Results 151 to 160 of about 63,189 (307)

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice

Autism Research, EarlyView.
ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown.
Krisztina Sáfár, Vivien Szendi, Paulina Hoppa, Yutong Wang, Fanni Á. Seres, Szilvia Bartók, Tyler Teadora, Lei Shi, Árpád Dobolyi, Gina Puska, István Adorján   +10 more
wiley   +1 more source

Visual response properties of the two physiologically defined pyramidal neuron types.

, 2015
(A) Schematic of the turtle ex vivo eye-attached whole-brain preparation. A diffuse flash of light from the LED (red) is projected onto the intact retina within the eye-cup (gray bowl), while the membrane potential from a pyramidal neuron is recorded ...
Nathaniel Wright (833470), Michael Ariel (767269), Thomas Crockett (2202283), Ralf Wessel (833472), Stephen Thornquist (833471)   +4 more
core   +1 more source

Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers

British Journal of Clinical Pharmacology, EarlyView.
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics (CPT) exams, comparing their results to medical students and exploring their ability to identify poorly formulated
Alexandre O. Gérard, Diane Merino, Marc Labriffe, Fanny Rocher, Delphine Viard, Laurence Zemori, Thibaud Lavrut, Erik M. Donker, Joost D. Piët, Jean‐Paul Fournier, Milou‐Daniel Drici, Alexandre Destere   +11 more
wiley   +1 more source

Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex. [PDF]

Neuron, 2023
Babij R, Ferrer C, Donatelle A, Wacks S, Buch AM, Niemeyer JE, Ma H, Duan ZRS, Fetcho RN, Che A, Otsuka T, Schwartz TH, Huang BS, Liston C, De Marco García NV.   +14 more
europepmc   +1 more source

Structure‐Function Tailoring of Plasmonic Nanomaterials for Thin‐Film Photovoltaics

Carbon Energy, EarlyView.
This review discusses the mechanisms and recent advancements of plasmonics in achieving effective light management to enhance the performance of thin‐film solar cells. It highlights applications in high‐performance perovskite solar cells and future‐oriented tandem solar cells.
Sen Jiang, Wenhan Yang, Annan Zhu, Yuexin Lin, Zhaohui Xie, Ran Chen, Wenjing Zhu, Jin Liu, Yingjie Zhu, Wenye Jiang, Zhiyuan Gu, Kaiyang Wang, Shengchun Yang, Nan Zhang, Chao Liang   +14 more
wiley   +1 more source

Dynamics and conditions for inhibitory synaptic current to induce bursting and spreading depolarization in pyramidal neurons

Scientific Reports
Enhanced activity of inhibitory neurons, which is often used to suppress behaviors of pyramidal neurons to treat brain diseases, whereas can enhance spiking to a mixed-mode bursting (MMB) in recent experiments on migraine and seizure.
Hongtao Hua, Huaguang Gu, Kaihua Ma, Yanbing Jia, Liang Wu   +4 more
doaj   +1 more source

High‐Energy‐Density Redox Flow Batteries: Mechanisms, Design Strategies, and Recent Progress

Chemistry – A European Journal, EarlyView.
ABSTRACT The inherent intermittency of energy sources such as solar and wind power hinders the transition to renewable energy, necessitating advanced energy storage solutions. Enhancing energy density is crucial for lowering system costs and enabling large‐scale deployment.
Xiaolian Zhao, Jiaxin Yu, Nannan Jia, Chuzhang Hong, Yue Luo, Wantong Jing, Zhiming Feng, Xinhua Liu, Rui Tan   +8 more
wiley   +1 more source

Plasticity in the Olfactory Cortex Is Enabled by Disinhibition of Pyramidal Neuron Apical Dendrites. [PDF]

J Neurosci, 2022
Loidl R, Abs E.
europepmc   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Quantitative Detection of Entotic Cell‐In‐Cell Structures Using Deformable Segmentation and Deep Learning

Cytometry Part A, EarlyView.
ABSTRACT Cell‐in‐cell (CIC) structures are among the most intriguing cellular phenomena occasionally observed in human cancer specimens. Once regarded as incidental findings, accumulating evidence has linked specific CIC subtypes, particularly entosis, to tumor progression and patient prognosis.
Maria V. Leyba‐Mesa, Mikołaj Biegański, Elijah Ray, Izabela Młynarczuk‐Bialy, Buket D. Barkana   +4 more
wiley   +1 more source