Results 41 to 50 of about 137,757 (233)

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

T-value significance maps superimposed on the main white matter tracts.

, 2015
T-value significance maps of the association between homocysteine and mean diffusivity (MD) (a-d) and axial diffusivity (AD) (e-h) were superimposed on the four major white matter tracts that were involved: the pyramidal tracts (a,e), ponto-cerebellar ...
Alexander Leemans (139263), Chyi-Huey Bai (125262), Jung-Lung Hsu (693539), Wei-Hung Chen (693540), Jyu-Gang Leu (693541), Chien-Yeh Hsu (345486), Max A. Viergever (147956)   +6 more
core   +1 more source

Degeneration of the pyramidal tracts in motor neuron disease (MND) examined by cranial MRI and neuropathological analysis [PDF]

, 1993
The degeneration of the intracranial pyramidal tracts in the patients with motor neuron disease (MND) was studied using magnetic resonance imaging (MRI) and neuropathological analysis. Nineteen patients with MND and 51 normal subjects were examined using
三井, 良之, Mitsui, Yoshiyuki
core   +1 more source

The first pediatric case of leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) from Turkey

The Turkish Journal of Pediatrics, 2018
Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is defined as an autosomal recessive inheritance disorder characterized by slowly progressive cerebellar, pyramidal and dorsal column dysfunction.
Dilek Çavuşoğlu, Nihal Olgaç-Dündar, Özgür Öztekin, Taha Reşid Özdemir, Pınar Arıcan, Pınar Gençpınar   +5 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Clinical and magnetic resonance imaging features in acute ischemic stroke with early wallerian degeneration: a case-control study

BMC Neurology
Background In advanced stages, Wallerian degeneration (WD) after cerebral infarction appears as an abnormality in the descending corticospinal tract on T2-weighted images. However, early WD in this region is detectable via diffusion-weighted imaging (DWI)
Kazumichi Ota, Yoshihiko Nakazato, Kazuhide Seo, Hitoshi Kawasaki, Mariko Okada, Takashi Mithufuji, Yasuo Ito, Toshimasa Yamamoto   +7 more
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Monosynaptic connections between pairs of spiny stellate cells in layer 4 and pyramidal cells in layer 5A indicate that lemniscal and paralemniscal afferent pathways converge in the infragranular somatosensory cortex. [PDF]

, 2005
Monosynaptic interlaminar connections between spiny stellate cells in layer 4 (L4), the main cortical recipient layer for thalamic projections, and pyramidal cells in layer 5A (L5A), one of the main cortical output layers, were examined anatomically and ...
Feldmeyer, D, Feldmeyer, D., Sakmann, B, Roth, A., Roth, A, Sakmann, B.   +5 more
core   +1 more source