Results 51 to 60 of about 12,133,346 (298)

Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior

eLife, 2020
In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity.
Igor Gridchyn, Philipp Schoenenberger, Joseph O'Neill, Jozsef Csicsvari   +3 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity

Frontiers in Neuroanatomy, 2022
Minicolumns are thought to be a fundamental neural unit in the neocortex and their replication may have formed the basis of the rapid cortical expansion that occurred during primate evolution.
Mark N. Wallace, Mark N. Wallace, Oliver Zobay, Oliver Zobay, Eden Hardman, Zoe Thompson, Phillipa Dobbs, Lisa Chakrabarti, Alan R. Palmer, Alan R. Palmer   +9 more
doaj   +1 more source

Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties

PLoS Comput. Biol., 2011
The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column.
Etay Hay, Sean L. Hill, F. Schürmann, H. Markram, Idan Segev   +4 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Changes in Cyclin D1, cdk4, and Their Associated Molecules in Ischemic Pyramidal Neurons in Gerbil Hippocampus after Transient Ischemia and Neuroprotective Effects of Ischemic Preconditioning by Keeping the Molecules in the Ischemic Neurons

Biology, 2021
Inadequate activation of cell cycle proteins including cyclin D1 and cdk4 is involved in neuronal cell death induced by diverse pathological stresses, including transient global brain ischemia.
Tae-Kyeong Lee, Dae Won Kim, Jae-Chul Lee, Cheol Woo Park, Hyejin Sim, Ji Hyeon Ahn, Joon Ha Park, Myoung Cheol Shin, Jun Hwi Cho, Choong-Hyun Lee, Moo-Ho Won, Soo Young Choi   +11 more
doaj   +1 more source

Hippocampal CA1 pyramidal cells form functionally distinct sublayers

Nature Neuroscience, 2011
Hippocampal CA1 pyramidal neurons have frequently been regarded as a homogeneous cell population in biophysical, pharmacological and modeling studies.
K. Mizuseki, K. Diba, E. Pastalkova, G. Buzsáki   +3 more
semanticscholar   +1 more source

Von Economo Neuron Loss in Frontotemporal Dementia: A Meta‐Analysis of Neuropathological Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks.
Daniel Talmasov, Alexander F. Santillo, Patrick R. Hof   +2 more
wiley   +1 more source

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play essential roles in various hippocampal functions, including regulation of long-term potentiation, synaptic plasticity, and hippocampal-dependent cognitive process.
Choong-Hyun Lee, Joon Ha Park, Moo-Ho Won   +2 more
doaj   +1 more source

Differential effects of rapid hypothermia on pyramidal neurons and interneurons in epileptogenic tissue of epileptic patients

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Objective To explore the different effects of rapid hypothermia on the electrophysiological characteristics of pyramidal neurons and interneurons in epileptic patients.
REN Guo⁃ping , YU Tao, XING Yue , CHENG Li⁃peng, WANG Jiao⁃yang , YAN Xiao⁃ming, WANG Qun, ZHANG Guo⁃jun , YANG Xiao⁃feng   +8 more
doaj   +1 more source