Results 91 to 100 of about 1,975 (157)

Application of the Mass Spectrometry–High‐Throughput Technique Over the Immunohistochemical Analysis for Human Brain Tumor Diagnosis and Prognosis: Insights Into Biomarkers' Identification for the Case Study of Grade IV Astrocytomas and Meningiomas

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Human brain tumors were commonly monitored in hospital/clinical laboratories by immunohistochemistry (IHC) technique, which provides major insights into their classification. However, this technique remains laborious and still shows pitfalls. Therefore, the current study was endeavored to reveal the assets of the application of high‐throughput
Kaouthar Louati, Fatma Kolsi, Manel Mellouli, Hanen Louati, Rim Kallel, Rania Zribi, Mahdi Borni, Leila Sellami Hakim, Amina Maalej, Sirine Choura, Mohamed Chamkha, Sami Sayadi, Zouheir Khemakhem, Tahya Sellami Boudawara, Mohamed Zaher Boudawara, Kaouthar Zribi, Fathi Safta   +16 more
wiley   +1 more source

Spatial Transcriptomic Landscape of Canine Oral Squamous Cell Carcinoma

Molecular Carcinogenesis, Volume 64, Issue 9, Page 1415-1428, September 2025.
ABSTRACT Canine oral squamous cell carcinoma (COSCC) is the second most common oral tumor in dogs and the most relevant for comparative human trials as a spontaneous large animal model of disease. Historical genomic work has focused primarily on bulk sequencing.
Stephanie Goldschmidt, Clifford G. Tepper, Jack Goon, Maria Soltero‐Rivera, Robert Rebhun, Andrew C. Birkeland, Xiao‐Jing Wang, Ryan R. Davis, Stephenie Y. Liu, Iris Rivas, Brian Murphy, Natalia Vapniarsky   +11 more
wiley   +1 more source

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

Cell Reports, 2018
Summary: Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation.
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant   +21 more
doaj   +1 more source

PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors

Oncology Letters
Although recombinant human TNF-related apoptosis-inducing ligand (TRAIL) protein exhibits antitumor activity in a number of lung and liver cancer cells and tumor-bearing animals, TRAIL resistance has substantially restricted its clinical application ...
Chengcheng You, Jinlan He, Chunyu Cao, Deqiao Sheng, Lin Wang, Zhi-Hong Huang, Xiaoling Zhang, Chang-Shen Yi, Yingming Sun, Yiling Huang   +9 more
semanticscholar   +1 more source

Identification of novel androgen receptor target genes in prostate cancer

Molecular Cancer, 2007
Background The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression.
Gerald William L, Scher Howard I, Arasheben Armin, Tilley Wayne D, Cogan Jon P, Pregizer Steve, Barski Artem, Jia Li, Prescott Jennifer, Jariwala Unnati, Buchanan Grant, Coetzee Gerhard A, Frenkel Baruch   +12 more
doaj   +1 more source

Kindlin-2 links mechano-environment to proline synthesis and tumor growth

Nature Communications, 2019
The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with ...
Ling Guo, Chunhong Cui, Kuo Zhang, Jiaxin Wang, Yilin Wang, Yixuan Lu, Ka Chen, Jifan Yuan, Guozhi Xiao, Bin Tang, Ying Sun, Chuanyue Wu   +11 more
doaj   +1 more source

PYCR1 is differentially expressed in central nervous system metastasis in human breast cancer.

, 2023
Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer.
openaire   +1 more source

Integrated Bioinformatics Analysis Reveals the Clinical and Epigenetic Significance of PYCR1 as a Diagnostic, Prognostic, and Therapeutic Biomarker in Lung Adenocarcinoma

Asian journal of applied science and technology
Lung adenocarcinoma (LUAD) is still one of the main causes of death from cancers globally; hence, there is a need for developing new biomarkers and targets for diagnosis and treatment.
Md. Mahbubol Alam, Rifah Tamanna Begum, Sumon Ahmed Suvo, Fahamida Binta Anower, Sahariare Nazim, Md. Fardin Islam, Md. Imam Mahdi Ratul   +6 more
semanticscholar   +1 more source

Identification of cell differentiation trajectory-related gene signature to reveal the prognostic significance and immune landscape in prostate cancer based on multiomics analysis

Heliyon
Background: In the context of prostate cancer (PCa), the occurrence of biochemical recurrence (BCR) stands out as a pivotal factor significantly impacting prognosis, potentially leading to metastasis and mortality.
Liangxue Sun, Zhouting Tuo, Xin Chen, Huming Wang, Zhaojie Lyu, Guangyuan Li   +5 more
doaj   +1 more source

PYCR1 promotes glutamine metabolism and the progression of lung adenocarcinoma by regulating the expression of OPLAH.

Clinical and Experimental Medicine (Testo stampato)
Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Glutamine plays a critical role in the progression of LUAD. However, the function of pyrroline-5-carboxylate reductase 1 (PYCR1) and its regulatory role in glutamine metabolism remain ...
Wei Chen, Kai Wang, Renyu Wang, Xufeng Deng, Xiaobing Liu, Peng Dai, Quanxing Liu   +6 more
semanticscholar   +1 more source