Results 171 to 180 of about 2,698 (209)

Development of 1,2,3-Triazolopyridazinone Derivatives as Potential Caspase 3 and Apoptosis Inducers: Design, Synthesis and Anticancer Activity Studies. [PDF]

J Biochem Mol Toxicol
Erdemir GY, Kuruçay A, Ates B, Altundas A.   +3 more
europepmc   +1 more source

Synthesis, crystal structures and biological evaluation of new pyridazine derivatives

Journal of Molecular Structure, 2020
A series of functionalized pyridazine derivatives (1–10) 4-phenyl-3,6-di(pyridine-4-yl)pyridazine (1), 3-(3,6-di(pyridin-4-yl)pyridazin-4-yl)aniline (2), 4-(pyridin-3-yl)-3,6-di(pyridin-4-yl)pyridazine (3), 3,6-di(pyridin-4-yl)-4-(thiophen-2-yl ...
Balaram Pani, Deepak Gupta
exaly   +2 more sources

Immobilization of Fe(III) complexes of pyridazine derivatives prepared from biosorbents supported on zeolites [PDF]

Microporous and Mesoporous Materials, 2008
Immobilization of Fe(III) complexes of pyridazine derivatives was achieved in NaY zeolite, loaded with iron through the action of a robust biosorption mediator consisting of a bacterial biofilm, Arthrobacter viscosus, supported on the zeolite.
Hugo Figueiredo, Bruna Silva, M Manuela M Raposo   +2 more
exaly   +2 more sources

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Iptycene-Derived Pyridazines and Phthalazines

The Journal of Organic Chemistry, 2007
The synthesis of new heterocyclic oligo(phenylene) analogues based on soluble, nonaggregating 1,2-diazines is reported. Improved palladium-catalyzed reductive coupling methods were developed to allow for the preparation of large quantities of iptycene-derived bipyridazines and biphthalazines, and the controlled synthesis of well-defined oligomers up to
Jean, Bouffard, Robert F, Eaton, Peter, Müller, Timothy M, Swager   +3 more
openaire   +2 more sources

Synthesis of new annulated pyridazine derivatives and studying their antioxidant and antimicrobial activities

Synthetic Communications, 2019
Benzil was reacted with cyanoacetohydrazide under microwave irradiation to give 3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carbonitrile 1 which used as starting material for the synthesis of new heterocyclic compounds. Chlorination of pyridazinone 1 with
Heba E Hashem, David S A Haneen, Khaled F Saïed   +2 more
exaly   +2 more sources

Pyridazine-derived γ-secretase modulators

Bioorganic & Medicinal Chemistry Letters, 2011
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.
Zehong, Wan, Adrian, Hall, Yun, Jin, Jia-Ning, Xiang, Eric, Yang, Andrew, Eatherton, Beverley, Smith, Guang, Yang, Haihua, Yu, Ju, Wang, Liang, Ye, Lit-Fui, Lau, Ting, Yang, William, Mitchell, Wei, Cai, Xiaomin, Zhang, Yingxia, Sang, Yonghui, Wang, Zhaolong, Tong, Ziqiang, Cheng, Ishrut, Hussain, John D, Elliott, Yasuji, Matsuoka   +22 more
openaire   +2 more sources

Synthesis of α‐(Trifluoromethyl)pyridazine Derivatives

European Journal of Organic Chemistry, 2018
Over the last decades, an increasing interest in α‐(trifluoromethyl)pyridazines in medicinal chemistry has been noticed. This interest stems firstly from the recent development of biologically active pyridazines as well as from the capacity of the pyridazine ring to be a bioisoster of other heterocycles.
Feraldi-Xypolia, Alexandra, Gomez Pardo, Domingo, Cossy, Janine   +2 more
openaire   +2 more sources

Pyridazine Derivatives, VII. Synthesis and Hypotensive Activity of 3‐Hydrazinocycloalkyl[1,2‐c]pyridazines and their Derivatives

Archiv der Pharmazie, 1989
AbstractThe preparation of a series of 3‐hydrazinocycloalkyl[1,2‐c]‐pyridazines 7 and some derivatives as hydrazones 8, 9, triazoles 10 and pyrroles 11 are described together with their hypotensive activity in normotensive rats.
C, Terán, E, Raviña, L, Santana, N, García-Domínguez, G, García-Mera, J A, Fontenla, F, Orallo, J M, Calleja   +7 more
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Neue Derivate des Pyridazins

Journal für Praktische Chemie, 1969
AbstractDas neuerdings leicht zugängliche 3‐Amino‐4‐hydroxy‐6‐methy1‐pyridazin 1 [1] erschließt einen neuen Zugang zu Derivaten des Pyridazins. Die Umsetzung mit salpetriger Säure liefert in verdünnter Schwefelsäure 3,4‐Dihydroxy‐6‐methyl‐pyridazin 3, in konz. Salzsäure dagegen 3‐Chlor‐4‐hydroxy‐6‐methylpyridazin 2.
H. G. O. Becker, H. Böttcher, J. Koch
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Silyl‐Derivate von Pyridazin

Chemische Berichte, 1981
AbstractDie Umsetzung von 1,2,4,5‐Tetrazin‐3,6‐dicarbonsäure‐dimethylester (1) mit den Silylalkinen 2a ‐ f führt über die nicht isolierbaren Diels‐Alder‐Addukte zu den 4‐Alkyl‐5‐(trimethylsilyl)‐3,6‐pyridazindicarbonsäure dimethylestern 3a ‐ f. Im Fall des 1,4‐Bis(trimethylsilyl)‐1,3‐butadiins (2g) reagiert nur eine Dreifachbindung mit 1 unter Bildung ...
Leonhard Birkofer, Edward Hänsel
openaire   +1 more source