Results 141 to 150 of about 40,394 (295)
, 2011 International audienceA series of N-aryl and N-heteroaryl pyrazoles have been deproto-metallated using a 2,2,6,6-tetramethylpiperidino-based mixed lithium-zinc combination.
Chevallier, Floris +8 more
core +2 more sources
Unraveling Lignin's Color Puzzle: From Chromophore Origins to Advanced Decolorization Strategies
Aggregate, Volume 7, Issue 1, January 2026.This review provides a comprehensive systematic analysis of the research advancements in lignin color formation mechanisms and decolorization techniques, specifically focusing on three principal approaches: hydroxyl shielding, biomass fractionation, and physical methods. It highlights the systematic research approach of the review toward decolorization
Lizhen Huang, Zhuotong Wu, Li Shuai
wiley +1 more source
A Proteochemometric Model for Ligands of the SLC5 Transporter Family
Archiv der Pharmazie, Volume 359, Issue 1, January 2026.A novel proteochemometric model was developed to predict the activity and selectivity of SLC5 family inhibitors. The model's performance was validated using 10‐fold cross‐validation on publicly available datasets achieving Q2 = 0.79 and MSE < 0.32. Detailed analysis of the results enabled the identification of a new, previously unrecognized selectivity‐
Martin Juhás, Gerhard Ecker
wiley +1 more source
Discovery of New Pyrazole‐Tosylamide Derivatives as Apoptosis Inducers Through BCL‐2 Inhibition and Caspase‐3 Activation [PDF]
Burak Kuzu, Ege Arzuk
openalex +1 more source
Crystal structure of 1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-5-((3-bromophenyl) methyleneimino)-1H-pyrazole-3-carbonitrile, C18H8BrCl2F3N4 [PDF]
, 2006 X.-G. Zhang, X.-H. Zhang, Ping Zhong
openalex +1 more source
ChemistryEurope, Volume 4, Issue 1, January 2026.This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink +3 more
wiley +1 more source
Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas
ChemMedChem, Volume 21, Issue 1, January 2026.Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci +6 more
wiley +1 more source
Customizing Native Chemical Ligation: A Case Study on Histone Variant H2A.B from Toolbox to Target
Chemistry–Methods, Volume 6, Issue 1, January 2026.The core histone protein variant H2A.B, chosen as the target protein, is involved in many transcriptional processes regulated by its post‐translational modifications. Herein, the native chemical toolbox is harnessed to demonstrate the successful synthesis and semi‐synthesis of site‐specifically modified H2A.B variants via different strategies.
Tobias Gökler +4 more
wiley +1 more source