Results 131 to 140 of about 19,339 (247)

N‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
N‐Alkoxysulfurdiimide reagents when combined with organometallic reagents lead directly to primary sulfonimidamide products. The reactions are broad in scope, encompassing aryl, heteroaryl, and alkyl carbon substituents. The reactivity of the N‐alkoxysulfurdiimide reagents can be correlated with the electron‐withdrawing ability of the N‐substituent ...
Suzanne E. Davison, Jonathan A. Andrews, Agamemnon E. Crumpton, Mireia Sidera Portela, Michael A. Clegg, Damien Valette, Michael C. Willis   +6 more
wiley   +2 more sources

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo, Zhuoyao Chen, Laurine Palluaud, Arpad Kiss, Tibor Novak, Andras Herner, Alex N. Bullock, Virginie Martiny, Andras Kotschy   +8 more
wiley   +1 more source

Synthesis and Reactions of Hydrazine Trifluoroborate Salts. [PDF]

Org Lett
Ballerini L, Zhao W, Tarasewicz A, Méndez M, Harrity JPA.   +4 more
europepmc   +1 more source

Influence of Oxidation State on the Catalytic Activity of Iron Catalysts for CO2 Fixation to Cyclic Carbonates

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
Air stable bimetallic iron one‐component systems capable of CO2 cycloaddition to epoxides under 1 bar of pressure of CO2. In this work, one‐component iron catalysts for the atom‐economical reaction of CO2 with epoxides have been used as efficient catalysts for the carbon dioxide cycloaddition into cyclic carbonates in excellent yields.
María P. Caballero, Marta Navarro, Marc Martínez de Sarasa Buchaca, Jesús Naranjo, Alberto Moreno‐Fernandez, Antonio Rodríguez‐Diéguez, Pablo Salcedo‐Abraira, José A. Castro‐Osma, Juan Tejeda, Felipe de la Cruz‐Martínez, Agustín Lara‐Sánchez   +10 more
wiley   +1 more source

Three privileged scaffolds, one pipeline: chalcones, pyrazolines and pyrazoles in drug discovery and fluorescent sensing. [PDF]

RSC Med Chem
Ciupa A.
europepmc   +1 more source

Photochemisch erzeugte Oxetane als Schlüssel zur endergonen Cyclopropansynthese

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
Eine neuartige Oxetan‐zu‐Cyclopropan‐Umlagerung eröffnet einen atomökonomischen Zugang zu dicht funktionalisierten Cyclopropanen aus Furanen und photochemisch aktivierten Aldehyden. Die erhaltenen Strukturen erschließen komplexe bioaktive Motive und fungieren als vielseitige Plattform für die asymmetrische Cyclopropansynthese.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

Copper-catalysed site-selective arylation of pyrazoles. [PDF]

Nat Chem
Wang M, Hou X, Corio SA, Digal L, Hirschi JS, Dong VM.   +5 more
europepmc   +1 more source

Enantioselective Pyrazole Alkylation via Iridium and Squaramide Catalyzed N-H Insertion. [PDF]

J Am Chem Soc
Ruud KJ, Antonucci AJ, Lukovic V, Vennemeyer A, Dong VM.   +4 more
europepmc   +1 more source

A photochemical strategy for pyrazole to imidazole conversion. [PDF]

Chem Sci
Wei Y, Kasama K, Igartua A, Yildiz DB, Ceuninck A, Dos Santos T, Büttner C, Thevenet D, Bossart M, Derdau V, Méndez M, Jubault P, Poisson T, Roure B, Leonori D.   +14 more
europepmc   +1 more source