Results 111 to 120 of about 97,542 (214)

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory. [PDF]

iScience, 2022
Asgarihafshejani A, Honoré È, Michon FX, Laplante I, Lacaille JC.   +4 more
europepmc   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Layer 6A Pyramidal Cell Subtypes Form Synaptic Microcircuits with Distinct Functional and Structural Properties. [PDF]

Cereb Cortex, 2022
Yang D, Qi G, Ding C, Feldmeyer D.
europepmc   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Drugs of Abuse Differentially Alter the Neuronal Excitability of Prefrontal Layer V Pyramidal Cell Subtypes. [PDF]

Front Cell Neurosci, 2021
Leyrer-Jackson JM, Hood LE, Olive MF.
europepmc   +1 more source

Coordination Chemistry of Single‐Atom Catalysts in Expediating Kinetics for Advanced Lithium‐Sulfur Batteries

Advanced Science, EarlyView.
This review elucidates the catalytic mechanisms of single‐atom catalysts (SACs) in accelerating lithium polysulfides redox kinetics. Subsequently, the modifications brought by asymmetric coordination chemistry and dual‐atom coordination structures in terms of geometric configuration engineering, molecular orbital hybridization, and interfacial charge ...
Peng Chen, Jinyuan Zhao, Jing Zhang, Yidong Miao, Weihao Li, Huihua Li, Jian Wang, Yongzheng Zhang   +7 more
wiley   +1 more source

Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations. [PDF]

Nat Neurosci
Jongbloets BC, Chen Y, Muniak MA, Gingerich IK, Maanum KA, Mao T.   +5 more
europepmc   +1 more source

Alpha lipoic acid reverses scopolamine-induced spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of Wistar rats. [PDF]

IBRO Neurosci Rep, 2022
Memudu AE, Adanike RP.
europepmc   +1 more source

Phosphine Coordination to Ce, Nd, Np, and Pu in ArBiAMPtBu‐Supported Complexes and Their 2H and 13C Isotopologues

Advanced Science, EarlyView.
A dianionic ligand designed to encourage metal‐phosphine coordination—bis((3,5‐dimethylphenyl)amidomethyl)tertbutylphosphine (ArBiAMPtBu)—was employed in the synthesis of paramagnetic complexes of Ce, Nd, Np, and Pu, producing MI(ArBiAMPtBu)(thf)3.
Novan A. G. Gray, Yury Minko, Brenna K. Cashman, R. Joseph Lastowski, Adam R. Altenhof, Harris E. Mason, Daniel J. Lussier, Frank MacGregor, Andrew J. Gaunt, Aaron M. Tondreau   +9 more
wiley   +1 more source