KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee+13 more
wiley +1 more source
Natural asphalt oxide-grafted carboxylic acid: a sustainable heterogeneous catalyst for synthesis of pyrano[2,3-<i>c</i>]pyrazoles and 2-amino-3-cyanopyridines in water. [PDF]
Rashidi S, Soleiman-Beigi M.
europepmc +1 more source
Synthesis and reaction of 1-(N,N-disubstituted amino)pyrazoles.
SHOJI KISHIMOTO+2 more
openalex +2 more sources
APPi: A Multiscale Qualitative–Quantitative Insecticide‐Likeness Evaluation Platform and Application
An Agrochem Predictive Platform for Insecticide‐likeness: From Qualitative Rules to Quantitative Modeling and Visualization. ABSTRACT According to the Food and Agriculture Organization of the United Nations (FAO), pests reduce global crop production by 14% annually. The growing challenge of pest resistance, coupled with the relatively low success rates
Jia‐lin Cui+7 more
wiley +1 more source
Dual Excitation and Dual Emission in a 1,4‐Diazepine Bearing an Extended π‐System
Cyclodehydrogenation of a previously reported nanographene BDI leads to the formation of a 1,4‐diazepine via scandium‐catalyzed C‐H bond formation. This compound exhibits a unique combination of dual excitation and dual emission. The dual emission was found to be caused by a combination of charge transfer and geometric relaxation in the excited state ...
Lars Killian+6 more
wiley +1 more source
Eco-friendly methods for the synthesis of <i>N</i>-acyl pyrazole derivatives with luminescent properties. [PDF]
Świętczak E+2 more
europepmc +1 more source
Synthetic Inhibitors of Alcohol Dehydrogenase. Pyrazoles Containing an Unsaturated Hydrocarbon Residue in the 4-Position. [PDF]
Bo‐Ragnar Tolf+6 more
openalex +1 more source
Pyrazole Based Inhibitors against Enzymes of Staphylococcus aureus:A Computational Study [PDF]
Aravindhan, S.+6 more
core +1 more source