Results 181 to 190 of about 53,373 (308)

Recent Advances in Pyrazole-Based Cholinesterase Inhibitors: Medicinal Chemistry Perspectives from 2020 to 2025. [PDF]

Pharmaceuticals (Basel)
Yeysin L, Akın D, Çalışkan S, Hasanoğlu Özkan E, Hashem H, Akocak S, Bräse S, Çete S.   +7 more
europepmc   +1 more source

2‐Chloro‐5‐(trifluoromethyl)aniline‐Derived Schiff Base Palladium(II) Complexes: From Molecular Design to Acute Toxicity Assessment

ChemistryOpen, Volume 15, Issue 10, October 2026.
Four new Schiff bases derived from 2‐chloro‐5‐(trifluoromethyl)aniline and their corresponding palladium(II) complexes were obtained and analyzed by multiple spectroscopic techniques. Single‐crystal X‐ray diffraction elucidated the structures of all the ligands and complexes 2 and 4. Their toxicity was assessed on Triticum aestivum L.
Andreea Elena Ştefan, Cristina Elena Dinu‐Pîrvu, Sergiu Shova, Ştefania Felicia Bărbuceanu, Teodora Venera Apostol, Diana Carolina Ilieş, Mihaela Badea, Mihaela Dinu, Robert Viorel Ancuceanu, Doina Drăgănescu, Elena Pahonţu   +10 more
wiley   +1 more source

Synthesis, molecular docking and biological evaluation of 2,4-diaminopyrimidines and pyrazoles as aurora kinase inhibitors. [PDF]

EXCLI J
Sankhe K, Jadhav M, Prabhu A, Khan T.
europepmc   +1 more source

Exploration of Pyrazole‐Sulfonamide Hybrids: Synthesis, Molecular Modeling, Potential Antimicrobial, DHFR Inhibitor, and Pharmacokinetic Profile

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Nine pyrazole‐sulfonamide hybrids 5, 6, and 7 were synthesized and characterized by IR, NMR, and MS. The DFT computations of the built hybrids presented a comparable non‐planar configuration. Comparable HOMO‐LUMO structures were observed, except for the nitro‐derivatives 5c and 6c.
Adhwa A. Alharbi, Manal S. Ebaid, Asmaa L. Alanzy, Adel I. Alalawy, Basma Abbas, Khadra B. Alomari, Roba M. S. Attar, Nashwa M. El‐Metwaly   +7 more
wiley   +1 more source

Experimental and MEDT Study of Sydnone-Alkyne Cycloaddition-Based Synthesis of 1,4-Disubstituted Pyrazoles and In Silico Investigation of Their Binding to HCV and HIV Proteins. [PDF]

Molecules
Zerbib S, Eddahmi M, Alaqarbeh M, Bodet PE, Thiery V, Fatimi A, Cruz-Martins N, Bailly C, Domingo LR, Bouissane L.   +9 more
europepmc   +1 more source

Estradiol—PGC‐1 signaling in mitochondrial health: Implications for perimenopause and cardiovascular disease

Physiological Reports, Volume 14, Issue 20, October 2026.
Abstract Cardiovascular disease (CVD) is the leading cause of death in aging women. While CVD etiology is multifactorial, mitochondrial dysfunction, characterized by reduced content, impaired energy production, and increased oxidative stress, is an underlying contributor.
Alyssa L. Parten, Glenn C. Rowe
wiley   +1 more source

Photo-Triggered, Fast, and Fluorogenic Thiophene-Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3-Dipole-Tagged Molecules in No-Wash Conditions. [PDF]

Angew Chem Int Ed Engl
Schulz J, Chinoy ZS, Khalaf T, Li Y, Ma P, Svatunek D, Houk KN, Friscourt F.   +7 more
europepmc   +1 more source

Scientific support for preparing an EU position in the 57th session of the codex committee on pesticide residues (CCPR)

EFSA Journal, Volume 24, Issue 10, October 2026.
Abstract The European Commission asked EFSA to provide support in the framework of Article 43 of Regulation (EC) No 396/2005 for the preparation of the EU position for 57th Session of the Codex Committee on Pesticide Residues (CCPR). In the current report, EFSA provided comments and recommendations on the proposed Codex maximum residue limits (CXLs ...
European Food Safety Authority (EFSA)
wiley   +1 more source

Synthesis and evaluation of the antimicrobial activity of novel esters, β-diketones, chromones and pyrazoles. [PDF]

RSC Adv
Shinde AS, Badadhe SP, Kunde SP, Gaikwad DN, Pawar BS, Badadhe PV.   +5 more
europepmc   +1 more source

Lucigenin: a strongly oxidizing dicationic photocatalyst for the direct azolation of arenes. [PDF]

Chem Sci
Matei A, Roure B, Chen X, Beil SB, Feringa BL.   +4 more
europepmc   +1 more source