Results 131 to 140 of about 1,975 (157)

Epigenetic modification facilitates proline synthase PYCR1 aberrant expression in gastric cancer

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2022
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to the progression of gastric cancer (GC) and indicates poor survival. However, PYCR1 expression profile in GC subtypes and the mechanism behind its upregulation are not well-studied.PYCR1 expression profiles in GC subtypes and different stages of gastric carcinogenesis were assessed ...
Liya Zhou, Shiyu Xiao, Yin Zhihao
exaly   +3 more sources

MiR-328–3p inhibits lung adenocarcinoma-genesis by downregulation PYCR1

Biochemical and Biophysical Research Communications, 2021
A vast majority of patients with NSCLC (non-small cell lung cancer) have lung adenocarcinoma (LA), and the survival rate of LA varies from 5% to 75% depending on the severity of this adenocarcinoma. PYCR1 (abnormal pyrroline-5-carboxylate reductase 1) gene and miR-328-3p have been found to be associated with cancer development.
Jiancong Lu
exaly   +3 more sources

PYCR1 expresses in cancer-associated fibroblasts and accelerates the progression of C6 glioblastoma.

Histology and histopathology
Cancer-associated fibroblasts (CAFs) play important roles in tumor microenvironments. Pyrroline-5-carboxylate reductase 1 (PYCR1) is a potential cancer therapy target. This study aimed to explore the expression of PYCR1 in glioma-associated CAFs and analyze the effects of PYCR1 expression in CAFs on the proliferation of C6 glioma.A rat glioma model was
Mingkun Zhang, Baibin Bi, Guangcun Liu, Xiaoyong Fan   +3 more
semanticscholar   +3 more sources

PYCR1 Promotes Esophageal Squamous Cell Carcinoma by Interacting With EGFR to Affecting the PI3K/Akt/mTOR Signaling Pathway

Journal of Gene Medicine
The expression and functional role of pyrroline‐5‐carboxylate reductase 1 (PYCR1) in esophageal squamous cell carcinoma (ESCC) remain poorly understood. This study aimed to elucidate the role and underlying mechanisms of PYCR1 in ESCC.
Yu-Qi Meng, Hai-Ming Feng, Bin Li, Yuan Xie, Zheng Li, Zhen-Qing Li, Xuan Li   +6 more
semanticscholar   +1 more source

DJ-1 cooperates with PYCR1 in cell protection against oxidative stress

Biochemical and Biophysical Research Communications, 2013
DJ-1, a product of the DJ-1/PARK7 gene, has been suggested to play various functions involved in transcriptional regulation, protease activity, anti-oxidative stress activity, and regulation of mitochondrial complex I. Such a variety of functions of DJ-1 are supposed to be realized through interactions with different partner proteins.
Tatsuki, Yasuda, Yusuke, Kaji, Tomohiro, Agatsuma, Takeshi, Niki, Mitsuhiro, Arisawa, Satoshi, Shuto, Hiroyoshi, Ariga, Sanae M M, Iguchi-Ariga   +7 more
openaire   +2 more sources

The role of Pycr1 in the pathomechanism of autosomal recessive cutis laxa

2014
Cutis laxa is an umbrella term for several disorders having in common lax and wrinkled skin most likely due to rarefaction of elastic fibers in the connective tissues. Autosomal recessive cutis laxa (ARCL) with progeroid features caused by mutations in PYCR1 is mainly characterized by intrauterine growth retardation, connective tissue weakness, reduced ...
openaire   +3 more sources

Abstract 983: Beyond the active site: Discovery of novel PYCR1 allosteric binding sites via structure-oriented fragment crystallographic screening

Cancer Research
Pyrroline-5-carboxylate reductase 1 (PYCR1), a member of the PYCR enzyme family, plays a pivotal role in the proline biosynthesis pathway. Enzymes involved in proline metabolism have been increasingly recognized as key regulators of cancer cell ...
O. Tarkhanova, Kaylen R. Meeks, Juan Ji, Caitlin J. Mattingly, Jay C. Nix, Mykola V. Protopopov, John J. Tanner   +6 more
semanticscholar   +1 more source

PYCR1 inhibition in multiple myeloma-associated stromal cells limits tumor growth.

2023
Introduction Multiple myeloma (MM) is a hematological cancer, characterized by the accumulation of monoclonal plasma cells in the bone marrow. It remains an incurable cancer due to drug resistance, wherein the bone marrow microenvironment plays a crucial role. We have previously shown that glutamine-to-proline conversion is upregulated in MM cells upon
Oudaert, Inge, Menu, Eline
openaire   +1 more source

Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

Cell Reports, 2022
Abeer Shaaban, Gareth Lavery, Hendrik Luuk   +2 more
exaly  

The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer

Human Cell, 2022
Xiaofeng Qiu, Song Yanan
exaly