Results 181 to 190 of about 5,173 (205)

Pyridazine-derived γ-secretase modulators

Bioorganic & Medicinal Chemistry Letters, 2011
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.
Zehong, Wan, Adrian, Hall, Yun, Jin, Jia-Ning, Xiang, Eric, Yang, Andrew, Eatherton, Beverley, Smith, Guang, Yang, Haihua, Yu, Ju, Wang, Liang, Ye, Lit-Fui, Lau, Ting, Yang, William, Mitchell, Wei, Cai, Xiaomin, Zhang, Yingxia, Sang, Yonghui, Wang, Zhaolong, Tong, Ziqiang, Cheng, Ishrut, Hussain, John D, Elliott, Yasuji, Matsuoka   +22 more
openaire   +2 more sources

Iptycene-Derived Pyridazines and Phthalazines

The Journal of Organic Chemistry, 2007
The synthesis of new heterocyclic oligo(phenylene) analogues based on soluble, nonaggregating 1,2-diazines is reported. Improved palladium-catalyzed reductive coupling methods were developed to allow for the preparation of large quantities of iptycene-derived bipyridazines and biphthalazines, and the controlled synthesis of well-defined oligomers up to
Jean, Bouffard, Robert F, Eaton, Peter, Müller, Timothy M, Swager   +3 more
openaire   +2 more sources

Silyl‐Derivate von Pyridazin

Chemische Berichte, 1981
AbstractDie Umsetzung von 1,2,4,5‐Tetrazin‐3,6‐dicarbonsäure‐dimethylester (1) mit den Silylalkinen 2a ‐ f führt über die nicht isolierbaren Diels‐Alder‐Addukte zu den 4‐Alkyl‐5‐(trimethylsilyl)‐3,6‐pyridazindicarbonsäure dimethylestern 3a ‐ f. Im Fall des 1,4‐Bis(trimethylsilyl)‐1,3‐butadiins (2g) reagiert nur eine Dreifachbindung mit 1 unter Bildung ...
Leonhard Birkofer, Edward Hänsel
openaire   +1 more source

Neue Derivate des Pyridazins

Journal für Praktische Chemie, 1969
AbstractDas neuerdings leicht zugängliche 3‐Amino‐4‐hydroxy‐6‐methy1‐pyridazin 1 [1] erschließt einen neuen Zugang zu Derivaten des Pyridazins. Die Umsetzung mit salpetriger Säure liefert in verdünnter Schwefelsäure 3,4‐Dihydroxy‐6‐methyl‐pyridazin 3, in konz. Salzsäure dagegen 3‐Chlor‐4‐hydroxy‐6‐methylpyridazin 2.
H. G. O. Becker, H. Böttcher, J. Koch
openaire   +1 more source

Synthesis of α‐(Trifluoromethyl)pyridazine Derivatives

European Journal of Organic Chemistry, 2018
Over the last decades, an increasing interest in α‐(trifluoromethyl)pyridazines in medicinal chemistry has been noticed. This interest stems firstly from the recent development of biologically active pyridazines as well as from the capacity of the pyridazine ring to be a bioisoster of other heterocycles.
Feraldi-Xypolia, Alexandra, Gomez Pardo, Domingo, Cossy, Janine   +2 more
openaire   +2 more sources

Acid-Induced Multicolor Fluorescence of Pyridazine Derivative

ACS Applied Materials & Interfaces, 2017
Smart luminescent materials that are responsive to external stimuli have received considerable attention. Here, we report a new D-A type 1,2-pyridiazine derivative (3,4,5,6-tetrakis(4-methoxyphenyl)pyridazine (TPP)) exhibiting turn-on fluorescence upon acid exposure both in solution and in the solid state.
Mengwei Li, Yuan Yuan, Yulan Chen
openaire   +2 more sources

Synthesis of pyrazolo [4,5]pyridazine and isoxazolo [3,4d]pyridazine derivatives

Archives of Pharmacal Research, 1992
Arylhydrazones of diethylacetondicarboxylate3 was treated with formaldehyde to give 1-aryl-4,5,6-trihydropyridaine derivatives4a-f Cyclization of compound4a-f by hydroxylamine afforded [3,4d] 1,3,4,5-tetrahydropyridazine derivatives5a-f. Also cyclization of compound4c with semicarbazide gave 1-amidopyrazolo-5-one-1-aryl-3-carboxypyridazine6.
Ikhlass M. Abbass, Mohyee A. F. Sharaf, Alia A. El-damaty   +2 more
openaire   +1 more source

Pyridazine Derivatives, VII. Synthesis and Hypotensive Activity of 3‐Hydrazinocycloalkyl[1,2‐c]pyridazines and their Derivatives

Archiv der Pharmazie, 1989
AbstractThe preparation of a series of 3‐hydrazinocycloalkyl[1,2‐c]‐pyridazines 7 and some derivatives as hydrazones 8, 9, triazoles 10 and pyrroles 11 are described together with their hypotensive activity in normotensive rats.
C, Terán, E, Raviña, L, Santana, N, García-Domínguez, G, García-Mera, J A, Fontenla, F, Orallo, J M, Calleja   +7 more
openaire   +2 more sources

Herbicidal Activity of Some Pyridazine Derivatives

Agricultural and Biological Chemistry, 1963
Herbicidal activity of some 50 pyridazyl ethers was evaluated. Among them, 3-chloro-6-(2-phenylphenoxy)-, 3-chloro-6-(2,6-dichlorophenoxy)-, 3-chloro-6-(3-methoxyphenoxy)- and 3-chloro-6-(4-methoxyphenoxy)-pyridazines showed conspicuous effectiveness on radish and millet in pre-emergence test, whereas postemergent activity of the compounds tested was ...
Saburo Tamura, Teruomi Jojima
openaire   +1 more source

Synthesis of pyridazine derivatives—XXVIII

Tetrahedron, 1967
B. Stanovnik, M. Tišler
openaire   +1 more source