Results 181 to 190 of about 37,807 (249)

Silver-Mediated [3 + 2] Cycloaddition of Alkynes and N-Isocyanoiminotriphenylphosphorane: Access to Monosubstituted Pyrazoles.

Organic Letters, 2019
A silver-mediated [3 + 2] cycloaddition of "CNN" and "C≡C" for constructing pyrazoles has been described. The "CNN" building block used is N-isocyanoiminotriphenylphosphorane, which is a stable, safe, easy-to-handle, and odorless solid isocyanide.
Fanhua Yi, Wanjun Zhao, Zikun Wang, X. Bi   +3 more
semanticscholar   +1 more source

Pyrazole: preclinical reassessment

Investigational New Drugs, 1988
Pyrazole (NSC-45410) is a low molecular weight, heterocyclic compound which has been considered for reevaluation in the clinic as a potential cytotoxic agent (Fig. 1). Discovered in 1893, pyrazole is best known as an inhibitor of liver alcohol dehydrogenase (ki = 0.2 uM), and as a result, has been used extensively in studies of alcohol metabolism.
P J, O'Dwyer, S A, King, J, Plowman, C K, Grieshaber, D F, Hoth, B, Leyland-Jones   +5 more
openaire   +2 more sources

Synthesis and antibacterial evaluation of fused pyrazoles and Schiff bases

Synthetic Communications, 2018
For the discovery of new antibiotic drugs to face the problem of microbial resistance, a series of fused pyrazoles such as pyrazolopyrimidines 15a–f, pyrazoloquinazolines 18a, b and pyrazolotriazines 20a, b was synthesized via the reaction of 5 ...
Ashraf S. Hassan, G. Moustafa, A. Askar, A. Naglah, M. Al-Omar   +4 more
semanticscholar   +1 more source

Preparation of Pyrazole–Pyrazolate Half‐Sandwich Complexes of Ruthenium and Osmium

European Journal of Inorganic Chemistry, 2010
AbstractPyrazole (HRpz) [MCl(η6‐p‐cymene)(HRpz)L]BPh4 (1–8) and imidazole (HIm) complexes [MCl(η6‐p‐cymene)(HIm)L]BPh4 (9–10) [M = Ru, Os; R = H, 3‐Me, 3,5‐Me2; L = P(OEt)3, PPh(OEt)2, PPh2OEt, CNtBu] were prepared by allowing the dichloro compounds MCl2(η6‐p‐cymene)L to react with the appropriate azole in the presence of NaBPh4.
ALBERTIN, Gabriele, ANTONIUTTI, Stefano, J. Castro, S. García Fontán   +3 more
openaire   +1 more source

Diastereoselective synthesis and cytotoxic evaluation of new isoxazoles and pyrazoles with monoterpenic skeleton

, 2019
New series of chiral isoxazoles and pyrazoles with monoterpenic skeleton, have been efficiently synthesized from naturally occurring (R)-Carvone, using 1,3-dipolar cycloaddition reaction with arylonitrile oxides and diarylnitrilimines.
Ali Oubella, M. Y. A. Itto, A. Auhmani, A. Riahi, A. Robert, J. Daran, H. Morjani, C. Parish, M. Esseffar   +8 more
semanticscholar   +1 more source

Pyrazole Complexes as Anion Receptors:  Effects of Changing the Metal, the Pyrazole Substitution Pattern, and the Number of Pyrazole Ligands

Inorganic Chemistry, 2007
Compound cis,fac-[Mo(eta3-allyl)(CO)2(Hdmpz)3]BAr'4 (1) (Hdmpz = 3,5-dimethylpyrazole, Ar' = 3,5-bis(trifluoromethyl)phenyl) undergoes rapid substitution of one of the pyrazole ligands by anions, including the low nucleophilic ReO4-, a reaction that afforded [Mo(OReO3)(eta3-allyl)(CO)2(Hdmpz)2] (2), structurally characterized by X-ray diffraction.
Sonia, Nieto, Julio, Pérez, Lucía, Riera, Víctor, Riera, Daniel, Miguel, James A, Golen, Arnold L, Rheingold   +6 more
openaire   +2 more sources

Pyrazole, 3(5)-methyl pyrazole and 3,5-dimethyl pyrazole complexes of tin(IV) halides

Inorganica Chimica Acta, 1977
Abstract Complexes of tin(IV) halides with pyrazole, 3(5)methyl pyrazole and 3,5-dimethyl pyrazole of the type SnX4·L2 were prepared. All the isolated solids were non-electrolytes in acetonitrile. The IR spectra of the complexes (600–180 cm−1 were consistent with a trans-octahedral configuration in the solids state.
J.R. Masaguer, E. Freijanes, J. Sordo, J.S. Casas, M.R. Bermejo   +4 more
openaire   +1 more source

Microwave spectra of isotopic pyrazoles and molecular structure of pyrazole

Journal of Molecular Structure, 1974
Abstract Microwave spectra of the complete set of monosubstituted isotopic pyrazoles have been investigated and the complete r s structure of pyrazole determined. The deuterated and 15 N species of pyrazole were prepared, while the 13 C species were examined in natural abundance.
Lise Nygaard, Dines Christen, J.Tormod Nielsen, E.Jonas Pedersen, Ole Snerling, Erik Vestergaard, G.Ole Sørensen   +6 more
openaire   +1 more source

Octahedral molybdenum iodide clusters with pyrazole or pyrazolate ligands

Dalton Transactions
Hexaaqua or hexahydroxo molybdenum iodide cluster complexes obtained in one step were shown to be accessible complexes for synthesis of clusters with pyrazole or pyrazolate ligands.
Ksenia S. Kozlova, Alexey S. Berezin, Natalia V. Kuratieva, Michael A. Shestopalov, Anton A. Ivanov   +4 more
openaire   +2 more sources

Synthesis and Antimycobacterial Evaluation of Novel Pyrazole‐Isoxazolines and Pyrazole‐Isoxazoles

ChemBioChem
AbstractThis study reports the synthesis of a new series of pyrazole‐isoxazolines, at very good yields, from the cyclocondensation reaction of pyrazole‐enaminones with hydroxylamine hydrochloride. Dehydration of the pyrazole‐isoxazolines furnished another new series of the respective pyrazole‐isoxazoles, at excellent yields. Both series of the obtained
Paulo A. Moraes, Thaise Dill Fussinger, Tuyla Fontana, Genilson S. Pereira, Mário A. Marangoni, Adriano F. Camargo, Helio G. Bonacorso, Marcos A. P. Martins, Alencar K. Machado, Marli M. A. de Campos, Nilo Zanatta   +10 more
openaire   +2 more sources