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Synthesis and Antimycobacterial Evaluation of Novel Pyrazole‐Isoxazolines and Pyrazole‐Isoxazoles
ChemBioChemAbstractThis study reports the synthesis of a new series of pyrazole‐isoxazolines, at very good yields, from the cyclocondensation reaction of pyrazole‐enaminones with hydroxylamine hydrochloride. Dehydration of the pyrazole‐isoxazolines furnished another new series of the respective pyrazole‐isoxazoles, at excellent yields. Both series of the obtained
Paulo A. Moraes +10 more
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Thermal rearrangements of 3H-pyrazoles, 4H-pyrazoles, and cyclopentadienes
19923H-Pyrazoles generally undergo thermal rearrangement by concerted [1,5]-sigmatropic migrations. It has been discovered that 3H-pyrazoles 111a-e undergo thermal rearrangement by an alterative mechanism. A stepwise, ion-pair, mechanism operates in these rearrangements, in benzene/toluene, chloroform, and methanol solvents.
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Pyrazoles VII: nitration of 1,4-disubstituted pyrazoles
Tetrahedron Letters, 1970Clarisse L. Habraken +3 more
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2001
The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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