluation of a multiepitope vaccine targeting the nucleoprotein of Puumala orthohantavirus

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 92, Issue 10, Page 1161-1176, October 2024.
Abstract The Puumala orthohantavirus is present in the body of the bank vole (Myodes glareolus). Humans infected with this virus may develop hemorrhagic fever accompanying renal syndrome. In addition, the infection may further lead to the failure of an immune system completely.
Kunal Bhattacharya   +4 more
wiley   +1 more source

Two clinical cases of renal syndrome caused by Dobrava/Saaremaa hantaviruses imported to the Netherlands from Poland and Belarus, 2012–2014 [PDF]

open access: yesInfection Ecology & Epidemiology, 2016
We report the rare event of two imported cases in the Netherlands presenting with renal syndrome caused by Dobrava (DOBV)/Saaremaa (SAAV) hantaviruses.
Corine H. GeurtsvanKessel   +9 more
doaj   +1 more source

Unveiling the impacts of land use on the phylogeography of zoonotic New World Hantaviruses

open access: yesEcography, Volume 2024, Issue 10, October 2024.
Billions of genomic sequences and records of species occurrence are available in public repositories (e.g. National Center for Biotechnology Information, NCBI and the Global Biodiversity Information Facility, GBIF). By implementing analytical tools from different scientific disciplines, data mining these databases can aid in the global surveillance of ...
Gabriel E. García‐Peña   +1 more
wiley   +1 more source

Abstract

open access: yes, 2022
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue S1, October 2022.
wiley   +1 more source

Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. [PDF]

open access: yesPLoS ONE, 2018
BACKGROUND:Information on the sequential appearance, duration, and magnitude of clinical and laboratory parameters in hemorrhagic fever with renal syndrome (HFRS) is limited.
Emil Pal   +7 more
doaj   +1 more source

The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts

open access: yesFrontiers in Microbiology, 2023
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease.
Lineke Begeman   +4 more
doaj   +1 more source

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