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Pyridazines. XXIII. A novel pyridazine into pyrazole ring transformation
Journal of Heterocyclic Chemistry, 1984AbstractTreatment of phenyl(4‐pyridazinyl)methanols 1a and 1b with p‐toluenesulfonic acid at elevated temperatures causes transformation into the C‐4 substituted pyrazole derivatives 8a and 8b. Limitations of this novel rearrangement reaction as well as mechanistic considerations are discussed.
Gottfried Heinisch, Richard Waglechner
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[Biotransformation of pyridazines. 1. Pyridazine and 3-methylpyridazine].
Die Pharmazie, 1990Pyridazin (1) and 3-methylpyridazine (6) undergo oxidative biotransformation in an unexpected high degree. Beside the unchanged compounds, after administration of 1 two isomeric monohydroxylated products (2, 3), 4,5-dihydrodihydroxypyridazine (4) and 4,5-dihydroxypyridazine (5) and after administration of 6 one ringhydroxylated 6-derivative (7), 3 ...
H H, Borchert +4 more
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Pyridazines. LXXXIV. Studies on borohydride reduction of pyridazine compounds
Journal of Heterocyclic Chemistry, 1976AbstractImidazo[1,2‐b]pyridazine, s‐triazolo[4,3‐b]pyridazine and tetrazolo[1,5‐b]pyridazine and some derivatives thereof were reduced with sodium borohydride to give the corresponding 5,6,7,8‐tetrahydro derivatives. A mechanism for these reductions is proposed and reduction at the C7‐C8 bond occurs before the reduction of the C6N5 bond.
P. K. Kadaba, B. Stanovnik, M. Tišler
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Pyridazines. XXXVII. Pyrimido[1,2-b]pyridazines
The Journal of Organic Chemistry, 1971Miha Tisler +2 more
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Ag-catalyzed decarboxylative acylation of pyridazines using α-keto acids in aqueous media
Tetrahedron Letters, 2021Qijie Xu, Dapeng Zou, Shengqiang Wang
exaly
Synthetic Pathways to Pyrido[3,4-c]pyridazines and Their Polycyclic Derivatives
Organics, 2022Flavio S Emery +2 more
exaly