Results 161 to 170 of about 37,807 (249)

Development of a Cu‐Catalyzed Regioselective Hydrazidation of 1,2‐Diborylalkenes

Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
Alkene 1,2‐diboronate esters undergo a Cu‐catalyzed regioselective addition to azodicarboxylates to generate functionalized borylated hydrazides. An investigation of mono‐ versus di‐hydrazidation processes and the use of these products in synthesis are described.
Kavya Gopakumar, Sam Gallagher, Guillaume Benoit, Werngard Czechtizky, Joseph P. A. Harrity   +4 more
wiley   +1 more source

[3 + 2]-Cycloaddition of in Situ Generated Nitrile Imines and Acetylene for Assembling of 1,3-Disubstituted Pyrazoles with Quantitative Deuterium Labeling.

Journal of Organic Chemistry, 2018
V. Voronin, M. Ledovskaya, E. Gordeev, K. Rodygin, V. Ananikov   +4 more
semanticscholar   +1 more source

Catalysis with Ring Strain - Efforts towards Pyrazoles and Cyclic Tripeptides

Transition-metal catalysis with strained rings offers unique opportunities to unlock challenging bond constructions with implications in drug discovery.
Wang, Minghao
core  

Pyrazole Compound [PDF]

, 2020
openaire   +1 more source

Synthesis and Modular Reactivity of Pyrazole 5-Trifluoroborates: Intermediates for the Preparation of Fully Functionalized Pyrazoles.

Journal of Organic Chemistry, 2017
Prisca Fricero, Laurent Bialy, Andrew W. Brown, Werngard Czechtizky, M. Méndez, J. Harrity   +5 more
semanticscholar   +1 more source

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Alkynes and Nitrogen Compounds: Useful Substrates for the Synthesis of Pyrazoles

Chemistry - A European Journal, 2020
The easy preparation and functionalization of pyrazoles associated with their innumerable biological properties have made this class of N -heterocycles very attractive for the development of new synthetic routes and applications.
JOSÉ S S Neto, Gilson Zeni
exaly   +2 more sources

A Unified Continuous Flow Assembly‐Line Synthesis of Highly Substituted Pyrazoles and Pyrazolines

Angewandte Chemie - International Edition, 2017
A rapid and modular continuous flow synthesis of highly functionalized fluorinated pyrazoles and pyrazolines has been developed. Flowing fluorinated amines through sequential reactor coils mediates diazoalkane formation and [3+2] cycloaddition to ...
Joshua Britton, Timothy F Jamison
exaly   +2 more sources

Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study.

International Journal of Biological Macromolecules, 2021
Type 2 diabetes mellitus (DM) is a complex chronic disorder and a major global health problem. Insulin resistance is the primary detectable abnormality and the main characteristic feature in individuals with type 2 DM.
Sónia Rocha, M. Lucas, Vera L. M. Silva, Pedro M O Gomes, Artur M. S. Silva, A. Araújo, Natália Aniceto, R. Guedes, M. Corvo, E. Fernandes, M. Freitas   +10 more
semanticscholar   +1 more source

Fluorinated Pyrazoles: From Synthesis to Applications.

Chemical Reviews, 2020
Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s, their popularity has grown exponentially.
Pavel K. Mykhailiuk
semanticscholar   +1 more source

Synthesis of Trifluoromethylated Pyrazolidines, Pyrazolines and Pyrazoles via Divergent Reaction of β-CF3-1,3-Enynes with Hydrazines.

Organic Letters, 2021
Three types of trifluoromethylated pyrazolidines, pyrazolines, and pyrazoles can be synthesized via divergent reaction of β-CF3-1, 3-enyne with hydrazines. The reaction with simple hydrazine monohydrate or sulfonyl hydrazines as nucleophiles produces 1,3,
Lanlan Wei, Shiteng Ding, Mingqing Liu, Zongxiang Yu, Yuanjing Xiao   +4 more
semanticscholar   +1 more source