Results 131 to 140 of about 53,373 (308)

On the regiospecificity of 3,5-disubstituted pyrazoles derived from C-acylated-β-enaminonitriles and esters

, 2005
Regiospecificity of 3,5-disubstituted pyrazoles derived from reaction of phenylhydrazine with α-acyl-β-amino-crotononitriles and esters is primarily deduced on the basis of spectral analyses.
Sarkar, M., Mukherjee, A., Chowdhury, S. K. Dutta, Chatterjee, A., Mahalanabis, Kumar K., Mishra, M.   +5 more
core   +1 more source

Electron-impact Mass-spectrometry of Trifluoromethyl-substituted 4,5-dihydro-1h-pyrazoles and 4,5-dihydro-3h-pyrazoles

, 1992
The mass spectrometric behaviour of two trifluoromethyl-substituted 4,5-dihydro-3H-pyrazoles and of their corresponding regioisomers 4,5-dihydro-1H-pyrazoles has been studied and compared with that of two non-fluorinated analogues.
L. BRUCHE, P. BRAVO, FAVRETTO, DONATA, D. DILIDDO, P. TRALDI   +4 more
core  

Curcumin derived pyrazoles and related compounds [PDF]

, 2016
In this comprehensive review we discuss the publications reporting pyrazoles derived from curcumin, curcuminoids and hemi-curcuminoids (149 examples) together with some biological and pharmacological ...
Claramunt, R.M., Elguero, J., Sanz, D., Nieto, C.I.   +3 more
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Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP‐activated protein kinase signalling

British Journal of Pharmacology, Volume 183, Issue 21, Page 6501-6518, November 2026.
Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca, Patricia Raposo Afonso, Valentin Morfin, James Cantley, Jenni Harvey   +4 more
wiley   +1 more source

A KATing Edge Perspective on KAT6A Inhibitors as Anticancer Agents

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
This perspective efficiently summarizes the development of lysine acetyltransferase (KAT) inhibitors as anticancer agents, and the most clinically advanced KAT6A inhibitor, prifetrastat, entered Phase III clinical trials in 2025. KAT6A structural biology and structure activity relationships for acylsulfonylhydrazides, [1,2,4]thiadiazines, and ...
Rochelle Woodland, Adi Suwandi, Awgichew Behaile Teklemariam, Nidhish Francis, Li Li, Kenneth A. Chinkwo, Jonathan B. Baell, David J. Leaver   +7 more
wiley   +1 more source

Synthesis of 5-ferrocenyl-4-((4-nitrophenyl)sulfenyl)-1H-pyrazoles by electrophilic cyclization

, 2011
Pyrazoles have been intensely studied in the design and synthesis of biologically active agents because they display considerable medicinal activities. Recent studies have shown that integration of a ferrocenyl unit with structural features of pyrazoles ...
FULYA KARAHAN DAĞ
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4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source

A de‐novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly‐Controlled Kinetic Electron Transfer Gating

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha, Rajesh Kancherla, Jorge Escorihuela, Shana Chandran, Mrinal K. Bera, Magnus Rueping, Burkhard König   +6 more
wiley   +2 more sources

TADF‐Active Tetrazole Luminophores for Visible‐Light Functionalization of Nanoparticles and Surfaces

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
A series of tetrazoles are reported that undergo 1,3‐dipolar cycloadditions with alkene and alkyne substrates, generating (dihydro)pyrazole products that exhibit thermally activated delayed fluorescence (TADF). The “photo‐click” reactivity of these tetrazoles is leveraged to functionalize nanoparticles and surfaces with TADF‐active chromophores ...
Ryoga Hojo, Katrina Bergmann, Siyuan L. Xie, Connor S. Durfy, William L. Primrose, Athan T. Gogoulis, Seja A. Elgadi, Mitchell J. Demchuk, Thomas Kalab, Peiqi Hu, Eva M. Nichols, Zachary M. Hudson   +11 more
wiley   +2 more sources

High-pressure activation for the solvent- and catalyst-free syntheses of heterocycles, pharmaceuticals and esters

Beilstein Journal of Organic Chemistry
High hydrostatic pressure (HHP) was found to be an efficient activation method in several catalyst- and solvent-free reactions and has found application for the syntheses of heterocycles and the preparation of active pharmaceutical ingredients (APIs) via
Kelsey Plasse, Valerie Wright, Guoshu Xie, R. Bernadett Vlocskó, Alexander Lazarev, Béla Török   +5 more
doaj   +1 more source