Results 101 to 110 of about 993 (122)

Design of Cell-Penetrating Domain Antibodies via a Genetically Encoded β-Lactam Amino Acid. [PDF]

Angew Chem Int Ed Engl
Rabb JD, Kruse LE, Lin Q.
europepmc   +1 more source

Hydrophobic tuning with non-canonical amino acids in a copper metalloenzyme. [PDF]

Nat Chem
Fischer S, Natter Perdiguero A, Lau K, Deliz Liang A.   +3 more
europepmc   +1 more source

Cellular Site-Specific Incorporation of Noncanonical Amino Acids in Synthetic Biology. [PDF]

Chem Rev
Niu W, Guo J.
europepmc   +1 more source

Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism. [PDF]

Nature
Dunkelmann DL, Piedrafita C, Dickson A, Liu KC, Elliott TS, Fiedler M, Bellini D, Zhou A, Cervettini D, Chin JW.   +9 more
europepmc   +1 more source

Genetic Code Expansion: Recent Developments and Emerging Applications. [PDF]

Chem Rev
Huang Y, Zhang P, Wang H, Chen Y, Liu T, Luo X.   +5 more
europepmc   +1 more source

Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation. [PDF]

Nat Commun
Furuhata Y, Rix G, Van Deventer JA, Liu CC.   +3 more
europepmc   +1 more source

Incorporation of Multiple β²-Hydroxy Acids into a Protein <i>In Vivo</i> Using an Orthogonal Aminoacyl-tRNA Synthetase. [PDF]

ACS Cent Sci
Hamlish NX, Abramyan AM, Shah B, Zhang Z, Schepartz A.   +4 more
europepmc   +1 more source

An efficient pyrrolysyl-tRNA synthetase for economical production of MeHis-containing enzymes.

Faraday Discuss
Hutton AE, Foster J, Sanders JEJ, Taylor CJ, Hoffmann SA, Cai Y, Lovelock SL, Green AP.   +7 more
europepmc   +1 more source

Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues

Protein Science, 2023
The availability of an expanded genetic code opens exciting new opportunities in enzyme design and engineering. In this regard histidine analogues have proven particularly versatile, serving as ligands to augment metalloenzyme function and as catalytic ...
Sarah Lovelock, Anthony P Green, Florence Hardy   +2 more
exaly   +2 more sources

Ancestral archaea expanded the genetic code with pyrrolysine [PDF]

Journal of Biological Chemistry, 2022
The pyrrolysyl-tRNA synthetase (PylRS) facilitates the cotranslational installation of the 22nd amino acid pyrrolysine. Owing to its tolerance for diverse amino acid substrates, and its orthogonality in multiple organisms, PylRS has emerged as a major ...
Han-Kai Jiang, Takahito Mukai, Xian Fu
exaly   +2 more sources