Results 131 to 140 of about 159,479 (261)

Biobanking in the Developing World; Maximum Specimens, Minimum Infrastructure

Basic & Clinical Cancer Research, 2018
Biobanking in the Developing World; Maximum Specimens, Minimum ...
Marjan Mohammadi
doaj  

TDP-43-driven alternative splicing of UQCRC2 modulates mitochondrial bioenergetics

Biology Direct
TAR DNA-binding protein 43 (TDP-43) is a nuclear RNA-binding protein. It has emerged as a key regulator of RNA processing, such as alternative splicing events, which are essential for cellular homeostasis.
Xia Xue, Jingwen Hou, Zhiqi Zhang, Zeting Yang, Le Chang, Zengguang Yang, Simeng Liu, Huang Huang, Lu Mei, Yang Mi, Pengyuan Zheng, Xiangdong Sun   +11 more
doaj   +1 more source

The integrated reproductive response: the scope for seasonal phenotypic flexibility shapes reproductive outcomes across fish populations

Oikos, EarlyView.
Across north‐temperate environments, rapid environmental change has disrupted the seasonal life histories of resident organisms, decreasing the reliability of environmental cues. Flexible responses capable of buffering the effects of unpredictable environmental variation to defend performance and reproductive outcomes may thus be key to species‐ and ...
Timothy J. Fernandes, Sofia Pereira, Brian J. Shuter, Bailey C. McMeans   +3 more
wiley   +1 more source

Integrative nomogram model based on anoikis-related genes enhances prognostic evaluation in colorectal cancer

Heliyon
Background: Revealing the role of anoikis resistance plays in CRC is significant for CRC diagnosis and treatment. This study integrated the CRC anoikis-related key genes (CRC-AKGs) and established a novel model for improving the efficiency and accuracy ...
Yuexiao Zhang, Xia Xue, Fazhan Li, Bo Zhang, Pengyuan Zheng, Yang Mi   +5 more
doaj   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Kirigami‐Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery

Small, EarlyView.
We have engineered a kirigami‐inspired deployable microneedle robot (KiriBot) capable of remotely controlled attachment to target tissues for sustained drug release. KiriBot incorporates a flexible structure that enhances conformability, improves adherence to irregular tissues, and facilitates microneedle insertion.
Kun Zhou, Rujie Sun, Yuyang Zuo, David J. Peeler, Jonathan Yeow, Ruoxiao Xie, Junliang Lin, Yiming Ma, Yue Shao, Yuanxiong Cao, Zhengkun Chen, Molly M. Stevens   +11 more
wiley   +1 more source

Apo10 and TKTL1 as novel liquid biopsy biomarkers for early detection of gastrointestinal malignancies

VIEW, EarlyView.
(A) Overview of the study population and schematic illustration showing tumor‐derived apoptotic and metabolic biomarkers, Apo10 and TKTL1, being phagocytosed by circulating monocytes and subsequently detected in peripheral blood. (B) Illustration of the epitope detection in monocytes (EDIM) strategy, using a flow‐cytometric gating approach based on ...
Zhiying Mao, Qiyu Huang, Juan Xiao, Ziyu Liu, Xinyan Zou, Yuying Liu, Lizhi Liu, Musheng Zeng, Chuanbo Xie   +8 more
wiley   +1 more source

Laparoscopic Modified One Anastomosis Gastric Bypass for Severe Obesity After Pancreaticoduodenectomy: A Safe Approach to the Hostile Abdomen, a First Case Report

The Kaohsiung Journal of Medical Sciences, EarlyView.
Chih‐Kun Huang, Ming‐Che Hsin, Long‐Bin Jeng, Ting‐Wei Chang   +3 more
wiley   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source