TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source
Digital Demodulation Method and Application of a PWM-Excited Differential Self-Inductive Displacement Transducer. [PDF]
Guo H, Shi B, Chen H, Liu B.
europepmc +1 more source
UC2‐ESP: A general‐purpose framework for open‐source microscopy control
Abstract Building the optical setup for investigating biological questions comes with challenges. A major such challenge is setting up and synchronizing the control of multiple hardware components such as stages, cameras and lasers. With UC2‐ESP, we present a low‐cost electronics system powered by the ESP32 microcontroller (∼$10), designed as an ...
Benedict Diederich +5 more
wiley +1 more source
SEMPLR: an R package for transcription factor binding prediction. [PDF]
Kenney GE +4 more
europepmc +1 more source
Pulse Width Modulation (PWM) is widely used in embedded control systems, particularly for servo motor control, where timing precision directly determines positional accuracy. On Raspberry Pi platforms running a general-purpose Linux kernel, PWM signals are commonly generated in software, making edge timing dependent on operating system scheduling. This
Elmquist, Anton +1 more
openaire +1 more source
Neural correlates of pure apathy in multiple sclerosis: An exploratory neuroimaging study
Abstract Pure apathy is relatively common in people with Multiple Sclerosis (PwMS), but its neural mechanisms remain unexplored. Therefore, we investigated the neural correlates of pure apathy in PwMS, differentiating it from depression. Sixty‐two PwMS underwent neuropsychological assessments and Magnetic Resonance Imaging scans.
Valentina Torchia +7 more
wiley +1 more source
ASIC and FPGA based DPWM architectures for single-phase and single-output DC-DC converter: a review
Chander Subhash +2 more
doaj +1 more source
Real-Time Feedback Strategically Regulates Optoelectronics for Customized Optogenetic Spinal Cord Regeneration. [PDF]
Xia K +17 more
europepmc +1 more source
Abstract Prior studies in multiple sclerosis (MS) suggest preserved recognition of positive emotions despite deficits for negative ones, but this dissociation may reflect methodological limitations (valence‐asymmetry: positive‐valence being limited to happiness/joy in basic‐emotion sets). This study tested whether emotion–recognition deficits in MS are
Laurent Zikos +6 more
wiley +1 more source
Application of unsupervised learning to cluster swine breeding herds based on key performance indicators in Southern Brazil. [PDF]
Ulguim RR +10 more
europepmc +1 more source

