Results 111 to 120 of about 37,807 (249)
Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
Molecules, 2017 In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation.
Sobhi M. Gomha +4 more
doaj +1 more source
Filling the Gap: Chemistry of 3,5-Bis(trifluoromethyl)-1H-pyrazoles
, 2012 Pyrazoles represent important building blocks for the preparation of bioactive compounds and a large variety of materials, due to their rich coordination chemistry.
Monticelli D +5 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli +8 more
wiley +1 more source
Düzce Tıp Fakültesi DergisiAim: This study aimed to synthesize a novel pyrazole acridine derivative (3-ACH) and evaluate its anticancer properties on SH-SY5Y human neuroblastoma cells.Material and Methods: The pyrazole-4-carbaldehyde derivative was cyclized with dimedone and p ...
Muna Elmusa +5 more
doaj +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT This study characterized the long‐term pharmacokinetic profile of a 1% fipronil pour‐on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil and its metabolites (sulfone and desulfinyl) were monitored for 175 days using LC–MS/MS.
Stefani Maria Ferreira +8 more
wiley +1 more source
An Exploration of Vinamidinium Salts for Frame‐Shifted Synthesis
Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.Oligoheterocycles are widely used in drug discovery and materials science, where they serve as attractive alternatives to peptide fragments. There is strong interest in understanding the structural correspondence between heterocycles and amino acid motifs to recapitulate key binding elements while improving metabolic stability.
Morgan J. Cordell +3 more
wiley +1 more source
, 1992 The mass spectrometric behaviour of two trifluoromethyl-substituted 4,5-dihydro-3H-pyrazoles and of their corresponding regioisomers 4,5-dihydro-1H-pyrazoles has been studied and compared with that of two non-fluorinated analogues.
L. BRUCHE +4 more
core
Machine Learning Accelerates Crystallization for Structure Determination
Angewandte Chemie International Edition, EarlyView.Single‐crystal X‐ray diffraction (SCXRD) is often constrained by the difficulty of obtaining suitable crystals. Here, a machine learning‐accelerated co‐crystal discovery workflow is established for a crystalline mate strategy that achieves over 95% prediction accuracy and experimentally delivers 114 co‐crystals from 120 candidates.
Cui‐Zhou Luan +10 more
wiley +1 more source
Azide‐to‐Diazo Transformation Facilitated by Michael Addition via Phosphazide Formation
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.A new type of Michael addition based on azide‐to‐diazo conversion is disclosed. This unusual transformation proceeds via 1,4‐addition accompanied by N─N bond cleavage of phosphazide intermediates under practical conditions. The high versatility of the resulting Michael adducts enables the synthesis of a wide variety of organonitrogen compounds ...
Tomoki Mano +3 more
wiley +2 more sources
Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou +10 more
wiley +1 more source