Results 111 to 120 of about 24,009 (260)
New chemistry of diazafulvenium methides: one way to pyrazoles [PDF]
, 2006 Diazafulvenium methides generated from the solution pyrolysis of pyrazolo[1,5-c][1,3]thiazole-2,2-dioxides participate in [8[pi]+2[pi]] cycloadditions giving pyrazolo[1,5-a]pyridine derivatives.
Gonsalves, António M. d'A. Rocha +2 more
core +1 more source
Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways
European Journal of Organic Chemistry, EarlyView.Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian +3 more
wiley +1 more source
New Pyrazolyl Thioureas Active against the Staphylococcus Genus
PharmaceuticalsTo meet the urgent need for new antibacterial molecules, a small library of pyrazolyl thioureas (PTUs) was designed, synthesized and tested against difficult-to-treat human pathogens.
Anna Maria Schito +6 more
doaj +1 more source
Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
Molecules, 2017 In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation.
Sobhi M. Gomha +4 more
doaj +1 more source
Synthesis and biological evaluation of novel pyrazole derivatives as urease inhibitors [PDF]
, 2011 Studies on enzyme inhibition remain an important area of pharmaceutical research since these studies have led to the discoveries of drugs useful in a variety of physiological conditions.
Bole, S.B. +5 more
core
Photochemical Decatungstate‐Catalyzed Hydroacylation of Maleimides
European Journal of Organic Chemistry, EarlyView.A photocatalytic protocol to access substituted succinimides via tetra‐n‐butylammonium decatungstate photocatalysis is reported. This direct radical‐driven hydroacylation of a variety of N‐substituted maleimides shows tolerance to various aldehydes (or alkanes), affording differentially substituted succinimides in high yields. Succinimides constitute a
Manos V. G. Lantzanakis +2 more
wiley +1 more source
Düzce Tıp Fakültesi DergisiAim: This study aimed to synthesize a novel pyrazole acridine derivative (3-ACH) and evaluate its anticancer properties on SH-SY5Y human neuroblastoma cells.Material and Methods: The pyrazole-4-carbaldehyde derivative was cyclized with dimedone and p ...
Muna Elmusa +5 more
doaj +1 more source
Studies with Arylhydrazono-3-oxopropanals:A novel route to synthesis of substituted pyrazoles, oxoalkanonitrile and glyoxalonitrile containing sulfa drug moieties [PDF]
, 2008 Coupling of enaminones 1 with diazonium salts gave thehydrazonopropanals 3a-h. Compound 3 react with ω-bromoacetophenone or α-chloroacetanilide to yield 5 and 8. These compounds were cyclized smoothly into 6 and 9 respectively.
Abdel Hafiz, I.S. +4 more
core
1,2‐Diazetidines − Structure, Synthesis, and Functionalization
European Journal of Organic Chemistry, EarlyView.1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley +1 more source
Electron, EarlyView.By constructing an isoreticular Cu3‐cluster‐based metal–covalent organic framework platform with systematically tunable π‐conjugation, the physicochemical properties can be finely modulated within a well‐defined structural framework, thereby establishing a precise conjugation–performance correlation to govern the charge separation/transport, and thus ...
Yu‐Qi Zhang +8 more
wiley +1 more source