Results 111 to 120 of about 19,339 (247)
Curcumin derived pyrazoles and related compounds [PDF]
, 2016 In this comprehensive review we discuss the publications reporting pyrazoles derived from curcumin, curcuminoids and hemi-curcuminoids (149 examples) together with some biological and pharmacological ...
Claramunt, R.M. +3 more
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Zinc-Catalyzed Synthesis of Pyrazolines and Pyrazoles via Hydrohydrazination
, 2016 A novel regioselective synthesis of aryl-substituted pyrazolines and pyrazoles has been developed. Substituted phenylhydrazines react with 3-butynol in the presence of a catalytic amount of zinc triflate to give pyrazoline derivatives.
Matthias Beller (1315956) +3 more
core +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Synthesis of Substituted Pyrazoles and Imidazolium Salts
, 2019 This summer research was based in organic chemistry. It consisted of pyrazole and imidazolium chloride salt synthesis. Heterocyclic molecules, pyrazoles and imidazolium salts contain three carbon atoms and two nitrogen atoms in their 5-membered rings. In
Nnabuife, Christina
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Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Hydrogen bonding lights up overtones in pyrazoles
, 2007 The spectral complexity in the NH stretching mode of hydrogen-bonded pyrazoles is traced back to an extensive Fermi resonance system involving combinations and overtones of at least four aromatic ring modes with significant in plane hydride bending ...
C. A. Rice +7 more
core +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca +4 more
wiley +1 more source
Synthesis of some new 1,3,5-trisubstituted pyrazoles as antioxidant and antiinflammatory agents
, 2019 A series of some new 1,3,5-trisubstituted pyrazoles was synthesized by the reaction of α-β dibromochalcones with phenylhydrazine hydrochloride.
Singh, Jitender +2 more
core +1 more source
Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr‐Pyrazole Chemistry
ChemMedChem, Volume 21, Issue 17, 14 September 2026.The glycopeptide antibiotics (GPAs) are important clinical antibiotics. While chemoenzymatic synthesis of more hydrophilic GPAs like vancomycin has aided our understanding of GPA crosslinking, hydrophobic GPAs remain underexplored. Here, we show that modified Knorr‐pyrazole chemistry improves access to hydrophobic peptidyl‐CoAs, with such substrates ...
Jemma Gullick +4 more
wiley +1 more source
Study of the reactivity of alpha-acylenaminoketones. Synthesis of pyrazoles
, 2015 The reactions of 4-(methylamino)-3-penten-2-one with diazoketones yielded the alpha -acylenaminoketones 1-3 in good yields. Preparation of the alpha -acylenaminoketone 4 was carried out by treatment of 4-(t-butylamino)-3-penten-2-one with benzoyl ...
Kascheres, C, Negri, G
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