Results 121 to 130 of about 137,757 (233)

Betaine Attenuates Cuprizone‐Induced Cortical Demyelination: The Role of the WNT4/mTOR Signalling Pathway in Regulating Astrogliosis and Synaptic Integrity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Betaine helps to restore the dysfunctional communication between oxidative stress and inflammation, and it also improves demyelination in cuprizone‐induced demyelinating disease within the cerebral cortex. ABSTRACT Cortical grey matter pathology manifests early demyelinating diseases and is a primary driver of permanent neurological impairment.
Yara M. Said, Heba‐Tallah Abd Elrahim Abd Elkader, Gihad Jamal Bekheet, Sherine Abdel Salam, Amina E. Essawy   +4 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

Obsessive–Compulsive Disorder: Comorbidity, Biomarkers, Circuits, and Treatment Strategies

MedComm, Volume 7, Issue 11, November 2026.
OCD has a high comorbidity with other psychiatric conditions, among which anxiety is the most frequent one. The shared genetic biomarkers and common neural circuits underlying the co‐occurrence of OCD and anxiety pave a new path for understanding the pathogenic mechanism of OCD and suggest tailored and integrative treatment therapies for OCD from the ...
Xiao‐Yang Zhang, Zi‐Hao Li, Li‐Ping Shen, Bing‐Qing Kong, Qi‐Peng Zhang, Ya Ke, Juan Tu, Fei Wang, Wing‐Ho Yung, Jing‐Ning Zhu   +9 more
wiley   +1 more source

Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging

, 2000
A novel MRI method-diffusion tensor imaging-was used to compare the integrity of several white matter fibre tracts in patients with probable Alzheimer's disease.
Zelaya, F O; id_orcid, Semple, J, Zelaya, F. O., Benson, M, Rose, S. E., Doddrell, D M, Doddrell, D. M., Chalk, J. B., Benson, M., Strugnell, W E, Rose, S E; id_orcid, Chalk, J B, Chen, F., Strugnell, W. E., Semple, J., Chen, F   +15 more
core   +1 more source

Wallerian degeneration of the pyramidal tract

Deutsches Ärzteblatt international, 2022
Robert, Forbrig, Adrian, Danek
openaire   +2 more sources

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Congenital Intraoral Synechiae: A Scoping Review of Airway, Feeding, and Surgical Management

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 5, Page 965-976, November 2026.
Abstract Objective To map the existing literature on congenital intraoral synechiae and summarize reported anatomic patterns, clinical presentation, associated anomalies/syndromes, and outcomes to inform standardized diagnostic and therapeutic approaches. Data Sources PubMed, CINAHL, Embase, Web of Science, and Google Scholar were searched from January
Jason Bernier, Mathieu Bergeron
wiley   +1 more source

A Model for Estimating the Risk of Gastrointestinal Bleeding for Patients on Oral Anticoagulants and Interacting Medications

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 11, November 2026.
ABSTRACT Introduction Pharmacodynamic drug–drug interactions (DDI) in patients receiving oral anticoagulants (OAC) may increase the risk of gastrointestinal bleeding (GIB). The purpose of this study was to develop and validate a GIB model for patients receiving OACs.
Ainhoa Gomez‐Lumbreras, Abdelrahman G. Tawfik, Thomas Reese, Daniel M. Witt, Guilherme Del Fiol, Daniel C. Malone   +5 more
wiley   +1 more source

Depositional History of the Otis Peak Formation, Western Fan, Jezero Crater, Mars

Journal of Geophysical Research: Planets, Volume 131, Issue 11, November 2026.
Abstract The Mars 2020 Perseverance rover mission spent ∼250 sols investigating the Otis Peak formation (OPfm), a sequence of rocks containing the youngest recorded interval of sediment deposition via aqueous activity on Jezero crater’s western fan. This study uses orbiter and rover observations to interpret the formation and emplacement history of the
Samantha Gwizd, Kathryn M. Stack, Michael P. Lamb, Libby R. W. Ives, Sanjeev Gupta, Alicia Vaughan, Steven Sholes, Rachel Kronyak, Nicolas Randazzo, Justin I. Simon, Larry Crumpler, Jim Rice, Briony Horgan, Linda Kah, Natalie Cavallo, Nathan Williams, Robert Barnes, Opal Ciancolo, Cathy Quantin‐Nataf, Olivier Beyssac, Vivian Sun, David Shuster, Joana R. C. Voigt, James F. Bell III, Justin Maki, Kirsten Siebach, Marion Nachon   +26 more
wiley   +1 more source

DTI-based visualization strategies for the pyramidal tract

, 2006
With the introduction of diffusion tensor imaging a method became available which is capable to detect major white matter tracts in-vivo. For the visualization of the data several techniques have been developed which, however, show various drawbacks for ...
Enders, F, Enders, Frank, Stamminger, M, Stamminger, Marc, Fahlbusch, R, Nimsky, C, Hastreiter, P, Nimsky, Christopher, Merhof, Dorit, Hastreiter, Peter, Merhof, D, Fahlbusch, Rudolf   +11 more
core   +1 more source