Results 141 to 150 of about 53,373 (308)

Cyclopropylamine‐Derived Distonic Iminium Radicals: Photoinduced Strategies in Chemo‐ and Stereo‐Selective Synthesis

open access: yesChemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua   +3 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

open access: yesChemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles

open access: yes, 2004
Initially the perfluoroacylation of a range of commercially available vinyl ethers and conversion of the resulting perfluoroacylated enol ethers to 1-H-pyrazoles via reaction with hydrazine is reported.
Laurence Oleksik (7639400)
core   +2 more sources

Chiral Pyrazolinylidene Complexes for Asymmetric Catalysis

open access: yesChemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
The synthesis and application of pyrazolin‐5‐ylidene NHC chiral‐at‐ruthenium catalysts is reported. The strong donating pyrazolin‐5‐ylidene ligands led to highly electron rich ruthenium complexes, which showed excellent catalytic activity and enantioselectivity in the intramolecular aziridination of an alkene.
Felix Möller   +6 more
wiley   +1 more source

Multistep Changes in Spin‐Crossover Temperature Induced by Stepwise Desolvations

open access: yesChemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
A novel Fe(II) complex (1·3VN) exhibits SCO behavior in which the spin transition temperature sequentially increases and then decreases by stepwise removal of valeronitrile (VN) molecules. These non‐monotonic changes in the transition temperature are explained by the changes in intermolecular interactions among the Fe complex and each valeronitrile ...
Taisei Suzuki   +10 more
wiley   +1 more source

Flavin Catalysts in Organic Synthesis

open access: yesAngewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

Green Synthesis of Pyrazoles: Recent Developments in Aqueous Methods

open access: yesSynOpen, 2023
Sushma Singh   +3 more
doaj   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

open access: yesChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova   +3 more
wiley   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic   +3 more
wiley   +1 more source

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